Laboratory of Structural Biology

Organisational unit: Research Group

Organisation Profile

Our research in the Laboratory of Structural Biology (LSB) at the Helsinki Institute of Life Science (HiLIFE) is aimed at understanding the structure and function of biological macromolecules and their complexes, such as molecular machines and viruses. We strive to decipher possible common principles in their assembly and evolution. Detailed mechanistic understanding of structures involved in disease is informing rational design of therapies. 

We apply a broad range of molecular biology and bio-imaging methods in our research. Our core skills centre around cryogenic transmission electron microscopy (cryo-EM), a method suitable for structural studies of small proteins, large complexes, viruses, and even organelles or sections of cells. We are active in computational method development for processing data from such targets.

Our research is funded by the European Research Council under the European Union’s Horizon 2020 research and innovation programme (PI's ERC Consolidator grant) and HiLIFE.

 

Latest research outputs

  1. Accepted/In press

    Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus

    Research output: Contribution to journalArticleScientificpeer-review

  2. The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins

    Research output: Contribution to journalArticleScientificpeer-review

  3. Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils

    Research output: Contribution to journalArticleScientificpeer-review

ID: 89924114