Macromolecular structure and function

Organisational unit: Research Group

Organisation Profile

Our work aims to understand the structure, assembly and function of biological macromolecule complexes. We embed unstained, unfixed specimens in vitreous ice to preserve their structures. Transmission cryo-electron microscopy is then used to visualize the specimens, but the images recorded are difficult to interpret because they are projections of the specimen degraded by noise. Thus we computationally combine images of the specimen viewed from different angles enabling us to reconstruct a three-dimensional model. Any inherent symmetry present in the structure is also used in this averaging. This method is particularly useful for objects that are too large, unstable or variable to be studied by X-ray crystallography or NMR, such as enveloped viruses.

Latest research outputs

  1. Progress in human picornavirus research: New findings from the AIROPico consortium

    Research output: Contribution to journalArticleScientificpeer-review

  2. Tick-Borne Encephalitis Virus: A Structural View

    Research output: Contribution to journalReview ArticleScientificpeer-review

ID: 2615039