Institute for Molecular Medicine Finland (FIMM)

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  1. Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

    Day, F. R., Thompson, D. J., Helgason, H., Chasman, D. I., Finucane, H., Sulem, P., Ruth, K. S., Whalen, S., Sarkar, A. K., Albrecht, E., Altmaier, E., Amini, M., Barbieri, C. M., Boutin, T., Campbell, A., Demerath, E., Giri, A., He, C., Hottenga, J. J., Karlsson, R., Kolcic, I., Loh, P-R., Lunetta, K. L., Mangino, M., Marco, B., McMahon, G., Medland, S. E., Nolte, I. M., Noordam, R., Nutile, T., Paternoster, L., Perjakova, N., Porcu, E., Rose, L. M., Schraut, K. E., Segre, A. V., Smith, A. V., Stolk, L., Teumer, A., Andrulis, I. L., Bandinelli, S., Beckmann, M. W., Benitez, J., Bergmann, S., Bochud, M., Boerwinkle, E., Bojesen, S. E., Bolla, M. K., Brand, J. S., Brauch, H., Brenner, H., Broer, L., Bruning, T., Buring, J. E., Campbell, H., Catamo, E., Chanock, S., Chenevix-Trench, G., Corre, T., Couch, F. J., Cousminer, D. L., Cox, A., Crisponi, L., Czene, K., Smith, G. D., de Geus, E. J. C. N., de Mutsert, R., De Vivo, I., Dennis, J., Devilee, P., dos-Santos-Silva, I., Dunning, A. M., Eriksson, J. G., Fasching, P. A., Fernandez-Rhodes, L., Ferrucci, L., Flesch-Janys, D., Franke, L., Gabrielson, M., Gandin, I., Giles, G. G., Grallert, H., Gudbjartsson, D. F., Guenel, P., Hall, P., Hallberg, E., Hamann, U., Harris, T. B., Hartman, C. A., Heiss, G., Hooning, M. J., Hopper, J. L., Hu, F., Hunter, D. J., Ikram, M. A., Im, H. K., Jarvelin, M-R., Joshi, P. K., Karasik, D., Kellis, M., Kutalik, Z., LaChance, G., Lambrechts, D., Langenberg, C., Launer, L. J., Laven, J. S. E., Lenarduzzi, S., Li, J., Lind, P. A., Lindstrom, S., Liu, Y., Luan, J., Magi, R., Mannermaa, A., Mbarek, H., McCarthy, M. I., Meisinger, C., Meitinger, T., Menni, C., Metspalu, A., Michailidou, K., Milani, L., Milne, R. L., Montgomery, G. W., Mulligan, A. M., Nalls, M. A., Navarro, P., Nevanlinna, H., Nyholt, D. R., Oldehinkel, A. J., O'Mara, T. A., Padmanabhan, S., Palotie, A., Pedersen, N., Peters, A., Peto, J., Pharoah, P. D. P., Pouta, A., Radice, P., Rahman, I., Ring, S. M., Robino, A., Rosendaal, F. R., Rudan, I., Rueedi, R., Ruggiero, D., Sala, C. F., Schmidt, M. K., Scott, R. A., Shah, M., Sorice, R., Southey, M. C., Sovio, U., Stampfer, M., Steri, M., Strauch, K., Tanaka, T., Tikkanen, E., Timpson, N. J., Traglia, M., Truong, T., Tyrer, J. P., Uitterlinden, A. G., Edwards, D. R. V., Vitart, V., Voelker, U., Vollenweider, P., Wang, Q., Widen, E., van Dijk, K. W., Willemsen, G., Winqvist, R., Wolffenbuttel, B. H. R., Zhao, J. H., Zoledziewska, M., Zygmunt, M., Alizadeh, B. Z., Boomsma, D. I., Ciullo, M., Cucca, F., Esko, T., Franceschini, N., Gieger, C., Gudnason, V., Hayward, C., Kraft, P., Lawlor, D. A., Magnusson, P. K. E., Martin, N. G., Mook-Kanamori, D. O., Nohr, E. A., Polasek, O., Porteous, D., Price, A. L., Ridker, P. M., Snieder, H., Spector, T. D., Stoeckl, D., Toniolo, D., Ulivi, S., Visser, J. A., Voelzke, H., Wareham, N. J., Wilson, J. F., Spurdle, A. B., Thorsteindottir, U., Pollard, K. S., Easton, D. F., Tung, J. Y., Chang-Claude, J., Hinds, D., Murray, A., Murabito, J. M., Stefansson, K., Ong, K. K., Perry, J. R. B., LifeLines Cohort Study, InterAct Consortium, kConFab AOCS Investigators, Endometrial Canc Accoc Consortium, Ovarian Canc Accoc Consortium & PRACTICAl Consortium Jun 2017 In : Nature Genetics. 49, 6, p. 834-+ 11 p.

    Publication: Contribution to journalA1 Refereed journal article

  2. Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

    Saleheen, D., Zhao, W., Young, R., Nelson, C. P., Ho, W., Ferguson, J. F., Rasheed, A., Ou, K., Nurnberg, S. T., Bauer, R. C., Goel, A., Do, R., Stewart, A. F. R., Hartiala, J., Zhang, W., Thorleifsson, G., Strawbridge, R. J., Sinisalo, J., Kanoni, S., Sedaghat, S., Marouli, E., Kristiansson, K., Zhao, J. H., Scott, R., Gauguier, D., Shah, S. H., Smith, A. V., van Zuydam, N., Cox, A. J., Willenborg, C., Kessler, T., Zeng, L., Province, M. A., Ganna, A., Lind, L., Pedersen, N. L., White, C. C., Joensuu, A., Kleber, M. E., Hall, A. S., Maerz, W., Salomaa, V., O'Donnell, C., Ingelsson, E., Feitosa, M. F., Erdmann, J., Bowden, D. W., Palmer, C. N. A., Gudnason, V., De Faire, U., Zalloua, P., Wareham, N., Thompson, J. R., Kuulasmaa, K., Dedoussis, G., Perola, M., Dehghan, A., Chambers, J. C., Kooner, J., Allayee, H., Deloukas, P., McPherson, R., Stefansson, K., Schunkert, H., Kathiresan, S., Farrall, M., Frossard, P. M., Rader, D. J., Samani, N. J., Reilly, M. P., PROMIS & Cardiogramplusc4D 13 Jun 2017 In : Circulation . 135, 24, p. 2336-+ 45 p.

    Publication: Contribution to journalA1 Refereed journal article

  3. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

    Tachmazidou, I., Suveges, D., Min, J. L., Ritchie, G. R. S., Steinberg, J., Walter, K., Iotchkova, V., Schwartzentruber, J., Huang, J., Memari, Y., McCarthy, S., Crawford, A. A., Bombieri, C., Cocca, M., Farmaki, A-E., Gaunt, T. R., Jousilahti, P., Kooijman, M. N., Lehne, B., Malerba, G., Mannisto, S., Matchan, A., Medina-Gomez, C., Metrustry, S. J., Nag, A., Ntalla, I., Paternoster, L., Rayner, N. W., Sala, C., Scott, W. R., Shihab, H. A., Southam, L., St Pourcain, B., Traglia, M., Trajanoska, K., Zaza, G., Zhang, W., Artigas, M. S., Bansal, N., Benn, M., Chen, Z., Danecek, P., Lin, W-Y., Locke, A., Luan, J., Manning, A. K., Mulas, A., Sidore, C., Tybjaerg-Hansen, A., Varbo, A., Zoledziewska, M., Finan, C., Hatzikotoulas, K., Hendricks, A. E., Kemp, J. P., Moayyeri, A., Panoutsopoulou, K., Szpak, M., Wilson, S. G., Boehnke, M., Cucca, F., Di Angelantonio, E., Langenberg, C., Lindgren, C., McCarthy, M. I., Morris, A. P., Nordestgaard, B. G., Scott, R. A., Tobin, M. D., Wareham, N. J., Burton, P., Chambers, J. C., Smith, G. D., Dedoussis, G., Felix, J. F., Franco, O. H., Gambaro, G., Gasparini, P., Hammond, C. J., Hofman, A., Jaddoe, V. W. V., Kleber, M., Kooner, J. S., Perola, M., Relton, C., Ring, S. M., Rivadeneira, F., Salomaa, V., Spector, T. D., Stegle, O., Toniolo, D., Uitterlinden, A. G., Barroso, I., Greenwood, C. M. T., Perry, J. R. B., Walker, B. R., Butterworth, A. S., Xue, Y., Durbin, R., Small, K. S., Soranzo, N., Timpson, N. J., Zeggini, E., SpiroMeta Consortium, GoT2D Consortium, ArcOGEN Consortium, Understanding Soc Sci Grp & UK10KConsortium 1 Jun 2017 In : American Journal of Human Genetics. 100, 6, p. 865-884 20 p.

    Publication: Contribution to journalA1 Refereed journal article

  4. Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

    Luukkonen, P. K., Zhou, Y., Haridas, N. P. A., Dwivedi, O. P., Hyotylainen, T., Ali, A., Juuti, A., Leivonen, M., Tukiainen, T., Ahonen, L., Scott, E., Palmer, J. M., Arola, J., Orho-Melander, M., Vikman, P., Anstee, Q. M., Olkkonen, V. M., Oresic, M., Groop, L. & Yki-Jarvinen, H. Jul 2017 In : Journal of Hepatology. 67, 1, p. 128-136 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  5. Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

    Bogl, L. H., Jelenkovic, A., Vuoksimaa, E., Ahrenfeldt, L., Pietilainen, K. H., Stazi, M. A., Fagnani, C., D'Ippolito, C., Hur, Y-M., Jeong, H-U., Silberg, J. L., Eaves, L. J., Maes, H. H., Bayasgalan, G., Narandalai, D., Cutler, T. L., Kandler, C., Jang, K. L., Christensen, K., Skytthe, A., Kyvik, K. O., Cozen, W., Hwang, A. E., Mack, T. M., Derom, C. A., Vlietinck, R. F., Nelson, T. L., Whitfield, K. E., Corley, R. P., Huibregtse, B. M., McAdams, T. A., Eley, T. C., Gregory, A. M., Krueger, R. F., Mcgue, M., Pahlen, S., Willemsen, G., Bartels, M., van Beijsterveldt, T. C. E. M., Pang, Z., Tan, Q., Zhang, D., Martin, N. G., Medland, S. E., Montgomery, G. W., Hjelmborg, J. V. B., Rebato, E., Swan, G. E., Krasnow, R., Busjahn, A., Lichtenstein, P., Oncel, S. Y., Aliev, F., Baker, L. A., Tuvblad, C., Siribaddana, S. H., Hotopf, M., Sumathipala, A., Rijsdijk, F., Magnusson, P. K. E., Pedersen, N. L., Aslan, A. K. D., Ordonana, J. R., Sanchez-Romera, J. F., Colodro-Conde, L., Duncan, G. E., Buchwald, D., Tarnoki, A. D., Tarnoki, D. L., Yokoyama, Y., Hopper, J. L., Loos, R. J. F., Boomsma, D. I., Sorensen, T. I. A., Silventoinen, K. & Kaprio, J. 27 Apr 2017 In : Biology of sex differences. 8, 12 p., 14

    Publication: Contribution to journalA1 Refereed journal article

  6. Pilot Study on the Genetic Background of an Active Matrix Metalloproteinase-8 Test in Finnish Adolescents

    Heikkinen, A. M., Raivisto, T., Kettunen, K., Kovanen, L., Haukka, J., Pakbaznejad Esmaeili, E., Elg, J., Gieselmann, D-R., Rathnayake, N., Ruokonen, H., Tervahartiala, T. & Sorsa, T. May 2017 In : Journal of Periodontology. 88, 5, p. 464-472 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  7. Novel Assay to Detect RNA Polymerase I Activity In Vivo

    Guner, G., Sirajuddin, P., Zheng, Q., Bai, B., Brodie, A., Liu, H., af Hallstrom, T., Kulac, I., Laiho, M. & De Marzo, A. M. May 2017 In : Molecular Cancer Research. 15, 5, p. 577-584 8 p.

    Publication: Contribution to journalA1 Refereed journal article

  8. High-Throughput Dual Screening Method for Ras Activities and Inhibitors

    Kopra, K., van Adrichem, A. J., Salo-Ahen, O. M. H., Peltonen, J., Wennerberg, K. & Harma, H. 18 Apr 2017 In : Analytical Chemistry. 89, 8, p. 4508-4516 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  9. Enhanced sensitivity to glucocorticoids in cytarabine-resistant AML

    Malani, D., Murumagi, A., Yadav, B., Kontro, M., Eldfors, S., Kumar, A., Karjalainen, R., Majumder, M. M., Ojamies, P., Pemovska, T., Wennerberg, K., Heckman, C., Porkka, K., Wolf, M., Aittokallio, T. & Kallioniemi, O. May 2017 In : Leukemia. 31, 5, p. 1187-1195 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  10. Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

    Rodriguez-Broadbent, H., Law, P. J., Sud, A., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Ripatti, S., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Palotie, A., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Passarelli, M. N., Figueiredo, J. C., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Aaltonen, L. A., Cheadle, J. P., Tomlinson, I. P., Dunlop, M. G. & Houlston, R. S. 15 Jun 2017 In : International Journal of Cancer. 140, 12, p. 2701-2708 8 p.

    Publication: Contribution to journalA1 Refereed journal article

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