Jari Yli-Kauhaluoma

Person

Education information

Research interests

Medicinal chemistry of

  • combating bacterial biofilms and Gram-negative bacteria with novel antimicrobial compounds
  • chemical induction of cellular reprogramming and differentiation
  • targeting intracellular protozoan parasites (Leishmania sp., Plasmodium falciparum)
  • bioactive terpenes of marine and forest sources
  • novel synthesis methods of bioactive compounds

Topics of recent publications 

  • Design, synthesis and biological activity of compounds targeted to Pim and the C1 domain of PKC
  • Terpene-derived compounds as antileishmanial agents
  • Design, synthesis and biological activity of heterocycles and terpenoids against pathogenic parasites and Gram-negative bacteria
  • Benzo[cd]azulenes: synthesis of azulene, heptafulvene, and tropone derivatives and activity against Pim kinases

Teaching activities

  • Person-in-Charge of the organic chemistry in life sciences curriculum in the Viikki Campus

Recent administrative duties

  • Vice Dean for Research, Faculty of Pharmacy, 2018-
  • Head of the Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, 2014-2017
  • President of the Finnish Chemical Society, 2016-2018
  • Co-ordinator of the Marie Curie project PRINT-AID, 2017-
  • Vice Co-ordinator of the EC-FP7 projects MAREX, 2010-14 & GLORIA, 2013-18
  • Member of the CBRN Division of the Scientific Advisory Board for Defence, 2006-
  • Member of the Pharmacopoeia Committee of the Finnish Medicines Agency, 2010-
  • Member of the Expert Panel: FWO Research Foundation - Flanders, Belgium, 2012-2015
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Further information on the affiliationProfessor of Medicinal Chemistry

Curriculum Vitae

Highlighted publications

  1. New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

    Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero, A. & Moreira, V. M., 21 Jul 2015, In : European Journal of Medicinal Chemistry. 102, p. 68-79 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

  2. A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

    Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F. & Yli-Kauhaluoma, J., 11 Jun 2015, In : Journal of Medicinal Chemistry. 58, 11, p. 4573-4580 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  3. Pyrofosfaatti lääketieteessä

    Goldman, A., Boije af Gennäs, P. G., Xhaard, H. G. M., Meri, S. K. & Yli-Kauhaluoma, J. T., 2016, In : Duodecim. 132, 12, p. 1111-1117 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  4. Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo

    Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., Feb 2016, In : Journal of Natural Products. 79, 2, p. 274-280 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  5. Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

    Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., Feb 2016, In : Journal of Natural Products. 79, 2, p. 362-368 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  6. Design and Synthesis of 2-Arylbenzimidazoles and Evaluation of Their Inhibitory Effect against Chlamydia pneumoniae.

    Keurulainen, L., Salin, O., Siiskonen, A., Kern, J. M., Alvesalo, J. K. O., Kiuru, P., Maass, M., Yli-Kauhaluoma, J. & Vuorela, P., 2010, In : Journal of Medicinal Chemistry. 53, 21, p. 7664-7674 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  7. The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

    Talman, V., Amadio, M., Osera, C., Sorvari, S., Boije af Gennäs, G., Yli-Kauhaluoma, J., Rossi, D., Govoni, S., Collina, S., Ekokoski, E., Tuominen, R. K. & Pascale, A., 2013, In : Pharmacological Research. 73, p. 44-54 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  8. Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed Cells

    Kiriazis, A., Vahakoski, R. L., Santio, N. M., Arnaudova, R., Eerola, S. K., Rainio, E-M., Aumuller, I. B., Yli-Kauhaluoma, J. & Koskinen, P. J., 2013, In : PLoS One. 8, 2, p. e55409 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  9. Albumin Stimulates the Activity of the Human UDP-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects are Enzyme and Substrate Dependent

    Manevski, N., Troberg, J., Svaluto-Moreolo, P., Dziedzic, K., Yli-Kauhaluoma, J. & Finel, M., 2013, In : PLoS One. 8, 1, p. e54767 15 p.

    Research output: Contribution to journalArticleScientificpeer-review

  10. (+)-Dehydroabietic Acid, an Abietane-Type Diterpene, Inhibits Staphylococcus aureus Biofilms in Vitro

    Fallarero, A., Skogman, M., Kujala, J., Rajaratnam, M., Moreira, V. M., Yli-Kauhaluoma, J. & Vuorela, P., Jun 2013, In : International Journal of Molecular Sciences. 14, 6, p. 12054-12072 19 p.

    Research output: Contribution to journalArticleScientificpeer-review

View all (239) »

Latest activities

  1. EPIC-hankkeen loppuseminaari

    Jari Yli-Kauhaluoma (Chair)
    17 May 2019

    Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

  2. Design of selective NCX inhibitors for chronic treatments and acute on-off use

    Jari Yli-Kauhaluoma (Pre-examiner)
    14 May 2019

    Activity: Examination typesPre-examiner of doctoral thesis

  3. Pharmaceutical Chemistry at the Faculty of Pharmacy

    Jari Tapani Yli-Kauhaluoma (Speaker)
    3 May 2019

    Activity: Talk or presentation typesOral presentation

View all (386) »

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