Adrian Goldman

Person

Description of research and teaching

More than 50%  of current drugs affect membrane proteins and membrane protein systems.  It is thus clear that membranes and the proteins embedded in/associated  with them are key both biologically and medicinally. The proteins and  protein complexes in the membrane create electrochemical gradients,  mediate self:non-self interactions, and control the passage of molecules  and responses to extracellular signals. Despite this, such systems have  been less thoroughly studied than soluble proteins (Engelman, 2005, Nature, 438,  578-80). Steady advances in techniques have made it possible to study  them in lower amounts and with more spatial and temporal precision than  before.

 

Our work, which aims at spatial cellular/structural biology, thus  focuses on proteins and protein complexes that are at and close to the  cell surface, looking at at neuronal protein interactions  (e.g.  GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and at host-pathogen  interactions, such as those involving trimeric autotransporters, factor H  and complement. 

 

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Further information on the affiliationPrincipal Investigator

Latest publications

  1. A high-throughput method for orthophosphate determination of thermostable membrane-bound pyrophosphatase activity

    Vidilaseris, K., Kellosalo, J. & Goldman, A. 14 Feb 2018 In : Analytical Methods. 10, 6, p. 646-651 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  2. Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens

    Hassan, K. A., Liu, Q., Elbourne, L. D. H., Ahmad, I., Sharples, D., Naidu, V., Chan, C. L., Li, L., Harborne, S. P. D., Pokhrel, A., Postis, V. L. G., Goldman, A., Henderson, P. J. F. & Paulsen, I. T. 2018 In : Research in Microbiology.

    Research output: Contribution to journalArticleScientificpeer-review

  3. Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure

    Parmar, M., Rawson, S., Scarff, C. A., Goldman, A., Dafforn, T. R., Muench, S. P. & Postis, V. L. G. 2018 In : Biochimica et Biophysica Acta. Biomembranes. 1860, 2, p. 378 - 383

    Research output: Contribution to journalArticleScientificpeer-review

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Latest activities

  1. International Centre for Genetic Engineering & Biotechnology

    Goldman, A. (Visiting researcher)
    24 Nov 2016

    Activity: Visiting an external institutionAcademic visit to other institution

  2. Bose Inst, Bose Institute, Dept Phys

    Goldman, A. (Visiting researcher)
    22 Nov 2016

    Activity: Visiting an external institutionAcademic visit to other institution

  3. Indian Inst Sci, Indian Institute of Science (IISC) - Banglore, Ctr High Energy Phys

    Goldman, A. (Visiting researcher)
    20 Nov 2016

    Activity: Visiting an external institutionAcademic visit to other institution

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Education

Fil. toht., biotieteet, biokemia

ID: 19876