Adrian Goldman

Person

Description of research and teaching

More than 50%  of current drugs affect membrane proteins and membrane protein systems.  It is thus clear that membranes and the proteins embedded in/associated  with them are key both biologically and medicinally. The proteins and  protein complexes in the membrane create electrochemical gradients,  mediate self:non-self interactions, and control the passage of molecules  and responses to extracellular signals. Despite this, such systems have  been less thoroughly studied than soluble proteins (Engelman, 2005, Nature, 438,  578-80). Steady advances in techniques have made it possible to study  them in lower amounts and with more spatial and temporal precision than  before.

 

Our work, which aims at spatial cellular/structural biology, thus  focuses on proteins and protein complexes that are at and close to the  cell surface, looking at at neuronal protein interactions  (e.g.  GDNF-GFRα-RET, MANF, and neuronal LRR-proteins) and at host-pathogen  interactions, such as those involving trimeric autotransporters, factor H  and complement. 

 

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Further information on the affiliationPrincipal Investigator

Latest publications

  1. Accepted/In press
  2. Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies

    Wright, J., Muench, S. P., Goldman, A. & Baker, A., 17 Dec 2018, In : Biochemical Society Transactions. 46, 6, p. 1475-1484 10 p.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  3. Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study

    Liu, Y., Kaljunen, H., Pavic, A., Saarenpää, T., Himanen, J. P., Nikolov, D. B. & Goldman, A., 11 Jun 2018, In : PLoS One. 13, 6, 15 p., 0198291.

    Research output: Contribution to journalArticleScientificpeer-review

View all (88) »

Latest activities

  1. European Crystallographic Meeting

    Adrian Goldman (Attendee)
    22 Aug 201827 Aug 2018

    Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

  2. INPEC Meeting, Kolkata, India

    Adrian Goldman (Attendee)
    9 Nov 201711 Nov 2017

    Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

  3. The 15th Finnish Microbial Pathogenesis Days

    Adrian Goldman (Attendee)
    21 Aug 201723 Aug 2017

    Activity: Participating in or organising an event typesPublic Talks

View all (47) »

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