David Fewer


Description of research and teaching

Some of the most potent pharmaceuticals are derived from natural products. These small molecules are produced by a diverse selection of organisms, especially bacteria, fungi, and plants. Cyanobacteria are found in freshwater lakes, reservoirs and ponds worldwide. They  are infamous producers of toxins and are linked to the death of wild and domestic animals. However, they are also a prolific and promising source of biologically active natural products. My research focuses on how cyanobacteria produce these compounds. I am interested in the genome driven discovery and natural products. I use a combination of molecular biology, genomics and analytical chemistry to guide the discovery of new biological active compounds from cyanobacteria.


Highlighted publications

  1. A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

    Parajuli, A., Kwak, D. H., Dalponte, L., Leikoski, N., Galica, T., Umeobika, U., Trembleau, L., Bent, A., Sivonen, K., Wahlsten, M., Wang, H., Rizzi, E., De Bellis, G., Naismith, J., Jaspars, M., Liu, X., Houssen, W. & Fewer, D. P. 7 Mar 2016 In : Angewandte Chemie (International Edition). 55, 11, p. 3596-3599 4 p.

    Research output: Scientific - peer-reviewArticle

  2. Natural Product Biosynthetic Diversity and Comparative Genomics of the Cyanobacteria.

    Dittmann, E., Gugger, M., Sivonen, A. K. & Fewer, D. P. 5 Oct 2015 In : Trends in Microbiology. 23, 10, p. 642-652 11 p.

    Research output: Scientific - peer-reviewReview Article

  3. Genome mining expands the chemical diversity of the cyanobactin family to include highly modified linear peptides

    Leikoski, N., Liu, L., Jokela, J., Wahlsten, M., Gugger, M., Calteau, A., Permi, P., Kerfeld, C., Sivonen, K. & Fewer, D. P. 2013 In : Chemistry & Biology. 20, 8, p. 1033-1043 11 p.

    Research output: Scientific - peer-reviewArticle

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Highlighted activities

  1. Pasteur Institute

    Fewer, D. (Visiting researcher)
    18 Aug 201022 Aug 2010

    Activity: Visiting an external institutionAcademic visit to other institution

  2. Café scientifique

    Fewer, D. (Speaker: Presenter)
    21 Apr 2010

    Activity: Participating in or organising an eventPublic Talks

  3. 8th European Workshop on Molecular Biology of Cyanobacteria

    Fewer, D. (Scientific Committee Member)
    28 Aug 20111 Sep 2011

    Activity: Participating in or organising an eventOrganisation and participation in conferences, workshops, courses, seminars

View all (47) »

Highlighted prizes

  1. FEMS/ESCMID Research Fellow 2010

    David Fewer (Recipient), 2010

    Prize: Prizes and awards

View all (2) »



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