Hannes Lohi

Person

Description of research and teaching

Our research is focused on the development of canine models of human complex diseases. Our novel approach takes advantage of an experiment initiated by man 15,000 years ago, taming of the wolf and, more recently, generating 400 strictly inbred pure dog breeds.  Canine purebreeding has resulted in highly uniform genomes within each breed, in which the “noise” of background genetic variation is reduced making it easier to detect genetic “signals” that contribute to disease.  That alone would not be very helpful without the fact that several of the essential components of most disease phenotypes can be found and measured in dogs. Dog is a large animal and clinically and physiologically close to human than typical laboratory rodent models. Dogs develop biologically analogous, if not homologous, conditions to human genetic disorders. Canine disorders usually respond to human medications and also other clinical and phenomenological studies suggest that these traits may share biological mechanisms across species. We aim to utilize this unique genetic system to identify new genes for morphology, behavior and various disorders.  Towards our aims, we have established one of the largest Dog DNA Banks in the world with ~60 000 samples from 330 different breeds.

Although we work with many genetic traits in dogs, our research focuses on neurological and neurobehavioral conditions such as common epilepsy and anxiety.  We have already mapped several new loci and genes in these disorders and believe that the natural canine models provide clinically and physiologically relevant models to corresponding human diseases. Comparison of the identified loci, genes and pathways across species will establish dogs as novel therapeutic models to understand the molecular pathogenesis of these complex traits. Meanwhile, breeders will benefit from the new DNA markers developed to identify the carriers for improved breeding plans. Dr Lohi has successfully developed the first advanced gene panel test for dogs, MyDogDNA test (www.mydogdna.com), as an efficient tool for veterinaary diagnostics and breeding programs through his partially owned private company, Genoscoper  Ltd).

More on our research:

www.koirangeenit.fi

www.kissangeenit.fi

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Further information on the affiliationResearch Programs Unit, Molecular Neurology, Faculty of Medicine; Department of Veterinary Biosciences, Faculty of Veterinary Medicine

Highlighted publications

  1. Assembly and Analysis of Unmapped Genome Sequence Reads Reveal Novel Sequence and Variation in Dogs

    Holden, L. A., Arumilli, M., Hytonen, M. K., Hundi, S., Salojärvi, J., Brown, K. H. & Lohi, H., 18 Jul 2018, In : Scientific Reports. 8, 11 p., 10862.

    Research output: Contribution to journalArticleScientificpeer-review

  2. Skin microbiota and allergic symptoms associate with exposure to environmental microbes

    Lehtimaki, J., Sinkko, H., Hielm-Bjorkman, A., Salmela, E., Tiira, K., Laatikainen, T., Mäkelainen, S., Kaukonen, M., Uusitalo, L., Hanski, I., Lohi, H. & Ruokolainen, L., 8 May 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 19, p. 4897-4902 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  3. Myotonia congenita in a Labrador Retriever with truncated CLCN1

    Quitt, P. R., Hytönen, M. K., Matiasek, K., Rosati, M., Fischer, A. & Lohi, H., 19 Jun 2018, In : Neuromuscular Disorders. 28, 7, p. 597-605 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  4. Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease

    Kaukonen, M., Woods, S., Ahonen, S., Lemberg, S., Hellman, M., Hytönen, M. K., Permi, P., Glaser, T. & Lohi, H., 29 May 2018, In : Cell Reports. 23, 9, p. 2643-2652 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  5. Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs

    Donner, J., Anderson, H., Davison, S., Hughes, A. M., Bouirmane, J., Lindqvist, J., Lytle, K. M., Ganesan, B., Ottka, C., Ruotanen, P., Kaukonen, M., Forman, O. P., Fretwell, N., Cole, C. A. & Lohi, H., Apr 2018, In : PLoS Genetics. 14, 4, 20 p., 1007361.

    Research output: Contribution to journalArticleScientificpeer-review

  6. Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine

    Puurunen, J., Tiira, K., Vapalahti, K., Lehtonen, M., Hanhineva, K. & Lohi, H., 29 Oct 2018, In : Scientific Reports. 8, 12 p., 15976.

    Research output: Contribution to journalArticleScientificpeer-review

  7. MKLN1 splicing defect in dogs with lethal acrodermatitis

    Bauer, A., Jagannathan, V., Hoegler, S., Richter, B., McEwan, N. A., Thomas, A., Cadieu, E., Andre, C., Hytonen, M. K., Lohi, H., Welle, M. M., Roosje, P., Mellersh, C., Casal, M. L. & Leeb, T., Mar 2018, In : PLoS Genetics. 14, 3, 14 p., 1007264.

    Research output: Contribution to journalArticleScientificpeer-review

  8. Generalized myoclonic epilepsy with photosensitivity in juvenile dogs caused by a defective DIRAS family GTPase 1

    Wielaender, F., Sarviaho, R., James, F., Hytönen, M., Cortez, M., Kluger, G., Koskinen, L., Arumilli, M., Kornberg, M., Bathen-Noethen, A., Tipold, A., Rentmeister, K., Bhatti, S., Huelsmeyer, V., Boettcher, I. C., Taestensen, C., Flegel, T., Dietschi, E., Leeb, T., Matiasek, K. & 2 othersFischer, A. & Lohi, H., 7 Mar 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 10, p. 2669-2674 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  9. ANLN truncation causes a familial fatal acute respiratory distress syndrome in Dalmatian dogs

    Holopainen, S., Hytonen, M. K., Syrja, P., Arumilli, M., Jarvinen, A-K., Rajamaki, M. & Lohi, H., Feb 2017, In : PLoS Genetics. 13, 2, 12 p., 1006625.

    Research output: Contribution to journalArticleScientificpeer-review

  10. FEELnc: a tool for long non-coding RNA annotation and its application to the dog transcriptome

    Wucher, V., Legeai, F., Hedan, B., Rizk, G., Lagoutte, L., Leeb, T., Jagannathan, V., Cadieu, E., David, A., Lohi, H., Cirera, S., Fredholm, M., Botherel, N., Leegwater, P. A. J., Le Beguec, C., Fieten, H., Johnson, J., Alfoldi, J., Andre, C., Lindblad-Toh, K. & 2 othersHitte, C. & Derrien, T., 5 May 2017, In : Nucleic Acids Research. 45, 8, 12 p., e57.

    Research output: Contribution to journalArticleScientificpeer-review

  11. Early weaning increases aggression and stereotypic behaviour in cats

    Ahola, M. K., Vapalahti, K. & Lohi, H., 4 Sep 2017, In : Scientific Reports. 7, 9 p., 10412.

    Research output: Contribution to journalArticleScientificpeer-review

  12. Canine models of human rare disorders

    Hytönen, M. K. & Lohi, H., 28 Sep 2016, In : Rare Diseases. 4, 1, 6 p., 1241362.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  13. Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes

    Hytönen, M. K., Arumilli, M., Lappalainen, A. K., Owczarek-Lipska, M., Jagannathan, V., Hundi, S., Salmela, E., Venta, P., Sarkiala, E., Jokinen, T., Gorgas, D., Kere, J., Nieminen, P., Drögemüller, C. & Lohi, H., 17 May 2016, In : PLoS Genetics. 12, 5, 20 p., e1006037.

    Research output: Contribution to journalArticleScientificpeer-review

  14. A Missense Change in the ATG4D Gene Links Aberrant Autophagy to a Neurodegenerative Vacuolar Storage Disease

    Kyostila, K., Syrja, P., Jagannathan, V., Chandrasekar, G., Jokinen, T. S., Seppala, E. H., Becker, D., Drogemuller, M., Dietschi, E., Drogemuller, C., Lang, J., Steffen, F., Rohdin, C., Jaderlund, K. H., Lappalainen, A. K., Hahn, K., Wohlsein, P., Baumgartner, W., Henke, D., Oevermann, A. & 3 othersKere, J., Lohi, H. & Leeb, T., Apr 2015, In : PLoS Genetics. 11, 4, 22 p., 1005169.

    Research output: Contribution to journalArticleScientificpeer-review

  15. Identification of a common risk haplotype for canine idiopathic epilepsy in the ADAM23 gene

    Koskinen, L. L. E., Seppälä, E. H., Belanger, J. M., Arumilli, M., Hakosalo, O., Jokinen, P., Nevalainen, E. M., Viitmaa, R., Jokinen, T. S., Oberbauer, A. M. & Lohi, H., 2015, In : BMC Genomics. 16, 10 p., 465.

    Research output: Contribution to journalArticleScientificpeer-review

  16. Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease

    Wilbe, M., Kozyrev, S. V., Farias, F. H. G., Bremer, H. D., Hedlund, A., Pielberg, G. R., Seppala, E. H., Gustafson, U., Lohi, H., Carlborg, O., Andersson, G., Hansson-Hamlin, H. & Lindblad-Toh, K., Jun 2015, In : PLoS Genetics. 11, 6, 27 p., 1005248.

    Research output: Contribution to journalArticleScientificpeer-review

  17. Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders

    Donner, J., Kaukonen, M., Anderson, H., Moller, F., Kyostila, K., Sankari, S., Hytonen, M., Giger, U. & Lohi, H., 15 Aug 2016, In : PLoS One. 11, 8, 18 p., 0161005.

    Research output: Contribution to journalArticleScientificpeer-review

  18. A SEL1L Mutation Links a Canine Progressive Early-Onset Cerebellar Ataxia to the Endoplasmic Reticulum-Associated Protein Degradation (ERAD) Machinery

    Kyöstilä, K., Cizinauskas, S., Seppälä, E., Suhonen, E., Jeserevics, J., Sukura, A., Syrjä, P. E. S. & Lohi, H., 2012, In : PLoS Genetics. 8, p. e1002759 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  19. Novel origins of copy number variation in the dog genome.

    Berglund, J., Nevalainen, E., Molin, A. M., Perloski, M., LUPA consortium, Andre, C., Zody, M. C., Sharpe, T., Hitte, C., Lindblad-Toh, K., Lohi, H. T. & Webster, M., 2012, In : Genome Biology. 13, 8, p. R73 41 p.

    Research output: Contribution to journalArticleScientificpeer-review

  20. Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping

    Vaysse, A., Ratnakumar, A., Derrien, T., Axelsson, E., Pielberg, G. R., Sigurdsson, S., Fall, T., Seppala, E. H., Hansen, M. S. T., Lawley, C. T., Karlsson, E. K., Bannasch, D., Vila, C., Lohi, H., Galibert, F., Fredholm, M., Haggstrom, J., Hedhammar, A., Andre, C., Lindblad-Toh, K. & 3 othersHitte, C., Webster, M. T. & LUPA Consortium, 2011, In : PLoS Genetics. 7, 10, p. e1002316 21 p.

    Research output: Contribution to journalArticleScientificpeer-review

  21. Variation in Genes Related to Cochlear Biology Is Strongly Associated with Adult-Onset Deafness in Border Collies

    Yokoyama, J. S., Lam, E. T., Ruhe, A. L., Erdman, C. A., Robertson, K. R., Webb, A. A., Williams, D. C., Chang, M. L., Hytönen, M. K., Lohi, H., Hamilton, S. P. & Neff, M. W., 1 Sep 2012, In : PLoS Genetics. 8, 9, p. e1002898 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  22. LGI2 Truncation Causes a Remitting Focal Epilepsy in Dogs

    Seppälä, E. H., Jokinen, T. S., Fukata, M., Fukata, Y., Webster, M. T., Karlsson, E. K., Kilpinen, S. K., Steffen, F., Dietschi, E., Leeb, T., Eklund, R., Zhao, X., Rilstone, J. J., Lindblad-Toh, K., Minassian, B. A. & Lohi, H., 2011, In : PLoS Genetics. 7, 7, p. e1002194 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  23. Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex

    Wilbe, M., Jokinen, P., Truve, K., Seppälä, E. H., Karlsson, E. K., Biagi, T., Hughes, A., Bannasch, D., Andersson, G., Hansson-Hamlin, H., Lohi, H. & Lindblad-Toh, K., 2010, In : Nature Genetics. 42, 3, p. 250-254

    Research output: Contribution to journalArticleScientificpeer-review

  24. A mutation in hairless dogs implicates FOXI3 in ectodermal development

    Drögemuller, C., Karlsson, E. K., Hytönen, M. K., Perloski, M., Dolf, G., Sainio, K., Lohi, H., Lindblad-Toh, K. & Leeb, T., 2008, In : Science. 321, 5895, p. 1462 1 p.

    Research output: Contribution to journalArticleScientificpeer-review

  25. Expanded repeat in canine epilepsy

    Lohi, H., Young, E. J., Fitzmaurice, S. N., Rusbridge, C., Chan, E. M., Vervoort, M., Turnbull, J., Zhao, X. C., Ianzano, L., Paterson, A. D., Sutter, N. B., Ostrander, E. A., Andre, C., Shelton, G. D., Ackerley, C. A., Scherer, S. W. & Minassian, B. A., 2005, In : Science. 307, p. 81-81 1 p.

    Research output: Contribution to journalArticleScientificpeer-review

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Latest activities

  1. Opponent of doctoral dissertation

    Hannes Lohi (Supervisor)
    24 Aug 2018

    Activity: Examination typesOpponent of doctoral dissertation

  2. Terveydeksi: Koira tieteen palveluksessa

    Hannes Lohi (Speaker)
    27 Oct 2017

    Activity: Talk or presentation typesInvited talk

  3. Chair: Session 3: Neurology

    Hannes Tapani Lohi (Speaker)
    20 May 201724 May 2017

    Activity: Talk or presentation typesInvited talk

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Highlighted prizes

  1. Helsingin kaupungin tiedepalkinto 2013

    Hannes Lohi (Recipient), 6 Jun 2013

    Prize: Prizes and awards

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Latest projects

  1. The effect of pressure vest on noise phobic dogs in a double-blinded experiment

    Pekkin, A., Hänninen, L., Koskela, A., Tiira, K., Pöytäkangas, M., Lohi, H. & Valros, A.

    Unknown funder

    01/11/201331/10/2017

    Project: Research project

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