Jari Yli-Kauhaluoma

Person

Description of research and teaching

Research interests

Medicinal chemistry of

  • combating bacterial biofilms and Gram-negative bacteria with novel antimicrobial compounds
  • chemical induction of cellular reprogramming and differentiation
  • targeting intracellular protozoan parasites (Leishmania sp., Plasmodium falciparum)
  • bioactive terpenes of marine and forest sources
  • novel synthesis methods of bioactive compounds

Topics of recent publications 

  • Design, synthesis and biological activity of compounds targeted to Pim and the C1 domain of PKC
  • Terpene-derived compounds as antileishmanial agents
  • Design, synthesis and biological activity of heterocycles and terpenoids against Chlamydia pneumoniae
  • Benzo[cd]azulenes: synthesis of azulene, heptafulvene, and tropone derivatives and activity against Pim kinases

Teaching activities

  • Organizing the extensive organic chemistry curriculum in the Viikki Campus for the students of pharmaceutical sciences, biotechnology, molecular biosciences, microbiology, food chemistry and others interested in organic chemistry for life scientists.

Recent administrative duties

  • Head of the Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, 2014-
  • President of the Finnish Chemical Society, 2016-2018
  • Director of the Pharmacy Section of the FinPharma Doctoral Program, 2012-13
  • Vice Co-ordinator of the EC-FP7 projects MAREX, 2010-14 & GLORIA, 2013-18
  • Member of the CBRN Division of the Scientific Advisory Board for Defence, 2006-
  • Member of the Pharmacopoeia Committee of the Finnish Medicines Agency, 2010-
  • Member of the Expert Panel: FWO Research Foundation - Flanders, Belgium, 2012-2015
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Further information on the affiliationProfessor of Medicinal Chemistry

Highlighted publications

  1. New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

    Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero , A. & Moreira, V. M. 21 Jul 2015 In : European Journal of Medicinal Chemistry. 102, p. 68-79 12 p.

    Research output: Scientific - peer-reviewArticle

  2. A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides

    Keurulainen, L., Vahermo, M., Puente-Felipe, M., Sandoval-Izquierdo, E., Crespo-Fernandez, B., Guijarro-Lopez, L., Huertas-Valentin, L., de las Heras-Duena, L., Leino, T. O., Siiskonen, A., Balla-Pages, L., Sanz, L. M., Castaneda-Casado, P., Belen Jimenez-Diaz, M., Martinez-Martinez, M. S., Viera, S., Kiuru, P., Calderon, F. & Yli-Kauhaluoma, J. 11 Jun 2015 In : Journal of Medicinal Chemistry. 58, 11, p. 4573-4580 8 p.

    Research output: Scientific - peer-reviewArticle

  3. Pyrofosfaatti lääketieteessä

    Goldman, A., Boije af Gennäs, P. G., Xhaard, H. G. M., Meri, S. K. & Yli-Kauhaluoma, J. T. 2016 In : Duodecim. 132, 12, p. 1111-1117 7 p.

    Research output: Scientific - peer-reviewArticle

  4. Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo

    Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E. Feb 2016 In : Journal of Natural Products. 79, 2, p. 274-280 7 p.

    Research output: Scientific - peer-reviewArticle

  5. Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

    Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S. Feb 2016 In : Journal of Natural Products. 79, 2, p. 362-368 7 p.

    Research output: Scientific - peer-reviewArticle

  6. Design and Synthesis of 2-Arylbenzimidazoles and Evaluation of Their Inhibitory Effect against Chlamydia pneumoniae.

    Keurulainen, L., Salin, O., Siiskonen, A., Kern, J. M., Alvesalo, J. K. O., Kiuru, P., Maass, M., Yli-Kauhaluoma, J. & Vuorela, P. 2010 In : Journal of Medicinal Chemistry. 53, 21, p. 7664-7674 11 p.

    Research output: Scientific - peer-reviewArticle

  7. The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

    Talman, V., Amadio, M., Osera, C., Sorvari, S., Boije af Gennäs, G., Yli-Kauhaluoma, J., Rossi, D., Govoni, S., Collina, S., Ekokoski, E., Tuominen, R. K. & Pascale, A. 2013 In : Pharmacological Research. 73, p. 44-54 11 p.

    Research output: Scientific - peer-reviewArticle

  8. Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed Cells

    Kiriazis, A., Vahakoski, R. L., Santio, N. M., Arnaudova, R., Eerola, S. K., Rainio, E-M., Aumuller, I. B., Yli-Kauhaluoma, J. & Koskinen, P. J. 2013 In : PLoS One. 8, 2, p. e55409 13 p.

    Research output: Scientific - peer-reviewArticle

  9. Albumin Stimulates the Activity of the Human UDP-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects are Enzyme and Substrate Dependent

    Manevski, N., Troberg, J., Svaluto-Moreolo, P., Dziedzic, K., Yli-Kauhaluoma, J. & Finel, M. 2013 In : PLoS One. 8, 1, p. e54767 15 p.

    Research output: Scientific - peer-reviewArticle

  10. (+)-Dehydroabietic Acid, an Abietane-Type Diterpene, Inhibits Staphylococcus aureus Biofilms in Vitro

    Fallarero, A., Skogman, M., Kujala, J., Rajaratnam, M., Moreira, V. M., Yli-Kauhaluoma, J. & Vuorela, P. Jun 2013 In : International Journal of Molecular Sciences. 14, 6, p. 12054-12072 19 p.

    Research output: Scientific - peer-reviewArticle

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Latest activities

  1. Member of doctoral thesis committee: Biofilm degrading enzymes, poly-β-1,6-acetylglucosaminidase and alginate lyase

    Yli-Kauhaluoma, J. (Supervisor)
    20172021

    Activity: ExaminationMember of doctoral thesis committee / follow-up group

  2. Evaluation of Research Proposals, University of Calabria (External organisation)

    Yli-Kauhaluoma, J. (Board member)
    16 Nov 2017

    Activity: MembershipMembership or other role in review committee

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Education

Fil. toht., kemia

ID: 62274