Jukka Finne

Person

Description of research and teaching

Cell surface glycoconjugates in cell interactions of the nervous system and in bacterial adhesion

Polysialic acid is a neurodevelopmental antigen shared by the neural cell adhesion molecule NCAM and capsular polysaccharides of meningitis-causing bacteria. Polysialic acid regulates cell interactions in neural and other tissues during development, and in learning and memory consolidation. Polysialic acid has a central role in many cellular functions, such as migration, cytokine response and cell contact-dependent differentiation. Altered levels of polysialic acid are detected in various neurological diseases, as well as malignancies including neuroblastoma. The objectives of the project are to elucidate the molecular basis of the regulation of polysialic acid expression and to investigate whether polysialic acid could be used as a target for cytotoxicity of neuroblastoma cells.

Meningitis-causing and other pathogenic bacteria attach to their tissue receptors by adhesin molecules binding to specific carbohydrate ligands on cell surfaces. Characterisation of these molecular interactions sheds light on the pathogenic mechanisms of bacterial diseases, and enables the development of new vaccines and new types of drugs that interfere with bacterial adhesion. We are studying carbohydrate-binding proteins to determine their interaction mechanisms and to develop inhibitors of adhesion that could be used as antibacterials.

See also Glycoscience Group

Education information

Found qualified and competent for Professor of Biochemistry and Pharmaceutical Chemistry, Åbo Akademi, 1982
Found qualified and competent for Professor of Biochemistry, University of Turku, 1983
Found qualified and competent for Professor of Physiological Chemistry, University of Kuopio, 1985
Found qualified and competent for Professor of Medical Chemistry, University of Turku, 1986
Found qualified and competent for Professor of Glycobiology, University of Helsinki, 2007
Found qualified and competent for Professor of Cell and Molecular Biology, University of Helsinki, 2009

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Curriculum Vitae

Latest publications

  1. Rationally designed chemically modified glycodendrimer inhibits Streptococcus suis adhesin SadP at picomolar concentrations

    Haataja, S., Verma, P., Fu, O., Papageorgiou, A. C., Pöysti, S., Pieters, R. J., Nilsson, U. J. & Finne, J., 2018, In : Chemistry: A European Journal. 24, 8, p. 1905-1912 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  2. Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells

    Lehti, T. A., Pajunen, M. I., Skog, M. S. & Finne, J., 4 Dec 2017, In : Nature Communications. 8, 12 p., 1915.

    Research output: Contribution to journalArticleScientificpeer-review

  3. Phages crossing the border to eukaryotes: Is there a gateway for bacteriophages to get access to the interior of eukaryotic cells?

    Lehti, T. A. & Finne, J., 4 Dec 2017, In : Nature Microbiology.

    Research output: Contribution to journalComment/debateProfessional

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Latest activities

  1. Austrian Research Fund (External organisation)

    Jukka Finne (Assessment)
    2018

    Activity: Membership typesMembership or other role in review committee

  2. Julkaisufoorumi/Publication Forum (External organisation)

    Jukka Finne (Member)
    20182021

    Activity: Membership typesMembership or other role in national/international committee, council, board

  3. Member of the Board of the University Helsinki branch of the Finnish Union of University Professors

    Jukka Finne (Participant)
    2018

    Activity: Other activity typesTypes for other activities - Other

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