Lauri Aaltonen

Person

Description of research and teaching

Tumor Genomics research group (Kasvaingenomiikan tutkimusryhmä)

Tumor Genomics research group (Kasvaingenomiikan tutkimusryhmä) works in close contact with clinical researchers to unravel molecular background of human tumor susceptibility, utilizing tools provided by the Human Genome Project and other recent advances in biosciences. The aim is to create information on human tumorigenesis and to facilitate cancer prevention, diagnosis, and treatment.

Research

The research of the group focuses on human tumor susceptibility. Particular focus of interest has been hereditary colorectal cancer, where the group has contributed to several key discoveries; see the link for selected publications. Molecular background events in microsatellite unstable colorectal cancer is one of our long term interests.

More recently, we have identified and characterized a novel cancer predisposition syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC), and with our collaborators identified the gene behind the condition as fumarase (see publications). The most recent gene discovery is identification of germline mutations in the AIP gene in pituitary adenoma predisposition, published in Science 2006.

The future focus is in utilizing registry-based approaches to identify unique cancer family materials, for chip-based analysis and disease gene identification. Finland provides excellent resources for this work, and an effort to systematically utilize the National Cancer Registry (operating since 1953) and Population Registry databases in cancer gene identification is being launched.

This group is also one of six groups forming the Academy of Finland 's Center of Excellence in Translational Genome-Scale Biology, as well as a member of the Nordic Network of Excellence in Disease Genetics 2004-2009. MD PhD Maija Kiuru from the Aaltonen group received the University of Helsinki Thesis Prize 2004. The group was short-listed for the 2005 Descartes Prize.

The group was also honoured with the University of Helsinki Occupational Safety and Health Award 2005 (Yliopiston työsuojelupalkinto 2005). This prize is awarded yearly by the Labour Protection Committee of the University of Helsinki for improving quality, safety, and atmosphere of the working environment.

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Curriculum Vitae

Highlighted publications

  1. Clues to the pathogenesis of familial colorectal cancer

    AALTONEN, L. A., Peltomäki, P., LEACH, F. S., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., Järvinen, H., POWELL, S. M., JEN, J., HAMILTON, S. R., PETERSEN, G. M., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A. 1993 In : Science. 260, p. 812-816 5 p.

    Research output: Scientific - peer-reviewArticle

  2. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

    Hemminki, A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., Salovaara, R., Nyström-Lahti, M., de la Chapelle, A. & Aaltonen, L. A. 1994 In : Nature Genetics. 8, p. 405-410 6 p.

    Research output: Scientific - peer-reviewArticle

  3. Somatic microsatellite mutations as molecular tumor clocks

    Shibata, D., Navidi, W., Salovaara, R., Li, Z. H. & Aaltonen, L. A. 1996 In : Nature Medicine. 2, p. 676-681 6 p.

    Research output: Scientific - peer-reviewArticle

  4. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

    Hemminki, A., Tomlinson, I., Markie, D., Jarvinen, H., Sistonen, P., Bjorkqvist, A. M., Knuutila, S., Salovaara, R., Bodmer, W., Shibata, D., delaChapelle, A. & Aaltonen, L. A. 1997 In : Nature Genetics. 15, p. 87-90 4 p.

    Research output: Scientific - peer-reviewArticle

  5. A serine/threonine kinase gene defective in Peutz-Jegheus syndrome

    Hemminki, A., Markie, D., Tomlinson, I., Avizienyte, E., Roth, S., Loukola, A., Bignell, G., Warren, W., Aminoff, M., Hoglund, P., Jarvinen, H., Kristo, P., Pelin, K., Ridanpaa, M., Salovaara, R., Toro, T., Bodmer, W., Olschwang, S., Olsen, A. S., Stratton, M. R., de la Chapelle, A. & Aaltonen, L. A. 1998 In : Nature Malaysiana.. 391, p. 184-187 4 p.

    Research output: Scientific - peer-reviewArticle

  6. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease

    Aaltonen, L. A., Salovaara, R., Kristo, P., Canzian, F., Hemminki, A., Peltomäki, P., Chadwick, R. B., Kääriäinen, H., Eskelinen, M., Jarvinen, H., Mecklin, J. P., de la Chapelle, A., Percesepe, A., Ahtola, H., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J. & ValKamo, E. 1998 In : New England Journal of Medicine. 338, 21, p. 1481-1487 7 p.

    Research output: Scientific - peer-reviewArticle

  7. Mutations in the SMAD4/DPC4 gene in juvenile polyposis

    Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Tomlinson, I. P. M., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M. & Aaltonen, L. A. 1998 In : Informing Science. 280, p. 1086-1088 3 p.

    Research output: Scientific - peer-reviewArticle

  8. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

    Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V., Aaltonen, L. A. & Multiple Leiomyoma Consortium 2002 In : Nature Genetics. 30, p. 406-410 5 p.

    Research output: Scientific - peer-reviewArticle

  9. Pituitary adenoma predisposition caused by germline mutations in the AIP gene

    Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., De Menis, E., Mäkinen, M. J., Launonen, V., Karhu, A. & Aaltonen, L. A. 2006 In : Science. 312, 5777, p. 1228-1230 3 p.

    Research output: Scientific - peer-reviewArticle

  10. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

    Tuupanen, S., Turunen, M., Lehtonen, R., Hallikas, O., Vanharanta, S., Kivioja, T., Björklund, M., Wei, G., Yan, J., Niittymäki, I., Mecklin, J-P., Järvinen, H., Ristimäki, A., Di-Bernardo, M., East, P., Carvajal-Carmona, L., Houlston, R. S., Tomlinson, I., Palin, K., Ukkonen, E., Karhu, A., Taipale, J. & Aaltonen, L. A. 2009 In : Nature Genetics. 41, 8, p. 885-890 6 p.

    Research output: Scientific - peer-reviewArticle

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Latest activities

  1. Doctoral thesis supervision / Heinonen

    Aaltonen, L. (Supervisor)
    2015 → …

    Activity: ExaminationSupervisor or co-supervisor of doctoral thesis

  2. Doctoral thesis supervision / Mäkinen

    Aaltonen, L. (Supervisor)
    2015

    Activity: ExaminationSupervisor or co-supervisor of doctoral thesis

  3. Doctoral thesis supervision / Donner

    Aaltonen, L. (Supervisor)
    2014 → …

    Activity: ExaminationSupervisor or co-supervisor of doctoral thesis

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Latest prizes

  1. ERC Advanced Grant

    Lauri Aaltonen (Recipient), 2010

    Prize: Prizes and awards

  2. Nominee for Descartes Prize

    Lauri Aaltonen (Recipient), 2005

    Prize: Prizes and awards

View all (6) »

Education

Lääketieteen tohtori

ID: 47518