Lauri Aaltonen

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  1. 1992
  2. EVIDENCE THAT THE MCC-APC GENE REGION IN 5Q21 IS NOT THE SITE FOR SUSCEPTIBILITY TO HEREDITARY NONPOLYPOSIS COLORECTAL-CARCINOMA

    PELTOMAKI, P., SISTONEN, P., MECKLIN, J. P., PYLKKANEN, L., AALTONEN, L., NORDLING, S., KERE, J., JARVINEN, H., HAMILTON, S. R., PETERSEN, G., KINZLER, K. W., VOGELSTEIN, B. & DELACHAPELLE, A., 1992, In : Cancer Research. 1992, 52, p. 4530-4533 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  3. 1993
  4. Clues to the pathogenesis of familial colorectal cancer

    AALTONEN, L. A., Peltomäki, P., LEACH, F. S., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., Järvinen, H., POWELL, S. M., JEN, J., HAMILTON, S. R., PETERSEN, G. M., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1993, In : Science. 260, p. 812-816 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  5. Genetic mapping of a locus predisposing to human colorectal cancer

    Peltomäki, P., AALTONEN, L. A., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., JARVINEN, H., GREEN, J. S., JASS, J. R., WEBER, J. L., LEACH, F. S., PETERSEN, G. M., HAMILTON, S. R., DELACHAPELLE, A. & VOGELSTEIN, B., 1993, In : Science. 260, p. 810-812 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  6. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history

    LOTHE, R. A., Peltomäki, P., MELING, G. I., AALTONEN, L. A., NYSTROMLAHTI, M., PYLKKANEN, L., HEIMDAL, K., ANDERSEN, T. I., MOLLER, P., ROGNUM, T. O., FOSSA, S. D., HALDORSEN, T., LANGMARK, F., BROGGER, A., DELACHAPELLE, A. & BORRESEN, A. L., 1993, In : Cancer Research. 53, p. 5849-5852 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  7. Läpimurto paksusuolisyövän geneettisen taustan selvittämisessä

    Peltomäki, P. T., Aaltonen, L. A., Mecklin, JP. & de la Chapelle, A., 1993, In : Duodecim. 109, p. 1367-1369

    Research output: Contribution to journalReview ArticleScientificpeer-review

  8. Microsatellite instability is associated with tumors that characterize the hereditary nonpolyposis colorectal carcinoma syndrome

    Peltomäki, P., LOTHE, R. A., AALTONEN, L. A., PYLKKANEN, L., Nyström-Lahti, M., SERUCA, R., DAVID, L., HOLM, R., RYBERG, D., HAUGEN, A., BROGGER, A., BORRESEN, A. L. & de la Chapelle, A., 1993, In : Cancer Research. 53, p. 5853-5855 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  9. Mutations of a MutS homolog in hereditary non-polyposis colorectal cancer

    LEACH, F. S., NICOLAIDES, N. C., PAPADOPOULOS, N., LIU, B., JEN, J., PARSONS, R., Peltomäki, P., SISTONEN, P., Aaltonen, L. A., NYSTROMLAHTI, M., GUAN, X. Y., ZHANG, J., MELTZER, P. S., YU, J. W., KAO, F. T., CHEN, D. J., CEROSALETTI, K. M., FOURNIER, R. E. K., TODD, S., LEWIS, T. & 15 othersLEACH, R. J., NAYLOR, S. L., WEISSENBACH, J., MECKLIN, J. P., Järvinen, H., PETERSEN, G. M., HAMILTON, S. R., GREEN, J., JASS, J., WATSON, P., LYNCH, H. T., TRENT, J. M., de la Chapelle, A., KINZLER, K. W. & VOGELSTEIN, B., 1993, In : Cell. 75, p. 1215-1225 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  10. 1994
  11. A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancel burden

    Aaltonen, L. A., SANKILA, R., MECKLIN, J. P., Järvinen, H., PUKKALA, E., Peltomäki, P. & de la Chapelle, A., 1994, In : Cancer Detection and Prevention. 18, p. 57-63 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  12. Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families

    Nyström-Lahti, M., Sistonen, P., Mecklin, J. P., Pylkkänen, L., Aaltonen, L. A., Järvinen, H., Weissenbach, J., de la Chapelle, A. & Peltomäki, P., 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, p. 6054-6058 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  13. Genes involved in hereditary nonpolyposis colorectal carcinoma

    Aaltonen, L. A. & Peltomäki, P. T., 1994, In : Anticancer Research. 14, p. 1657-1660

    Research output: Contribution to journalReview ArticleScientificpeer-review

  14. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

    Hemminki, A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., Salovaara, R., Nyström-Lahti, M., de la Chapelle, A. & Aaltonen, L. A., 1994, In : Nature Genetics. 8, p. 405-410 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  15. Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage

    Nyström-Lahti, M., PARSONS, R., SISTONEN, P., Pylkkänen, L., Aaltonen, L. A., LEACH, F. S., HAMILTON, S. R., WATSON, P., BRONSON, E., CAVALIERI, J., LYNCH, J., LANSPA, S., SMYRK, T., LYNCH, P., DROUHARD, T., KINZLER, K. W., VOGELSTEIN, B., LYNCH, H. T., de la Chapelle, A. & Peltomäki, P., 1994, In : American Journal of Human Genetics. 55, p. 659-665 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  16. Replication errors in benign and malignant tumors from hederitary nonpolyposis colorectal cancer patients

    Aaltonen, L. A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., JASS, J. R., GREEN, J. S., LYNCH, H. T., WATSON, P., TALLQVIST, G., JUHOLA, M., SISTONEN, P., HAMILTON, S. R., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1994, In : Cancer Research. 54, p. 1645-1648 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  17. 1995
  18. Founding mutations and Alu-mediated recombination in hereditary colon cancer

    Nyström-Lahti, M., KRISTO, P., NICOLAIDES, N. C., CHANG, S. Y., Aaltonen, L. A., MOISIO, A. L., Järvinen, H. J., MECKLIN, J. P., KINZLER, K. W., VOGELSTEIN, B., de la Chapelle, A. & Peltomäki, P., 1995, In : Nature Medicine. 1, 11, p. 1203-1206 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  19. Periytyvä syöpä

    Mecklin, J-P., Peltomäki, P. T., Aaltonen, L. A. & Kääriäinen, H., 1995, In : Suomen lääkärilehti. 50, 18-19, p. 2057-2064

    Research output: Contribution to journalReview ArticleScientificpeer-review

  20. 1996
  21. No evidence of microsatellite instability in bone tumors

    Tarkkanen, M., Aaltonen, L. A., Böhling, T. O., Kivioja, A. H., Karaharju, E., Elomaa, A. I. & Knuutila, Y. S., 1996, In : British Journal of Cancer. 74, p. 453-455

    Research output: Contribution to journalArticleScientificpeer-review

  22. Semiautomated assessment of loss of heterozygosity and replication error in tumors

    Canzian, F., Salovaara, R., Hemminki, A., Kristo, P., Chadwick, R. B., Aaltonen, L. A. & delaChapelle, A., 1996, In : Cancer Research. 56, p. 3331-3337 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  23. Somatic microsatellite mutations as molecular tumor clocks

    Shibata, D., Navidi, W., Salovaara, R., Li, Z. H. & Aaltonen, L. A., 1996, In : Nature Medicine. 2, p. 676-681 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  24. 1997
  25. Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome

    Marsh, D. J., Roth, S., Lunetta, K. L., Hemminki, A., Dahia, P. L. M., Sistonen, P., Zheng, Z. M., Caron, S., vanOrsouw, N. J., Bodmer, W. F., Cottrell, S. E., Dunlop, M. G., Eccles, D., Hodgson, S. V., Jarvinen, H., Kellokumpu, I., Markie, D., Neale, K., Phillips, R., Rozen, P. & 5 othersSyngal, S., Vijg, J., Tomlinson, I. P. M., Aaltonen, L. A. & Eng, C., 1997, In : Cancer Research. 57, p. 5017-5021 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  26. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

    Hemminki, A., Tomlinson, I., Markie, D., Jarvinen, H., Sistonen, P., Bjorkqvist, A. M., Knuutila, S., Salovaara, R., Bodmer, W., Shibata, D., delaChapelle, A. & Aaltonen, L. A., 1997, In : Nature Genetics. 15, p. 87-90 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  27. MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis

    Wu, Y., Nyström-Lahti, M., Osinga, J., Looman, M. W. G., Peltomäki, P., Aaltonen, L. A., de la Chapelle, A., Hofstra, R. M. W. & Buys, C. H. C. M., 1997, In : Genes, Chromosomes & Cancer. 18, p. 269-278 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  28. 1998
  29. A missense mutation in the BRCA2 gene in three siblings with ovarian cancer

    Roth, S., Kristo, P., Auranen, A., Shayeghi, M., Seal, S., Collins, N., Barfoot, R., Rahman, N., Klemi, P. J., Grenman, S., Sarantaus, L., Nevanlinna, H., Butzow, R., Ashworth, A., Stratton, M. R. & Aaltonen, L. A., 1998, In : British Journal of Cancer. 77, p. 1199-1202 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  30. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease

    Aaltonen, L. A., Salovaara, R., Kristo, P., Canzian, F., Hemminki, A., Peltomäki, P., Chadwick, R. B., Kääriäinen, H., Eskelinen, M., Jarvinen, H., Mecklin, J. P., de la Chapelle, A., Percesepe, A., Ahtola, H., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J. & ValKamo, E., 1998, In : New England Journal of Medicine. 338, 21, p. 1481-1487 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  31. Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene

    Hemminki, A., Hoglund, P., Pukkala, E., Salovaara, R., Jarvinen, H., Norio, R. & Aaltonen, L. A., 1998, In : Oncogene. 16, p. 681-684 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  32. Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability

    Percesepe, A., Kristo, P., Aaltonen, L. A., de Leon, M. P., de la Chapelle, A. & Peltomäki, P., 1998, In : Oncogene. 17, p. 157-163 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  33. Mutations in the SMAD4/DPC4 gene in juvenile polyposis

    Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Tomlinson, I. P. M., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M. & Aaltonen, L. A., 1998, In : Informing Science. 280, p. 1086-1088 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  34. Periytyvän paksusuolisyövän yleisyys ja molekyyligeneettinen seulonta Suomessa

    Aaltonen, L. A., Salovaara, R., Krio, P., Canzian, F., Hemminki, A., Percesepe, A., Peltomäki, P. T., de la Chapelle, A., Chadwick, R. B., Kääriäinen, H., Ahtola, H., Eskelinen, M., Härkönen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Järvinen, H. & Mecklin, J-P., 1998, In : Duodecim. 114, p. 2084-2085

    Research output: Contribution to journalReview ArticleScientificpeer-review

  35. Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3

    Olschwang, S., Markie, D., Seal, S., Neale, K., Phillips, R., Cottrell, S., Ellis, I., Hodgson, S., Zauber, P., Spigelman, A., Iwama, T., Loff, S., McKeown, C., Marchese, C., Sampson, J., Davies, S., Talbot, I., Wyke, J., Thomas, G., Bodmer, W. & 7 othersHemminki, A., Avizienyte, E., de la Chapelle, A., Aaltonen, L., Stratton, M., Houlston, R. & Tomlinson, I., 1998, In : Journal of Medical Genetics. 35, p. 42-44 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  36. Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors

    Avizienyte, E., Roth, S., Loukola, A., Hemminki, A., Lothe, R. A., Stenwig, A. E., Fossa, S. D., Salovaara, R. & Aaltonen, L. A., 1998, In : Cancer Research. 58, p. 2087-2090 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  37. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

    Hemminki, A., Markie, D., Tomlinson, S. J., Avizienyte, E., Roth, S., Loukola, A., Bignell, G., Warren, W., Aminoff, M., Höglund, P., Jarvinen, H., Kristo, P., Pelin, K., Ridanpaa, M., Salovaara, R., Toro, T., Bodmer, W., Olschwang, S., Olsen, AS., Stratton, MR. & 2 othersde la Chapelle, A. & Aaltonen, LA., 8 Jan 1998, In : Nature. 391, 6663, p. 184-187 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  38. 1999
  39. Cancer risk in mutation carriers of DNA-mismatch-repair genes

    Aarnio, M., Sankila, R., Pukkala, E., Salovaara, R., Aaltonen, L. A., de la Chapelle, A., Peltomäki, P., Mecklin, J. P. & Jarvinen, H. J., 1999, In : International Journal of Cancer. 81, p. 214-218 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  40. Epigenetic phenotypes distinguish microsatellite stable and unstable colorectal cancers

    Kuismanen, S. A., Holmberg, M. T., Salovaara, R., Schweizer, P., Aaltonen, L. A., de la Chapelle, A., Nyström-Lahti, M. & Peltomäki, P., 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, p. 12661-12666 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  41. LKB1 somatic mutations in sporadic tumors

    Avizienyte, E., Loukola, A., Roth, S., Hemminki, A., Tarkkanen, M., Salovaara, R., Arola, J., Butzow, R., Husgafvel-Pursiainen, K., Kokkola, A., Jarvinen, H. & Aaltonen, L. A., 1999, In : The American Journal of Pathology. 154, 3, p. 677-681 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  42. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer

    Ylikorkala, A., Avizienyte, E., Tomlinson, I. P. M., Tiainen, M., Roth, S., Loukola, A., Hemminki, A., Johansson, M., Sistonen, P., Markie, D., Neale, K., Phillips, R., Zauber, P., Twama, T., Sampson, J., Järvinen, H., Makela, T. P. & Aaltonen, L. A., 1999, In : Human Molecular Genetics. 8, p. 45-51 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  43. SMAD genes in juvenile polyposis

    Roth, S., Sistonen, P., Salovaara, R., Hemminki, A., Loukola, A., Johansson, M., Avizienyte, E., Cleary, K. A., Lynch, P., Amos, C. I., Kristo, P., Mecklin, J. P., Kellokumpu, I., Jarvinen, H. & Aaltonen, L. A., 1999, In : Genes, Chromosomes & Cancer. 26, 1, p. 54-61 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  44. The I1307K polymorphism of the APC gene in colorectal cancer

    Prior, TW., Chadwick, RB., Papp, AC., Arcot, AN., Isa, AM., Pearl, DK., Stemmermann, G., Percesepe, A., Loukola, A., Aaltonen, LA. & de la Chapelle, A., Jan 1999, In : Gastroenterology. 116, 1, p. 58-63 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  45. Strategies for screening for hereditary non-polyposis colorectal cancer

    Loukola, A., de la Chapelle, A. & Aaltonen, LA., Nov 1999, In : Journal of Medical Genetics. 36, 11, p. 819-822 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  46. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

    Riccio, A., Aaltonen, LA., Godwin, AK., Loukola, A., Percesepe, A., Salovaara, R., Masciullo, T., Genuardi, M., Paravatou-Petsotas, M., Bassi, DE., Ruggeri, BA., Klein-Szanto, AJP., Testa, T., Neri, G. & Bellacosa, A., Nov 1999, In : Nature Genetics. 23, 3, p. 266-268 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  47. Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer

    Loukola, A., Salovaara, R., Kristo, P., Moisio, AL., Kaariainen, H., Ahtola, H., Eskelinen, M., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Jarvinen, H., Mecklin, JP., de la Chapelle, A. & Aaltonen, LA., Dec 1999, In : The American Journal of Pathology. 155, 6, p. 1849-1853 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  48. 2000
  49. Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer

    Järvinen, H. J., Aarnio, M., Mustonen, H., Aktan-Collan, K., Aaltonen, L. A., Peltomäki, P., de la Chapelle, A. & Mecklin, J. P., 2000, In : Gastroenterology. 118, p. 829-834 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  50. Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

    Hemminki, A., Mecklin, J. P., Jarvinen, H., Aaltonen, L. A. & Joensuu, H., 2000, In : Gastroenterology. 119, p. 921-928 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  51. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal cancer

    Roth, S., Johansson, M., Loukola, A., Peltomäki, P., Järvinen, H., Mecklin, J. P. & Aaltonen, L. A., 2000, In : Journal of Medical Genetics. 37, 4, p. 298-300 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  52. Paksusuolisyövälle altistavat geenivirheet ja niiden diagnostiikka

    Aaltonen, L. A. & Peltomäki, P. T., 2000, Gastroenterologia. K. H. M. F. E. K. P. P. (ed.). 2nd ed. Kustannus Oy Duodecim, p. 844-849

    Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

  53. No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas

    Launonen, T., Avizienyte, E., Loukola, A., Laiho, P., Salovaara, R., Jarvinen, H., Mecklin, JP., Oku, A., Shimane, M., Kim, HC., Kim, JC., Nezu, J. & Aaltonen, LA., 1 Feb 2000, In : Cancer Research. 60, 3, p. 546-548 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  54. Population-based molecular detection of hereditary nonpolyposis colorectal cancer

    Salovaara, R., Loukola, A., Kristo, P., Kaariainen, H., Ahtola, H., Eskelinen, M., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Jarvinen, H., Mecklin, JP., Aaltonen, LA. & de la Chapelle, A., Jun 2000, In : Journal of Clinical Oncology. 18, 11, p. 2193-2200 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  55. Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer

    Loukola, A., Vilkki, S., Singh, J., Launonen, T. & Aaltonen, LA., Aug 2000, In : The American Journal of Pathology. 157, 2, p. 347-352 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  56. The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI plus sporadic colorectal cancers

    Wheeler, JMD., Loukola, A., Aaltonen, LA., Mortensen, NJM. & Bodmer, WF., Aug 2000, In : Journal of Medical Genetics. 37, 8, p. 588-592 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  57. 2001
  58. Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC

    Lassus, H., Salovaara, R., Aaltonen, L. A. & Butzow, R., 2001, In : The American Journal of Pathology. 159, p. 35-42 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  59. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

    Zhou, X. P., Woodford-Richens, K., Lehtonen, R., Kurose, K., Aldred, M., Hampel, H., Launonen, V., Virta, S., Pilarski, R., Salovaara, R., Bodmer, W. F., Conrad, B. A., Dunlop, M., Hodgson, S. V., Iwama, T., Jarvinen, H., Kellokumpu, I., Kim, J. C., Leggett, B., Markie, D. & 9 othersMecklin, J. P., Neale, K., Phillips, R., Piris, J., Rozen, P., Houlston, R. S., Aaltonen, L. A., Tomlinson, I. P. M. & Eng, C., 2001, In : American Journal of Human Genetics. 69, p. 704-711 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  60. PPP2R1B gene in chronic lymphocytic leukemias and mantle cell lymphomas

    Zhu, Y., Loukola, A., Monni, O., Kuokkanen, K., Franssila, K., Elonen, E., Vilpo, J., Joensuu, H., Kere, J., Aaltonen, L. & Knuutila, S., 2001, In : Leukemia. 2001, 41, p. 177-183 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  61. p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: Further evidence of CHK2 in inherited cancer predisposition

    Vahteristo, P., Tamminen, A., Karvinen, P., Eerola, H., Eklund, C., Aaltonen, L. A., Blomqvist, C., Aittomäki, K. & Nevanlinna, H., 2001, In : Cancer Research. 61, p. 5718-5722 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  62. Comparison of serous and mucinous ovarian carcinomas: Distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4

    Lassus, H., Laitinen, M. P. E., Anttonen, M., Heikinheimo, M., Aaltonen, LA., Ritvos, O. & Butzow, R., Apr 2001, In : Laboratory Investigation. 81, 4, p. 517-526 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  63. Extensive somatic microsatellite mutations in normal human tissue

    Vilkki, S., Tsao, JL., Loukola, A., Poyhonen, P., Vierimaa, O., Herva, R., Aaltonen, LA. & Shibata, D., 1 Jun 2001, In : Cancer Research. 61, 11, p. 4541-4544 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  64. Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC)

    Loukola, A., Eklin, K., Laiho, P., Salovaara, R., Kristo, P., Jarvinen, H., Mecklin, JP., Launonen, T. & Aaltonen, LA., 1 Jun 2001, In : Cancer Research. 61, 11, p. 4545-4549 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  65. A germline E-cadherin mutation in a family with gastric and colon cancer

    Salahshor, S., Hou, H., Diep, CB., Loukola, A., Zhang, H., Liu, T., Chen, J., Iselius, L., Rubio, C., Lothe, RA., Aaltonen, L., Sun, XF., Lindmark, G. & Lindblom, A., Oct 2001, In : International Journal of Molecular Medicine. 8, 4, p. 439-443 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  66. 2002
  67. Few FH mutations in sporadic counterparts of tumor types observed in hereditary Leiomyomatosis and renal cell cancer families

    Kiuru, M., Lehtonen, R., Arola, J., Salovaara, R., Jarvinen, H., Aittomaki, K., Sjoberg, J., Visakorpi, T., Knuutila, S., Isola, J., Delahunt, B., Herva, R., Launonen, V., Karhu, A. & Aaltonen, L. A., 2002, In : Clinical Cancer Research. 62, p. 4554-4557 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  68. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

    Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S. & 12 othersLaiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V., Aaltonen, L. A. & Multiple Leiomyoma Consortium, 2002, In : Nature Genetics. 30, p. 406-410 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  69. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

    Rossi, D. J., Ylikorkala, A., Korsisaari, N., Salovaara, R., Luukko, K., Launonen, V., Henkemeyer, M., Ristimaki, A., Aaltonen, L. A. & Makela, T. P., 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, p. 12327-12332 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  70. No support for endoscopic surveillance for gastric cancer in hereditary non-polyposis colorectal cancer

    Renkonen-Sinisalo, L., Sipponen, P., Aarnio, M., Julkunen, R., Aaltonen, L. A., Sarna, S., Jarvinen, H. J. & Mecklin, J. P., 2002, In : Scandinavian Journal of Gastroenterology. 37, 5, p. 574-577 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  71. PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

    Zhou, X. P., Loukola, A., Salovaara, R., Nyström-Lahti, M., Peltomäki, P., de la Chapelle, A., Aaltonen, L. A. & Eng, C., 2002, In : The American Journal of Pathology. 161, 2, p. 439-447 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  72. Low-level microsatellite instability in most colorectal carcinomas

    Laiho, P., Launonen, T., Lahermo, P., Esteller, M., Guo, MZ., Herman, JG., Mecklin, JP., Jarvinen, H., Sistonen, P., Kim, KM., Shibata, D., Houlston, RS. & Aaltonen, LA., 15 Feb 2002, In : Cancer Research. 62, 4, p. 1166-1170 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  73. Frequent loss of SMAD4/DPC4 protein in colorectal cancers

    Salovaara, R., Roth, S., Loukola, A., Launonen, T., Sistonen, P., Avizienyte, E., Kristo, P., Jarvinen, H., Souchelnytskyi, S., Sarlomo-Rikala, M. & Aaltonen, LA., Jul 2002, In : Gut. 51, 1, p. 56-59 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  74. 2003
  75. Little evidence for involvement of MLH3 in colorectal cancer predisposition

    Hienonen, T., Laiho, P., Salovaara, R., Mecklin, J. P., Järvinen, H., Sistonen, P., Peltomäki, P., Lehtonen, R., Nupponen, N. N., Launonen, V., Karhu, A. & Aaltonen, L. A., 2003, In : International Journal of Cancer. 106, p. 292-296 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  76. Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients

    Enholm, S., Hienonen, T., Suomalainen, A., Lipton, L., Tomlinson, I., Karja, V., Eskelinen, M., Mecklin, J. P., Karhu, A., Jarvinen, H. J. & Aaltonen, L. A., 2003, In : The American Journal of Pathology. 163, p. 827-832 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  77. 2004
  78. BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing

    Domingo, E., Laiho, P., Ollikainen, M., Pinto, M., Wang, L., French, A. J., Westra, J., Frebourg, T., Espin, E., Armengol, M., Hamelin, R., Yamamoto, H., Hofstra, R. M. W., Seruca, R., Lindblom, A., Peltomäki, P., Thibodeau, S. N., Aaltonen, L. A. & Schwartz, S., 2004, In : Journal of Medical Genetics. 41, p. 664-668 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  79. Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors

    Lehtonen, R., Kiuru, M., Vanharanta, S., Sjöberg, J., Aaltonen, L. M., Aittomaki, K., Arola, J., Butzow, R., Eng, C., Husgafvel-Pursiainen, K., Isola, J., Jarvinen, H., Koivisto, P., Mecklin, J. P., Peltomäki, P., Salovaara, R., Wasenius, V. M., Karhu, A., Launonen, V., Nupponen, N. N. & 1 othersAaltonen, L. A., 2004, In : The American Journal of Pathology. 164, p. 17-22 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  80. Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status

    Oliveira, C., Westra, J. L., Arango, D., Ollikainen, M., Domingo, E., Ferreira, A., Velho, S., Niessen, R., Lagerstedt, K., Alhopuro, P., Laiho, P., Veiga, I., Teixeira, M. R., Ligtenberg, M., Kleibeuker, J. H., Sijmons, R. H., Plukker, J. T., Imai, K., Lage, P., Hamelin, R. & 8 othersAlbuquerque, C., Schwartz, S., Lindblom, A., Peltomäki, P., Yamamoto, H., Aaltonen, L. A., Seruca, R. & Hofstra, R. M. W., 2004, In : Human Molecular Genetics. 13, p. 2303-2311 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  81. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

    Vanharanta, S., Buchta, M., McWhinney, S. R., Virta, S. K., Peczkowska, M., Morrison, C. D., Lehtonen, R., Januszewicz, A., Jarvinen, H., Juhola, M., Mecklin, J. P., Pukkala, E., Herva, R., Kiuru, M., Nupponen, N. N., Aaltonen, L. A., Neumann, H. P. H. & Eng, C., 2004, In : American Journal of Human Genetics. 74, p. 153-159 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  82. 2005
  83. 7q deletion mapping and expression profiling in uterine fibroids

    Vanharanta, S., Wortham, N. C., Laiho, P., Sjöberg, J., Aittomäki, K., Arola, J., Tomlinson, I. P. M., Karhu, A., Arango, D. & Aaltonen, L. A., 2005, In : Oncogene. 24, 43, p. 6545-6554 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  84. A 17p11.2 germline deletion in a patient with Smith-Magenis syndrome and neuroblastoma

    Hienonen, T., Sammalkorpi, H., Isohanni, P., Versteeg, R., Karikoski, R. & Aaltonen, L. A., 2005, In : Journal of Medical Genetics. 42, 1, p. e3 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  85. A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis

    Alhopuro, P., Parker, A. R., Lehtonen, R., Enholm, S., Järvinen, H. J., Mecklin, J-P., Karhu, A., Eshleman, J. R. & Aaltonen, L. A., 2005, In : Human Mutation. 26, 4, p. 393 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  86. BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes

    Domingo, E., Niessen, R., Oliveira, C., Alhopuro, P., Moutinho, C., Espin, E., Armengol, M., Sijmons, R. H., Kleibeuker, J. H., Seruca, R., Aaltonen, L. A., Imai, K., Yamamoto, H., Schwartz, S. & Hofstra, R. M. W., 2005, In : Oncogene. 24, 24, p. 3995-3998 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  87. Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset

    Hampel, H., Stephens, J. A., Pukkala, E., Sankila, R., Aaltonen, L. A., Mecklin, J-P. & Chapelle, A. D. L., 2005, In : Gastroenterology. 129, 2, p. 415-421 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  88. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid

    Birkenkamp-Demtröder, K., Olesen, S. H., Sørensen, F. B., Laurberg, S., Laiho, P., Aaltonen, L. A. & Ørntoft, T. F., 2005, In : Gut. 54, 3, p. 374-384 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  89. Gene expression signatures for colorectal cancer microsatellite status and HNPCC

    Kruhøffer, M., Jensen, J. L., Laiho, P., Dyrskjot, L., Salovaara, R., Arango, D., Birkenkamp-Demtröder, K., Sørensen, F. B., Christensen, L. L., Buhl, L., Mecklin, J-P., Järvinen, H. J., Thykjaer, T., Wikman, F., Bech-Knudsen, F., Juhola, M., Nupponen, N., Laurberg, S., Andersen, C. L., Aaltonen, L. A. & 1 othersØrntoft, T. F., 2005, In : British Journal of Cancer. 92, 12, p. 2240-2248 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  90. Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer

    Arango, D., Laiho, P., Kokko, A., Alhopuro, P., Sammalkorpi, H., Salovaara, R., Nicorici, D., Hautaniemi, S., Alazzouzi, H., Mecklin, J-P., Järvinen, H. J., Hemminki, A. E., Astola, J., Schwartz, S. & Aaltonen, L. A., 2005, In : Gastroenterology. 129, 3, p. 874-884 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  91. Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors

    Alazzouzi, H., Davalos, V., Kokko, A., Domingo, E., Woerner, S. M., Wilson, A. J., Konrad, L., Laiho, P., Espin, E., Armengol, M., Imai, K., Yamamoto, H., Mariadason, J. M., Gebert, J. F., Aaltonen, L. A., Schwartz, S. & Arango, D., 2005, In : Cancer Research. 65, 22, p. 10170-10173 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  92. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis

    Sweet, K., Willis, J., Zhou, X-P., Gallione, C., Sawada, T., Alhopuro, P., Khoo, S. K., Patocs, A., Martin, C., Bridgeman, S., Heinz, J., Pilarski, R., Lehtonen, R., Prior, T. W., Frebourg, T., Teh, B. T., Marchuk, D. A., Aaltonen, L. A. & Eng, C., 2005, In : JAMA : The Journal of the American Medical Association. 294, 19, p. 2465-2473 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  93. Molecular staging for survival prediction of colorectal cancer patients

    Eschrich, S., Yang, I., Bloom, G., Kwong, K. Y., Boulware, D., Cantor, A., Coppola, D., Kruhøffer, M., Ørntoft, T. F., Quackenbush, J., Yeatman, T. J. & Aaltonen, L. A., 2005, In : Journal of Clinical Oncology. 23, 15, p. 3526-3535 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  94. Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD alpha, and MO25 alpha, in Peutz-Jeghers syndrome

    Alhopuro, P., Katajisto, P., Lehtonen, R., Ylisaukko-oja, S. K., Näätsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, p. 1126-1129 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  95. Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

    Alhopuro, P., Katajisto, P., Lehtonen, R. J., Ylisaukko-oja, S., Näätäsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P. M., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, 6, p. 1126-1129 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  96. Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers

    Hienonen, T., Sammalkorpi, H., Enholm, S., Alhopuro, P., Barber, T. D., Lehtonen, R., Nupponen, N. N., Lehtonen, H., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Koistinen, R., Arango, D., Launonen, V., Vogelstein, B., Karhu, A. & Aaltonen, L. A., 2005, In : Cancer Research. 65, 11, p. 4607-4613 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  97. No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer

    Vahteristo, P., Ojala, S., Tamminen, A., Tommiska, J., Sammalkorpi, H., Kiuru-Kuhlefelt, S., Eerola, H., Aaltonen, L. A., Aittomäki, K. & Nevanlinna, H., 2005, In : Journal of Medical Genetics. 42, 4, p. e22 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  98. No germline FH mutations in familial breast cancer patients

    Kiuru, M. H. T., Lehtonen, R., Eerola, H., Aittomäki, K., Blomqvist, C., Nevanlinna, H., Aaltonen, L. A. & Launonen, V., 2005, In : European Journal of Human Genetics. 13, 4, p. 506-509 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  99. Numbers of mutations to different types of colorectal cancer

    Calabrese, P., Mecklin, J-P., Järvinen, H. J., Aaltonen, L. A., Tavare, S. & Shibata, D., 2005, In : BMC Cancer. 5, 126, 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  100. SMAD4 as a prognostic marker in colorectal cancer

    Alazzouzi, H., Alhopuro, P., Salovaara, R., Sammalkorpi, H., Järvinen, H. J., Mecklin, J-P., Hemminki, A., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 7, p. 2606-2611 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  101. SMAD4 levels and response to 5-fluorouracil in colorectal cancer

    Alhopuro, P., Alazzouzi, H., Sammalkorpi, H., Davalos, V., Salovaara, R., Hemminki, A., Järvinen, H. J., Mecklin, J-P., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 17, p. 6311-6316 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  102. The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population

    Rasinpera, H., Forsblom, C., Enattah, N. S., Halonen, P., Salo, K., Victorzon, M., Mecklin, J. P., Jarvinen, H., Enholm, S., Sellick, G., Alazzouzi, H., Houlston, R., Robinson, J., Groop, P. H., Tomlinson, I., Schwartz, S., Aaltonen, L. A., Jarvela, I. & FinnDiane Study Grp, 2005, In : Gut. 54, p. 643-647 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  103. The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck

    Alhopuro, P., Ylisaukko-oja, S., Koskinen, W., Bono, P., Arola, J., Järvinen, H. J., Mecklin, J-P., Atula, T., Kontio, R., Mäkitie, A., Suominen, S., Leivo, I., Vahteristo, P., Aaltonen, L-M., Aaltonen, L. A. & Suominen, S., 2005, In : Journal of Medical Genetics. 42, 9, p. 694-698 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  104. p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome

    Sotamaa, K., Liyanarachchi, S., Mecklin, J-P., Järvinen, H. J., Aaltonen, L. A., Peltomäki, P. & Chapelle, A. D. L., 2005, In : Clinical Cancer Research. 11, 19, p. 6840-6844 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  105. 2006
  106. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

    Ropero, S., Fraga, M. F., Ballestar, E., Hamelin, R., Yamamoto, H., Boix-Chornet, M., Caballero, R., Alaminos, M., Setien, F., Paz, M. F., Herranz, M., Palacios, J., Arango, D., Ørntoft, T. F., Aaltonen, L. A., Schwartz, S. & Esteller, M., 2006, In : Nature Genetics. 38, 5, p. 566-569 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  107. AIP-mutaatiot altistavat aivolisäkkeen adenomalle: [referaatti Science lehden artikkelista]

    Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., de Menis, E., Mäkinen, M. J., Launonen, V., Aaltonen, L. A. & Karhu, A., 2006, In : Duodecim. 122, 12, p. 1419-1420 2 p.

    Research output: Contribution to journalArticleScientific

  108. Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients

    Ylisaukko-oja, S., Kiuru, M., Lehtonen, H. J., Lehtonen, R., Pukkala, E., Arola, J., Launonen, V. & Aaltonen, L. A., 2006, In : International Journal of Cancer. 119, 2, p. 283-287 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  109. CHEK2 I157T associates with familial and sporadic colorectal cancer: [electronic letter]

    Kilpivaara, O., Alhopuro, P., Vahteristo, P., Aaltonen, L. A. & Nevanlinna, H., 2006, In : Journal of Medical Genetics. 43, p. e34

    Research output: Contribution to journalArticleScientificpeer-review

  110. Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

    Vanharanta, S., Pollard, P. J., Lehtonen, H. J., Laiho, P., Sjöberg, J., Leminen, A., Aittomäki, K., Arola, J., Kruhøffer, M., Ørntoft, T. F., Tomlinson, I. P., Kiuru, M., Arango, D. & Aaltonen, L. A., 2006, In : Human Molecular Genetics. 15, 1, p. 97-103 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  111. EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

    Kokko, A., Laiho, P., Lehtonen, R., Korja, S., Carvajal-Carmona, L., Järvinen, H. J., Mecklin, J-P., Eng, C., Schleutker, J., Tomlinson, I. P. M., Vahteristo, P. & Aaltonen, L. A., 2006, In : BMC Cancer. 6, 145, 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  112. EPHB4 and survival of colorectal cancer patients

    Davalos, V., Dopeso, H., Castano, J., Wilson, A. J., Vilardell, F., Romero-Gimenez, J., Espin, E., Armengol, M., Capella, G., Mariadason, J. M., Aaltonen, L. A., Schwartz, S. & Arango, D., 2006, In : Cancer Research. 66, 18, p. 8943-8948 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  113. Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma

    Ylisaukko-oja, S. K., Cybulski, C., Lehtonen, R., Kiuru, M., Matyjasik, J., Szymanska, A., Szymanska-Pasternak, J., Dyrskjot, L., Butzow, R., Orntoft, T. F., Launonen, V., Lubinski, J. & Aaltonen, L. A., 2006, In : European Journal of Human Genetics. 14, 7, p. 880-883 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  114. In response: SMAD4 levels and allelic imbalance in 18q21 in colorectal cancer

    Arango, D., Alhopuro, P. & Aaltonen, L. A., 2006, In : Clinical Cancer Research. 12, 5, p. 1654-1655 2 p.

    Research output: Contribution to journalArticleScientific

  115. Increased risk of cancer in patients with fumarate hydratase germline mutation

    Lehtonen, H., Kiuru, M., Ylisaukko-oja, S., Salovaara, R., Herva, R., Koivisto, P., Vierimaa, O., Aittomäki, K., Pukkala, E., Launonen, V., Aaltonen, L. A. & Lehtonen, H., 2006, In : Journal of Medical Genetics. 43, 6, p. 523-526 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

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