Lauri Aaltonen

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  1. 1992
  2. EVIDENCE THAT THE MCC-APC GENE REGION IN 5Q21 IS NOT THE SITE FOR SUSCEPTIBILITY TO HEREDITARY NONPOLYPOSIS COLORECTAL-CARCINOMA

    PELTOMAKI, P., SISTONEN, P., MECKLIN, J. P., PYLKKANEN, L., AALTONEN, L., NORDLING, S., KERE, J., JARVINEN, H., HAMILTON, S. R., PETERSEN, G., KINZLER, K. W., VOGELSTEIN, B. & DELACHAPELLE, A., 1992, In : Cancer Research. 1992, 52, p. 4530-4533 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  3. 1993
  4. Clues to the pathogenesis of familial colorectal cancer

    AALTONEN, L. A., Peltomäki, P., LEACH, F. S., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., Järvinen, H., POWELL, S. M., JEN, J., HAMILTON, S. R., PETERSEN, G. M., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1993, In : Science. 260, p. 812-816 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  5. Genetic mapping of a locus predisposing to human colorectal cancer

    Peltomäki, P., AALTONEN, L. A., SISTONEN, P., PYLKKANEN, L., MECKLIN, J. P., JARVINEN, H., GREEN, J. S., JASS, J. R., WEBER, J. L., LEACH, F. S., PETERSEN, G. M., HAMILTON, S. R., DELACHAPELLE, A. & VOGELSTEIN, B., 1993, In : Science. 260, p. 810-812 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  6. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history

    LOTHE, R. A., Peltomäki, P., MELING, G. I., AALTONEN, L. A., NYSTROMLAHTI, M., PYLKKANEN, L., HEIMDAL, K., ANDERSEN, T. I., MOLLER, P., ROGNUM, T. O., FOSSA, S. D., HALDORSEN, T., LANGMARK, F., BROGGER, A., DELACHAPELLE, A. & BORRESEN, A. L., 1993, In : Cancer Research. 53, p. 5849-5852 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  7. Läpimurto paksusuolisyövän geneettisen taustan selvittämisessä

    Peltomäki, P. T., Aaltonen, L. A., Mecklin, JP. & de la Chapelle, A., 1993, In : Duodecim. 109, p. 1367-1369

    Research output: Contribution to journalReview ArticleScientificpeer-review

  8. Microsatellite instability is associated with tumors that characterize the hereditary nonpolyposis colorectal carcinoma syndrome

    Peltomäki, P., LOTHE, R. A., AALTONEN, L. A., PYLKKANEN, L., Nyström-Lahti, M., SERUCA, R., DAVID, L., HOLM, R., RYBERG, D., HAUGEN, A., BROGGER, A., BORRESEN, A. L. & de la Chapelle, A., 1993, In : Cancer Research. 53, p. 5853-5855 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  9. Mutations of a MutS homolog in hereditary non-polyposis colorectal cancer

    LEACH, F. S., NICOLAIDES, N. C., PAPADOPOULOS, N., LIU, B., JEN, J., PARSONS, R., Peltomäki, P., SISTONEN, P., Aaltonen, L. A., NYSTROMLAHTI, M., GUAN, X. Y., ZHANG, J., MELTZER, P. S., YU, J. W., KAO, F. T., CHEN, D. J., CEROSALETTI, K. M., FOURNIER, R. E. K., TODD, S., LEWIS, T. & 15 othersLEACH, R. J., NAYLOR, S. L., WEISSENBACH, J., MECKLIN, J. P., Järvinen, H., PETERSEN, G. M., HAMILTON, S. R., GREEN, J., JASS, J., WATSON, P., LYNCH, H. T., TRENT, J. M., de la Chapelle, A., KINZLER, K. W. & VOGELSTEIN, B., 1993, In : Cell. 75, p. 1215-1225 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  10. 1994
  11. A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancel burden

    Aaltonen, L. A., SANKILA, R., MECKLIN, J. P., Järvinen, H., PUKKALA, E., Peltomäki, P. & de la Chapelle, A., 1994, In : Cancer Detection and Prevention. 18, p. 57-63 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  12. Close linkage to chromosome 3p and conservation of ancestral founding haplotype in hereditary nonpolyposis colorectal cancer families

    Nyström-Lahti, M., Sistonen, P., Mecklin, J. P., Pylkkänen, L., Aaltonen, L. A., Järvinen, H., Weissenbach, J., de la Chapelle, A. & Peltomäki, P., 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, p. 6054-6058 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  13. Genes involved in hereditary nonpolyposis colorectal carcinoma

    Aaltonen, L. A. & Peltomäki, P. T., 1994, In : Anticancer Research. 14, p. 1657-1660

    Research output: Contribution to journalReview ArticleScientificpeer-review

  14. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

    Hemminki, A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., Salovaara, R., Nyström-Lahti, M., de la Chapelle, A. & Aaltonen, L. A., 1994, In : Nature Genetics. 8, p. 405-410 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  15. Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage

    Nyström-Lahti, M., PARSONS, R., SISTONEN, P., Pylkkänen, L., Aaltonen, L. A., LEACH, F. S., HAMILTON, S. R., WATSON, P., BRONSON, E., CAVALIERI, J., LYNCH, J., LANSPA, S., SMYRK, T., LYNCH, P., DROUHARD, T., KINZLER, K. W., VOGELSTEIN, B., LYNCH, H. T., de la Chapelle, A. & Peltomäki, P., 1994, In : American Journal of Human Genetics. 55, p. 659-665 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  16. Replication errors in benign and malignant tumors from hederitary nonpolyposis colorectal cancer patients

    Aaltonen, L. A., Peltomäki, P., MECKLIN, J. P., Järvinen, H., JASS, J. R., GREEN, J. S., LYNCH, H. T., WATSON, P., TALLQVIST, G., JUHOLA, M., SISTONEN, P., HAMILTON, S. R., KINZLER, K. W., VOGELSTEIN, B. & de la Chapelle, A., 1994, In : Cancer Research. 54, p. 1645-1648 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  17. 1995
  18. Founding mutations and Alu-mediated recombination in hereditary colon cancer

    Nyström-Lahti, M., KRISTO, P., NICOLAIDES, N. C., CHANG, S. Y., Aaltonen, L. A., MOISIO, A. L., Järvinen, H. J., MECKLIN, J. P., KINZLER, K. W., VOGELSTEIN, B., de la Chapelle, A. & Peltomäki, P., 1995, In : Nature Medicine. 1, 11, p. 1203-1206 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  19. Periytyvä syöpä

    Mecklin, J-P., Peltomäki, P. T., Aaltonen, L. A. & Kääriäinen, H., 1995, In : Suomen lääkärilehti. 50, 18-19, p. 2057-2064

    Research output: Contribution to journalReview ArticleScientificpeer-review

  20. 1996
  21. No evidence of microsatellite instability in bone tumors

    Tarkkanen, M., Aaltonen, L. A., Böhling, T. O., Kivioja, A. H., Karaharju, E., Elomaa, A. I. & Knuutila, Y. S., 1996, In : British Journal of Cancer. 74, p. 453-455

    Research output: Contribution to journalArticleScientificpeer-review

  22. Semiautomated assessment of loss of heterozygosity and replication error in tumors

    Canzian, F., Salovaara, R., Hemminki, A., Kristo, P., Chadwick, R. B., Aaltonen, L. A. & delaChapelle, A., 1996, In : Cancer Research. 56, p. 3331-3337 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  23. Somatic microsatellite mutations as molecular tumor clocks

    Shibata, D., Navidi, W., Salovaara, R., Li, Z. H. & Aaltonen, L. A., 1996, In : Nature Medicine. 2, p. 676-681 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  24. 1997
  25. Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome

    Marsh, D. J., Roth, S., Lunetta, K. L., Hemminki, A., Dahia, P. L. M., Sistonen, P., Zheng, Z. M., Caron, S., vanOrsouw, N. J., Bodmer, W. F., Cottrell, S. E., Dunlop, M. G., Eccles, D., Hodgson, S. V., Jarvinen, H., Kellokumpu, I., Markie, D., Neale, K., Phillips, R., Rozen, P. & 5 othersSyngal, S., Vijg, J., Tomlinson, I. P. M., Aaltonen, L. A. & Eng, C., 1997, In : Cancer Research. 57, p. 5017-5021 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  26. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

    Hemminki, A., Tomlinson, I., Markie, D., Jarvinen, H., Sistonen, P., Bjorkqvist, A. M., Knuutila, S., Salovaara, R., Bodmer, W., Shibata, D., delaChapelle, A. & Aaltonen, L. A., 1997, In : Nature Genetics. 15, p. 87-90 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  27. MSH2 and MLH1 mutations in sporadic replication error-positive colorectal carcinoma as assessed by two-dimensional DNA electrophoresis

    Wu, Y., Nyström-Lahti, M., Osinga, J., Looman, M. W. G., Peltomäki, P., Aaltonen, L. A., de la Chapelle, A., Hofstra, R. M. W. & Buys, C. H. C. M., 1997, In : Genes, Chromosomes & Cancer. 18, p. 269-278 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  28. 1998
  29. A missense mutation in the BRCA2 gene in three siblings with ovarian cancer

    Roth, S., Kristo, P., Auranen, A., Shayeghi, M., Seal, S., Collins, N., Barfoot, R., Rahman, N., Klemi, P. J., Grenman, S., Sarantaus, L., Nevanlinna, H., Butzow, R., Ashworth, A., Stratton, M. R. & Aaltonen, L. A., 1998, In : British Journal of Cancer. 77, p. 1199-1202 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  30. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease

    Aaltonen, L. A., Salovaara, R., Kristo, P., Canzian, F., Hemminki, A., Peltomäki, P., Chadwick, R. B., Kääriäinen, H., Eskelinen, M., Jarvinen, H., Mecklin, J. P., de la Chapelle, A., Percesepe, A., Ahtola, H., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J. & ValKamo, E., 1998, In : New England Journal of Medicine. 338, 21, p. 1481-1487 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  31. Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene

    Hemminki, A., Hoglund, P., Pukkala, E., Salovaara, R., Jarvinen, H., Norio, R. & Aaltonen, L. A., 1998, In : Oncogene. 16, p. 681-684 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  32. Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability

    Percesepe, A., Kristo, P., Aaltonen, L. A., de Leon, M. P., de la Chapelle, A. & Peltomäki, P., 1998, In : Oncogene. 17, p. 157-163 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  33. Mutations in the SMAD4/DPC4 gene in juvenile polyposis

    Howe, J. R., Roth, S., Ringold, J. C., Summers, R. W., Jarvinen, H. J., Sistonen, P., Tomlinson, I. P. M., Houlston, R. S., Bevan, S., Mitros, F. A., Stone, E. M. & Aaltonen, L. A., 1998, In : Informing Science. 280, p. 1086-1088 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  34. Periytyvän paksusuolisyövän yleisyys ja molekyyligeneettinen seulonta Suomessa

    Aaltonen, L. A., Salovaara, R., Krio, P., Canzian, F., Hemminki, A., Percesepe, A., Peltomäki, P. T., de la Chapelle, A., Chadwick, R. B., Kääriäinen, H., Ahtola, H., Eskelinen, M., Härkönen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Järvinen, H. & Mecklin, J-P., 1998, In : Duodecim. 114, p. 2084-2085

    Research output: Contribution to journalReview ArticleScientificpeer-review

  35. Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3

    Olschwang, S., Markie, D., Seal, S., Neale, K., Phillips, R., Cottrell, S., Ellis, I., Hodgson, S., Zauber, P., Spigelman, A., Iwama, T., Loff, S., McKeown, C., Marchese, C., Sampson, J., Davies, S., Talbot, I., Wyke, J., Thomas, G., Bodmer, W. & 7 othersHemminki, A., Avizienyte, E., de la Chapelle, A., Aaltonen, L., Stratton, M., Houlston, R. & Tomlinson, I., 1998, In : Journal of Medical Genetics. 35, p. 42-44 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  36. Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors

    Avizienyte, E., Roth, S., Loukola, A., Hemminki, A., Lothe, R. A., Stenwig, A. E., Fossa, S. D., Salovaara, R. & Aaltonen, L. A., 1998, In : Cancer Research. 58, p. 2087-2090 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  37. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

    Hemminki, A., Markie, D., Tomlinson, S. J., Avizienyte, E., Roth, S., Loukola, A., Bignell, G., Warren, W., Aminoff, M., Höglund, P., Jarvinen, H., Kristo, P., Pelin, K., Ridanpaa, M., Salovaara, R., Toro, T., Bodmer, W., Olschwang, S., Olsen, AS., Stratton, MR. & 2 othersde la Chapelle, A. & Aaltonen, LA., 8 Jan 1998, In : Nature. 391, 6663, p. 184-187 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  38. 1999
  39. Cancer risk in mutation carriers of DNA-mismatch-repair genes

    Aarnio, M., Sankila, R., Pukkala, E., Salovaara, R., Aaltonen, L. A., de la Chapelle, A., Peltomäki, P., Mecklin, J. P. & Jarvinen, H. J., 1999, In : International Journal of Cancer. 81, p. 214-218 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  40. Epigenetic phenotypes distinguish microsatellite stable and unstable colorectal cancers

    Kuismanen, S. A., Holmberg, M. T., Salovaara, R., Schweizer, P., Aaltonen, L. A., de la Chapelle, A., Nyström-Lahti, M. & Peltomäki, P., 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, p. 12661-12666 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  41. LKB1 somatic mutations in sporadic tumors

    Avizienyte, E., Loukola, A., Roth, S., Hemminki, A., Tarkkanen, M., Salovaara, R., Arola, J., Butzow, R., Husgafvel-Pursiainen, K., Kokkola, A., Jarvinen, H. & Aaltonen, L. A., 1999, In : The American Journal of Pathology. 154, 3, p. 677-681 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  42. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer

    Ylikorkala, A., Avizienyte, E., Tomlinson, I. P. M., Tiainen, M., Roth, S., Loukola, A., Hemminki, A., Johansson, M., Sistonen, P., Markie, D., Neale, K., Phillips, R., Zauber, P., Twama, T., Sampson, J., Järvinen, H., Makela, T. P. & Aaltonen, L. A., 1999, In : Human Molecular Genetics. 8, p. 45-51 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  43. SMAD genes in juvenile polyposis

    Roth, S., Sistonen, P., Salovaara, R., Hemminki, A., Loukola, A., Johansson, M., Avizienyte, E., Cleary, K. A., Lynch, P., Amos, C. I., Kristo, P., Mecklin, J. P., Kellokumpu, I., Jarvinen, H. & Aaltonen, L. A., 1999, In : Genes, Chromosomes & Cancer. 26, 1, p. 54-61 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  44. The I1307K polymorphism of the APC gene in colorectal cancer

    Prior, TW., Chadwick, RB., Papp, AC., Arcot, AN., Isa, AM., Pearl, DK., Stemmermann, G., Percesepe, A., Loukola, A., Aaltonen, LA. & de la Chapelle, A., Jan 1999, In : Gastroenterology. 116, 1, p. 58-63 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  45. Strategies for screening for hereditary non-polyposis colorectal cancer

    Loukola, A., de la Chapelle, A. & Aaltonen, LA., Nov 1999, In : Journal of Medical Genetics. 36, 11, p. 819-822 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  46. The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

    Riccio, A., Aaltonen, LA., Godwin, AK., Loukola, A., Percesepe, A., Salovaara, R., Masciullo, T., Genuardi, M., Paravatou-Petsotas, M., Bassi, DE., Ruggeri, BA., Klein-Szanto, AJP., Testa, T., Neri, G. & Bellacosa, A., Nov 1999, In : Nature Genetics. 23, 3, p. 266-268 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  47. Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer

    Loukola, A., Salovaara, R., Kristo, P., Moisio, AL., Kaariainen, H., Ahtola, H., Eskelinen, M., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Jarvinen, H., Mecklin, JP., de la Chapelle, A. & Aaltonen, LA., Dec 1999, In : The American Journal of Pathology. 155, 6, p. 1849-1853 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  48. 2000
  49. Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer

    Järvinen, H. J., Aarnio, M., Mustonen, H., Aktan-Collan, K., Aaltonen, L. A., Peltomäki, P., de la Chapelle, A. & Mecklin, J. P., 2000, In : Gastroenterology. 118, p. 829-834 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  50. Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

    Hemminki, A., Mecklin, J. P., Jarvinen, H., Aaltonen, L. A. & Joensuu, H., 2000, In : Gastroenterology. 119, p. 921-928 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  51. Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal cancer

    Roth, S., Johansson, M., Loukola, A., Peltomäki, P., Järvinen, H., Mecklin, J. P. & Aaltonen, L. A., 2000, In : Journal of Medical Genetics. 37, 4, p. 298-300 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  52. Paksusuolisyövälle altistavat geenivirheet ja niiden diagnostiikka

    Aaltonen, L. A. & Peltomäki, P. T., 2000, Gastroenterologia. K. H. M. F. E. K. P. P. (ed.). 2nd ed. Kustannus Oy Duodecim, p. 844-849

    Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

  53. No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas

    Launonen, T., Avizienyte, E., Loukola, A., Laiho, P., Salovaara, R., Jarvinen, H., Mecklin, JP., Oku, A., Shimane, M., Kim, HC., Kim, JC., Nezu, J. & Aaltonen, LA., 1 Feb 2000, In : Cancer Research. 60, 3, p. 546-548 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  54. Population-based molecular detection of hereditary nonpolyposis colorectal cancer

    Salovaara, R., Loukola, A., Kristo, P., Kaariainen, H., Ahtola, H., Eskelinen, M., Harkonen, N., Julkunen, R., Kangas, E., Ojala, S., Tulikoura, J., Valkamo, E., Jarvinen, H., Mecklin, JP., Aaltonen, LA. & de la Chapelle, A., Jun 2000, In : Journal of Clinical Oncology. 18, 11, p. 2193-2200 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  55. Germline and somatic mutation analysis of MLH3 in MSI-positive colorectal cancer

    Loukola, A., Vilkki, S., Singh, J., Launonen, T. & Aaltonen, LA., Aug 2000, In : The American Journal of Pathology. 157, 2, p. 347-352 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  56. The role of hypermethylation of the hMLH1 promoter region in HNPCC versus MSI plus sporadic colorectal cancers

    Wheeler, JMD., Loukola, A., Aaltonen, LA., Mortensen, NJM. & Bodmer, WF., Aug 2000, In : Journal of Medical Genetics. 37, 8, p. 588-592 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  57. 2001
  58. Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC

    Lassus, H., Salovaara, R., Aaltonen, L. A. & Butzow, R., 2001, In : The American Journal of Pathology. 159, p. 35-42 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  59. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

    Zhou, X. P., Woodford-Richens, K., Lehtonen, R., Kurose, K., Aldred, M., Hampel, H., Launonen, V., Virta, S., Pilarski, R., Salovaara, R., Bodmer, W. F., Conrad, B. A., Dunlop, M., Hodgson, S. V., Iwama, T., Jarvinen, H., Kellokumpu, I., Kim, J. C., Leggett, B., Markie, D. & 9 othersMecklin, J. P., Neale, K., Phillips, R., Piris, J., Rozen, P., Houlston, R. S., Aaltonen, L. A., Tomlinson, I. P. M. & Eng, C., 2001, In : American Journal of Human Genetics. 69, p. 704-711 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  60. PPP2R1B gene in chronic lymphocytic leukemias and mantle cell lymphomas

    Zhu, Y., Loukola, A., Monni, O., Kuokkanen, K., Franssila, K., Elonen, E., Vilpo, J., Joensuu, H., Kere, J., Aaltonen, L. & Knuutila, S., 2001, In : Leukemia. 2001, 41, p. 177-183 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  61. p53, CHK2, and CHK1 genes in Finnish families with Li-Fraumeni syndrome: Further evidence of CHK2 in inherited cancer predisposition

    Vahteristo, P., Tamminen, A., Karvinen, P., Eerola, H., Eklund, C., Aaltonen, L. A., Blomqvist, C., Aittomäki, K. & Nevanlinna, H., 2001, In : Cancer Research. 61, p. 5718-5722 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  62. Comparison of serous and mucinous ovarian carcinomas: Distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4

    Lassus, H., Laitinen, M. P. E., Anttonen, M., Heikinheimo, M., Aaltonen, LA., Ritvos, O. & Butzow, R., Apr 2001, In : Laboratory Investigation. 81, 4, p. 517-526 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  63. Extensive somatic microsatellite mutations in normal human tissue

    Vilkki, S., Tsao, JL., Loukola, A., Poyhonen, P., Vierimaa, O., Herva, R., Aaltonen, LA. & Shibata, D., 1 Jun 2001, In : Cancer Research. 61, 11, p. 4541-4544 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  64. Microsatellite marker analysis in screening for hereditary nonpolyposis colorectal cancer (HNPCC)

    Loukola, A., Eklin, K., Laiho, P., Salovaara, R., Kristo, P., Jarvinen, H., Mecklin, JP., Launonen, T. & Aaltonen, LA., 1 Jun 2001, In : Cancer Research. 61, 11, p. 4545-4549 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  65. A germline E-cadherin mutation in a family with gastric and colon cancer

    Salahshor, S., Hou, H., Diep, CB., Loukola, A., Zhang, H., Liu, T., Chen, J., Iselius, L., Rubio, C., Lothe, RA., Aaltonen, L., Sun, XF., Lindmark, G. & Lindblom, A., Oct 2001, In : International Journal of Molecular Medicine. 8, 4, p. 439-443 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  66. 2002
  67. Few FH mutations in sporadic counterparts of tumor types observed in hereditary Leiomyomatosis and renal cell cancer families

    Kiuru, M., Lehtonen, R., Arola, J., Salovaara, R., Jarvinen, H., Aittomaki, K., Sjoberg, J., Visakorpi, T., Knuutila, S., Isola, J., Delahunt, B., Herva, R., Launonen, V., Karhu, A. & Aaltonen, L. A., 2002, In : Clinical Cancer Research. 62, p. 4554-4557 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  68. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

    Tomlinson, I. P. M., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E. M., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S. & 12 othersLaiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V., Aaltonen, L. A. & Multiple Leiomyoma Consortium, 2002, In : Nature Genetics. 30, p. 406-410 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  69. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

    Rossi, D. J., Ylikorkala, A., Korsisaari, N., Salovaara, R., Luukko, K., Launonen, V., Henkemeyer, M., Ristimaki, A., Aaltonen, L. A. & Makela, T. P., 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, p. 12327-12332 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  70. No support for endoscopic surveillance for gastric cancer in hereditary non-polyposis colorectal cancer

    Renkonen-Sinisalo, L., Sipponen, P., Aarnio, M., Julkunen, R., Aaltonen, L. A., Sarna, S., Jarvinen, H. J. & Mecklin, J. P., 2002, In : Scandinavian Journal of Gastroenterology. 37, 5, p. 574-577 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  71. PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers

    Zhou, X. P., Loukola, A., Salovaara, R., Nyström-Lahti, M., Peltomäki, P., de la Chapelle, A., Aaltonen, L. A. & Eng, C., 2002, In : The American Journal of Pathology. 161, 2, p. 439-447 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  72. Low-level microsatellite instability in most colorectal carcinomas

    Laiho, P., Launonen, T., Lahermo, P., Esteller, M., Guo, MZ., Herman, JG., Mecklin, JP., Jarvinen, H., Sistonen, P., Kim, KM., Shibata, D., Houlston, RS. & Aaltonen, LA., 15 Feb 2002, In : Cancer Research. 62, 4, p. 1166-1170 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  73. Frequent loss of SMAD4/DPC4 protein in colorectal cancers

    Salovaara, R., Roth, S., Loukola, A., Launonen, T., Sistonen, P., Avizienyte, E., Kristo, P., Jarvinen, H., Souchelnytskyi, S., Sarlomo-Rikala, M. & Aaltonen, LA., Jul 2002, In : Gut. 51, 1, p. 56-59 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  74. 2003
  75. Little evidence for involvement of MLH3 in colorectal cancer predisposition

    Hienonen, T., Laiho, P., Salovaara, R., Mecklin, J. P., Järvinen, H., Sistonen, P., Peltomäki, P., Lehtonen, R., Nupponen, N. N., Launonen, V., Karhu, A. & Aaltonen, L. A., 2003, In : International Journal of Cancer. 106, p. 292-296 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  76. Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients

    Enholm, S., Hienonen, T., Suomalainen, A., Lipton, L., Tomlinson, I., Karja, V., Eskelinen, M., Mecklin, J. P., Karhu, A., Jarvinen, H. J. & Aaltonen, L. A., 2003, In : The American Journal of Pathology. 163, p. 827-832 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  77. 2004
  78. BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing

    Domingo, E., Laiho, P., Ollikainen, M., Pinto, M., Wang, L., French, A. J., Westra, J., Frebourg, T., Espin, E., Armengol, M., Hamelin, R., Yamamoto, H., Hofstra, R. M. W., Seruca, R., Lindblom, A., Peltomäki, P., Thibodeau, S. N., Aaltonen, L. A. & Schwartz, S., 2004, In : Journal of Medical Genetics. 41, p. 664-668 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  79. Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors

    Lehtonen, R., Kiuru, M., Vanharanta, S., Sjöberg, J., Aaltonen, L. M., Aittomaki, K., Arola, J., Butzow, R., Eng, C., Husgafvel-Pursiainen, K., Isola, J., Jarvinen, H., Koivisto, P., Mecklin, J. P., Peltomäki, P., Salovaara, R., Wasenius, V. M., Karhu, A., Launonen, V., Nupponen, N. N. & 1 othersAaltonen, L. A., 2004, In : The American Journal of Pathology. 164, p. 17-22 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  80. Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status

    Oliveira, C., Westra, J. L., Arango, D., Ollikainen, M., Domingo, E., Ferreira, A., Velho, S., Niessen, R., Lagerstedt, K., Alhopuro, P., Laiho, P., Veiga, I., Teixeira, M. R., Ligtenberg, M., Kleibeuker, J. H., Sijmons, R. H., Plukker, J. T., Imai, K., Lage, P., Hamelin, R. & 8 othersAlbuquerque, C., Schwartz, S., Lindblom, A., Peltomäki, P., Yamamoto, H., Aaltonen, L. A., Seruca, R. & Hofstra, R. M. W., 2004, In : Human Molecular Genetics. 13, p. 2303-2311 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  81. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

    Vanharanta, S., Buchta, M., McWhinney, S. R., Virta, S. K., Peczkowska, M., Morrison, C. D., Lehtonen, R., Januszewicz, A., Jarvinen, H., Juhola, M., Mecklin, J. P., Pukkala, E., Herva, R., Kiuru, M., Nupponen, N. N., Aaltonen, L. A., Neumann, H. P. H. & Eng, C., 2004, In : American Journal of Human Genetics. 74, p. 153-159 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  82. 2005
  83. 7q deletion mapping and expression profiling in uterine fibroids

    Vanharanta, S., Wortham, N. C., Laiho, P., Sjöberg, J., Aittomäki, K., Arola, J., Tomlinson, I. P. M., Karhu, A., Arango, D. & Aaltonen, L. A., 2005, In : Oncogene. 24, 43, p. 6545-6554 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  84. A 17p11.2 germline deletion in a patient with Smith-Magenis syndrome and neuroblastoma

    Hienonen, T., Sammalkorpi, H., Isohanni, P., Versteeg, R., Karikoski, R. & Aaltonen, L. A., 2005, In : Journal of Medical Genetics. 42, 1, p. e3 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  85. A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis

    Alhopuro, P., Parker, A. R., Lehtonen, R., Enholm, S., Järvinen, H. J., Mecklin, J-P., Karhu, A., Eshleman, J. R. & Aaltonen, L. A., 2005, In : Human Mutation. 26, 4, p. 393 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  86. BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes

    Domingo, E., Niessen, R., Oliveira, C., Alhopuro, P., Moutinho, C., Espin, E., Armengol, M., Sijmons, R. H., Kleibeuker, J. H., Seruca, R., Aaltonen, L. A., Imai, K., Yamamoto, H., Schwartz, S. & Hofstra, R. M. W., 2005, In : Oncogene. 24, 24, p. 3995-3998 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  87. Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset

    Hampel, H., Stephens, J. A., Pukkala, E., Sankila, R., Aaltonen, L. A., Mecklin, J-P. & Chapelle, A. D. L., 2005, In : Gastroenterology. 129, 2, p. 415-421 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  88. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid

    Birkenkamp-Demtröder, K., Olesen, S. H., Sørensen, F. B., Laurberg, S., Laiho, P., Aaltonen, L. A. & Ørntoft, T. F., 2005, In : Gut. 54, 3, p. 374-384 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  89. Gene expression signatures for colorectal cancer microsatellite status and HNPCC

    Kruhøffer, M., Jensen, J. L., Laiho, P., Dyrskjot, L., Salovaara, R., Arango, D., Birkenkamp-Demtröder, K., Sørensen, F. B., Christensen, L. L., Buhl, L., Mecklin, J-P., Järvinen, H. J., Thykjaer, T., Wikman, F., Bech-Knudsen, F., Juhola, M., Nupponen, N., Laurberg, S., Andersen, C. L., Aaltonen, L. A. & 1 othersØrntoft, T. F., 2005, In : British Journal of Cancer. 92, 12, p. 2240-2248 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  90. Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer

    Arango, D., Laiho, P., Kokko, A., Alhopuro, P., Sammalkorpi, H., Salovaara, R., Nicorici, D., Hautaniemi, S., Alazzouzi, H., Mecklin, J-P., Järvinen, H. J., Hemminki, A. E., Astola, J., Schwartz, S. & Aaltonen, L. A., 2005, In : Gastroenterology. 129, 3, p. 874-884 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  91. Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors

    Alazzouzi, H., Davalos, V., Kokko, A., Domingo, E., Woerner, S. M., Wilson, A. J., Konrad, L., Laiho, P., Espin, E., Armengol, M., Imai, K., Yamamoto, H., Mariadason, J. M., Gebert, J. F., Aaltonen, L. A., Schwartz, S. & Arango, D., 2005, In : Cancer Research. 65, 22, p. 10170-10173 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  92. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis

    Sweet, K., Willis, J., Zhou, X-P., Gallione, C., Sawada, T., Alhopuro, P., Khoo, S. K., Patocs, A., Martin, C., Bridgeman, S., Heinz, J., Pilarski, R., Lehtonen, R., Prior, T. W., Frebourg, T., Teh, B. T., Marchuk, D. A., Aaltonen, L. A. & Eng, C., 2005, In : JAMA : The Journal of the American Medical Association. 294, 19, p. 2465-2473 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  93. Molecular staging for survival prediction of colorectal cancer patients

    Eschrich, S., Yang, I., Bloom, G., Kwong, K. Y., Boulware, D., Cantor, A., Coppola, D., Kruhøffer, M., Ørntoft, T. F., Quackenbush, J., Yeatman, T. J. & Aaltonen, L. A., 2005, In : Journal of Clinical Oncology. 23, 15, p. 3526-3535 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  94. Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD alpha, and MO25 alpha, in Peutz-Jeghers syndrome

    Alhopuro, P., Katajisto, P., Lehtonen, R., Ylisaukko-oja, S. K., Näätsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, p. 1126-1129 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  95. Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

    Alhopuro, P., Katajisto, P., Lehtonen, R. J., Ylisaukko-oja, S., Näätäsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P. M., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, 6, p. 1126-1129 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  96. Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers

    Hienonen, T., Sammalkorpi, H., Enholm, S., Alhopuro, P., Barber, T. D., Lehtonen, R., Nupponen, N. N., Lehtonen, H., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Koistinen, R., Arango, D., Launonen, V., Vogelstein, B., Karhu, A. & Aaltonen, L. A., 2005, In : Cancer Research. 65, 11, p. 4607-4613 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  97. No MSH6 germline mutations in breast cancer families with colorectal and/or endometrial cancer

    Vahteristo, P., Ojala, S., Tamminen, A., Tommiska, J., Sammalkorpi, H., Kiuru-Kuhlefelt, S., Eerola, H., Aaltonen, L. A., Aittomäki, K. & Nevanlinna, H., 2005, In : Journal of Medical Genetics. 42, 4, p. e22 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  98. No germline FH mutations in familial breast cancer patients

    Kiuru, M. H. T., Lehtonen, R., Eerola, H., Aittomäki, K., Blomqvist, C., Nevanlinna, H., Aaltonen, L. A. & Launonen, V., 2005, In : European Journal of Human Genetics. 13, 4, p. 506-509 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  99. Numbers of mutations to different types of colorectal cancer

    Calabrese, P., Mecklin, J-P., Järvinen, H. J., Aaltonen, L. A., Tavare, S. & Shibata, D., 2005, In : BMC Cancer. 5, 126, 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  100. SMAD4 as a prognostic marker in colorectal cancer

    Alazzouzi, H., Alhopuro, P., Salovaara, R., Sammalkorpi, H., Järvinen, H. J., Mecklin, J-P., Hemminki, A., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 7, p. 2606-2611 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  101. SMAD4 levels and response to 5-fluorouracil in colorectal cancer

    Alhopuro, P., Alazzouzi, H., Sammalkorpi, H., Davalos, V., Salovaara, R., Hemminki, A., Järvinen, H. J., Mecklin, J-P., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 17, p. 6311-6316 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  102. The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population

    Rasinpera, H., Forsblom, C., Enattah, N. S., Halonen, P., Salo, K., Victorzon, M., Mecklin, J. P., Jarvinen, H., Enholm, S., Sellick, G., Alazzouzi, H., Houlston, R., Robinson, J., Groop, P. H., Tomlinson, I., Schwartz, S., Aaltonen, L. A., Jarvela, I. & FinnDiane Study Grp, 2005, In : Gut. 54, p. 643-647 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  103. The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck

    Alhopuro, P., Ylisaukko-oja, S., Koskinen, W., Bono, P., Arola, J., Järvinen, H. J., Mecklin, J-P., Atula, T., Kontio, R., Mäkitie, A., Suominen, S., Leivo, I., Vahteristo, P., Aaltonen, L-M., Aaltonen, L. A. & Suominen, S., 2005, In : Journal of Medical Genetics. 42, 9, p. 694-698 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  104. p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome

    Sotamaa, K., Liyanarachchi, S., Mecklin, J-P., Järvinen, H. J., Aaltonen, L. A., Peltomäki, P. & Chapelle, A. D. L., 2005, In : Clinical Cancer Research. 11, 19, p. 6840-6844 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  105. 2006
  106. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

    Ropero, S., Fraga, M. F., Ballestar, E., Hamelin, R., Yamamoto, H., Boix-Chornet, M., Caballero, R., Alaminos, M., Setien, F., Paz, M. F., Herranz, M., Palacios, J., Arango, D., Ørntoft, T. F., Aaltonen, L. A., Schwartz, S. & Esteller, M., 2006, In : Nature Genetics. 38, 5, p. 566-569 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  107. AIP-mutaatiot altistavat aivolisäkkeen adenomalle: [referaatti Science lehden artikkelista]

    Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., de Menis, E., Mäkinen, M. J., Launonen, V., Aaltonen, L. A. & Karhu, A., 2006, In : Duodecim. 122, 12, p. 1419-1420 2 p.

    Research output: Contribution to journalArticleScientific

  108. Analysis of fumarate hydratase mutations in a population-based series of early onset uterine leiomyosarcoma patients

    Ylisaukko-oja, S., Kiuru, M., Lehtonen, H. J., Lehtonen, R., Pukkala, E., Arola, J., Launonen, V. & Aaltonen, L. A., 2006, In : International Journal of Cancer. 119, 2, p. 283-287 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  109. CHEK2 I157T associates with familial and sporadic colorectal cancer: [electronic letter]

    Kilpivaara, O., Alhopuro, P., Vahteristo, P., Aaltonen, L. A. & Nevanlinna, H., 2006, In : Journal of Medical Genetics. 43, p. e34

    Research output: Contribution to journalArticleScientificpeer-review

  110. Distinct expression profile in fumarate-hydratase-deficient uterine fibroids

    Vanharanta, S., Pollard, P. J., Lehtonen, H. J., Laiho, P., Sjöberg, J., Leminen, A., Aittomäki, K., Arola, J., Kruhøffer, M., Ørntoft, T. F., Tomlinson, I. P., Kiuru, M., Arango, D. & Aaltonen, L. A., 2006, In : Human Molecular Genetics. 15, 1, p. 97-103 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  111. EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

    Kokko, A., Laiho, P., Lehtonen, R., Korja, S., Carvajal-Carmona, L., Järvinen, H. J., Mecklin, J-P., Eng, C., Schleutker, J., Tomlinson, I. P. M., Vahteristo, P. & Aaltonen, L. A., 2006, In : BMC Cancer. 6, 145, 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  112. EPHB4 and survival of colorectal cancer patients

    Davalos, V., Dopeso, H., Castano, J., Wilson, A. J., Vilardell, F., Romero-Gimenez, J., Espin, E., Armengol, M., Capella, G., Mariadason, J. M., Aaltonen, L. A., Schwartz, S. & Arango, D., 2006, In : Cancer Research. 66, 18, p. 8943-8948 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  113. Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma

    Ylisaukko-oja, S. K., Cybulski, C., Lehtonen, R., Kiuru, M., Matyjasik, J., Szymanska, A., Szymanska-Pasternak, J., Dyrskjot, L., Butzow, R., Orntoft, T. F., Launonen, V., Lubinski, J. & Aaltonen, L. A., 2006, In : European Journal of Human Genetics. 14, 7, p. 880-883 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  114. In response: SMAD4 levels and allelic imbalance in 18q21 in colorectal cancer

    Arango, D., Alhopuro, P. & Aaltonen, L. A., 2006, In : Clinical Cancer Research. 12, 5, p. 1654-1655 2 p.

    Research output: Contribution to journalArticleScientific

  115. Increased risk of cancer in patients with fumarate hydratase germline mutation

    Lehtonen, H., Kiuru, M., Ylisaukko-oja, S., Salovaara, R., Herva, R., Koivisto, P., Vierimaa, O., Aittomäki, K., Pukkala, E., Launonen, V., Aaltonen, L. A. & Lehtonen, H., 2006, In : Journal of Medical Genetics. 43, 6, p. 523-526 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  116. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome: [electronic letter]

    Volikos, E., Robinson, J., Aittomäki, K., Mecklin, J-P., Järvinen, H., Westerman, A. M., de Rooij, F. W. M., Vogel, T., Moeslein, G., Launonen, V., Tomlinson, I. P. M., Silver, A. R. J. & Aaltonen, L. A., 2006, In : Journal of Medical Genetics. 43, 5, p. e18 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  117. MDM2 SNP309 accelerates colorectal tumour formation in women

    Bond, G. L., Menin, C., Bertorelle, R., Alhopuro, P., Aaltonen, L. A. & Levine, A. J., 2006, In : Journal of Medical Genetics. 43, 12, p. 950-952 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  118. Modeling tumor predisposing FH mutations in yeast: effects on fumarase activity, growth phenotype and gene expression profile

    Kokko, A., Ylisaukko-oja, S., Kiuru, M., Takatalo, M., Salmikangas, P., Tuimala, J., Arango, D., Karhu, A., Aaltonen, L. A. & Jäntti, J., 2006, In : International Journal of Cancer. 118, 6, p. 1340-1345 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  119. Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies

    Karppinen, S-M., Barkardottir, R. B., Backenhorn, K., Sydenham, T., Syrjäkoski, K., Schleutker, J., Ikonen, T., Pylkäs, K., Rapakko, K., Erkko, H., Johannesdottir, G., Gerdes, A-M., Thomassen, M., Agnarsson, B. A., Grip, M., Kallioniemi, A., Kere, J., Aaltonen, L. A., Arason, A., Møller, P. & 3 othersKruse, T. A., Borg, Å. & Winqvist, R., 2006, In : Journal of Medical Genetics. 43, 11, p. 856-862 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  120. Periytyvän kasvainalttiuden molekyylitausta: Äyräpään luento

    Aaltonen, L. A., 2006, In : Duodecim. 122, 18, p. 2221-2230

    Research output: Contribution to journalArticleScientific

  121. Pituitary adenoma predisposition caused by germline mutations in the AIP gene

    Vierimaa, O., Georgitsi, M., Lehtonen, R., Vahteristo, P., Kokko, A., Raitila, A., Tuppurainen, K., Ebeling, T., Salmela, P. I., Paschke, R., Gundogdu, S., De Menis, E., Mäkinen, M. J., Launonen, V., Karhu, A. & Aaltonen, L. A., 2006, In : Science. 312, 5777, p. 1228-1230 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  122. Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers

    Hienonen, T., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Karhu, A. & Aaltonen, L. A., 2006, In : International Journal of Cancer. 118, 2, p. 505-508 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  123. 2007
  124. A recurrent mutation in PALB2 in Finnish cancer families

    Erkko, H., Xia, B., Nikkilä, J., Schleutker, J., Syrjäkoski, K., Mannermaa, A., Kallioniemi, A., Pylkäs, K., Karppinen, S-M., Rapakko, K., Miron, A., Sheng, Q., Li, G., Mattila, H., Bell, D. W., Haber, D. A., Grip, M., Reiman, M., Jukkola-Vuorinen, A., Mustonen, A. & 8 othersKere, J., Aaltonen, L. A., Kosma, V-M., Kataja, V., Soini, Y., Drapkin, R. I., Livingston, D. M. & Winqvist, R., 2007, In : Nature. 446, 7133, p. 316-319 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  125. Background mutation frequency in microsatellite-unstable colorectal cancer

    Sammalkorpi, H., Alhopuro, P., Lehtonen, R., Tuimala, J., Mecklin, J-P., Järvinen, H. J., Jiricny, J., Karhu, A. & Aaltonen, L. A., 2007, In : Cancer Research. 67, 12, p. 5691-5698 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  126. Blood-derived gene-expression profiling in unravelling susceptibility to recessive disease

    Vahteristo, P., Kokko, A., Saksela, O., Aittomäki, K. & Aaltonen, L. A., 2007, In : Journal of Medical Genetics. 44, 11, p. 718-720 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  127. Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer

    Niemela, A. M., Hynninen, P., Mecklin, J-P., Kuopio, T., Kokko, A., Aaltonen, L. A., Parkkila, A-K., Pastorekova, S., Pastorek, J., Waheed, A., Sly, W. S., Ørntoft, T. F., Kruhøffer, M., Haapasalo, H., Parkkila, S. & Kivelä, A., 2007, In : Cancer Epidemiology, Biomarkers & Prevention. 16, 9, p. 1760-1766 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  128. Clusterin expression in normal mucosa and colorectal cancer

    Andersen, C. L., Schepeler, T., Thornsen, K., Birkenkamp-Demtröder, K., Mansilla, F., Aaltonen, L. A., Laurberg, S. & Ørntoft, T. F., 2007, In : Molecular & Cellular Proteomics. 6, 6, p. 1039-1048 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  129. Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays: genetics and population analysis

    Laakso, M., Tuupanen, S., Karhu, A., Lehtonen, R., Aaltonen, L. A. & Hautaniemi, S., 2007, In : Bioinformatics. 23, 15, p. 1952-1961 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  130. Conventional renal cancer in a patient with fumarate hydratase mutation

    Lehtonen, H. J., Blanco, I., Piulats, J. M., Herva, R., Launonen, V. & Aaltonen, L. A., 2007, In : Human Pathology. 38, 5, p. 793-796 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  131. Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region

    Vanharanta, S., Wortham, N. C., Langford, C., El-Bahrawy, M., van der Spuy, Z., Sjöberg, J., Lehtonen, R., Karhu, A., Tomlinson, I. P. M. & Aaltonen, L. A., 2007, In : Genes, Chromosomes & Cancer. 46, 5, p. 451-458 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  132. Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome

    Mecklin, J-P., Aarnio, M., Läärä, E., Kairaluoma, M., Pylvänäinen, K., Peltomäki, P., Aaltonen, L. A. & Järvinen, H. J., 2007, In : Gastroenterology. 133, 4, p. 1093-1098 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  133. Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups

    Mansilla, F., Birkenkamp-Demtröder, K., Kruhøffer, M., Sørensen, F. B., Andersen, C. L., Laiho, P., Aaltonen, L. A., Verspaget, H. W. & Ørntoft, T. F., 2007, In : British Journal of Cancer. 96, 12, p. 1896-1903 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  134. Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing

    Aktan-Collan, K., Haukkala, A., Pylvänäinen, K., Järvinen, H. J., Aaltonen, L. A., Peltomäki, P., Rantanen, E., Kääriäinen, H. & Mecklin, J-P., 2007, In : Journal of Medical Genetics. 44, 11, p. 732-738 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  135. Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors

    Aaltonen, L. A., Johns, L., Järvinen, H. J., Mecklin, J-P. & Houlston, R. S., 2007, In : Clinical Cancer Research. 13, 1, p. 356-361 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  136. Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence

    Yang, Q., Zhang, R., Horikawa, I., Fujita, K., Afshar, Y., Kokko, A., Laiho, P., Aaltonen, L. A. & Harris, C. C., 2007, In : Cancer Research. 67, 24, p. 11677-11686 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  137. Gastroenterologia ja hepatologia

    Höckerstedt, K. (ed.), Aaltonen, L. A. (ed.), Kivilaakso, E. (ed.) & Färkkilä, M. (ed.), 2007, 1. [i.e. 3 täyd. uus.] p ed. Helsinki: Duodecim. 910 p.

    Research output: Book/ReportAnthology or special issueScientificpeer-review

  138. Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia

    Georgitsi, M., Raitila, A., Karhu, A., van der Luijt, R. B., Aalfs, C. M., Sane, T., Vierimaa, O., Mäkinen, M. J., Tuppurainen, K., Paschke, R., Gimm, O., Koch, C. A., Gundogdu, S., Lucassen, A., Tischkowitz, M., Izatt, L., Aylwin, S., Bano, G., Hodgson, S., De Menis, E. & 3 othersLaunonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 3321-3325 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  139. Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability

    Lehtonen, H. J., Mäkinen, M. J., Kiuru, M., Laiho, P., Herva, R., van Minderhout, I., Hogendoorn, P. C. W., Cornelisse, C., Devilee, P., Launonen, V. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 6, p. 1386-1389 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  140. Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations

    Georgitsi, M., Raitila, A., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Vierimaa, O., Paschke, R., Saeger, W., van der Luijt, R. B., Sane, T., Robledo, M., de Menis, E., Weil, R. J., Wasik, A., Zielinski, G., Lucewicz, O., Lubinski, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, p. 4101-4105 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  141. Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers

    Georgitsi, M., Karhu, A., Winqvist, R., Visakorpi, T., Waltering, K., Vahteristo, P., Launonen, V. & Aaltonen, L. A., 2007, In : British Journal of Cancer. 96, 2, p. 352-356 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  142. No evidence for association of NOD2 R702W and G908R with colorectal cancer

    Tuupanen, S., Alhopuro, P., Mecklin, J-P., Järvinen, H. J. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 1, p. 76-79 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  143. No evidence for dual role of loss of heterozygosity in hereditary non-polyposis colorectal cancer

    Tuupanen, S., Karhu, A., Järvinen, H. J., Mecklin, J-P., Launonen, V. & Aaltonen, L. A., 2007, In : Oncogene. 26, 17, p. 2513-2517 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  144. No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia

    Raitila, A., Georgitsi, M., Karhu, A., Tuppurainen, K., Mäkinen, M. J., Birkenkamp-Demtröder, K., Salmenkivi, K., Ørntoft, T. F., Arola, J., Launonen, V., Vahteristo, P. & Aaltonen, L. A., 2007, In : Endocrine - Related Cancer. 14, 3, p. 901-906 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  145. Paksusuolisyövälle altistavat geenivirheet ja niiden diagnostiikka

    Aaltonen, L. A. & Järvinen, H. J., 2007, Gastroenterologia ja hepatologia. Helsinki: Duodecim, p. 544-549 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

  146. Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro

    Birkenkamp-Demtroder, K., Mansilla, F., Sorensen, F. B., Kruhoffer, M., Cabezon, T., Christensen, L. L., Aaltonen, L. A., Verspaget, H. W. & Orntoft, T. F., 2007, In : Molecular oncology. 1, p. 181-195 15 p.

    Research output: Contribution to journalArticleScientificpeer-review

  147. Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis

    Laiho, P., Kokko, A., Vanharanta, S., Salovaara, R. K., Sammalkorpi, H., Järvinen, H. J., Mecklin, J-P., Karttunen, T. J., Tuppurainen, K., Davalos, V., Schwartz, S., Arango, D., Mäkinen, M. J. & Aaltonen, L. A., 2007, In : Oncogene. 26, 2, p. 312-320 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  148. Stress-induced expression of a novel variant of human fumarate hydratase (FH)

    Lehtonen, H. J., Ylisaukko-oja, S. K., Kiuru, M., Karhu, A., Lehtonen, R., Vanharanta, S., Jalanko, A., Aaltonen, L. A. & Launonen, V., 2007, In : Gene Expression. 14, p. 59-69 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  149. Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: an update

    Karhu, A. & Aaltonen, L. A., 2007, In : Human Molecular Genetics. 16, Rev.is, p. 1, s. R73-R79

    Research output: Contribution to journalReview ArticleScientificpeer-review

  150. Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells

    Alazzouzi, H., Suriano, G., Guerra, A., Plaja, A., Espin, E., Armengol, M., Alhopuro, P., Velho, S., Shinomura, Y., Gonzales-Aguilera, J. J., Yamamoto, H., Aaltonen, L. A., Moreno, V., Capella, G., Peinado, M. A., Seruca, R., Arango, D. & Schwartz, S., 2007, In : Journal of Medical Genetics. 44, 1, p. 75-80 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  151. 2008
  152. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

    Tomlinson, I. P. M., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium and EPICOLON Consortium, 2008, In : Nature Genetics. 40, 5, p. 623-630 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  153. ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer

    Siltanen, S., Syrjäkoski, K., Fagerholm, R., Ikonen, T., Lipman, P., Mallot, J., Holli, K., Tammela, T. L. J., Järvinen, H. J., Mecklin, J-P., Aittomäki, K., Blomqvist, C., Bailey-Wilson, J. E., Nevanlinna, H., Aaltonen, L. A., Schleutker, J. & Vahteristo, P., 2008, In : European Journal of Human Genetics. 16, 8, p. 983-991 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  154. Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution

    Tuupanen, S., Niittymäki, I., Nousiainen, K. J., Vanharanta, S., Mecklin, J-P., Nuorva, K., Järvinen, H., Hautaniemi, S., Karhu, A. & Aaltonen, L. A., 2008, In : Cancer Research. 68, 1, p. 14-17 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  155. Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas

    Georgitsi, M., De Menis, E., Cannavo, S., Mäkinen, M. J., Tuppurainen, K., Pauletto, P., Curto, L., Weil, R. J., Paschke, R., Zielinski, G., Wasik, A., Lubinski, J., Vahteristo, P., Karhu, A. & Aaltonen, L. A., 2008, In : Clinical Endocrinology. 69, 4, p. 621-627 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  156. DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers

    Jorissen, R. N., Lipton, L., Gibbs, P., Chapman, M., Desai, J., Jones, I. T., Yeatman, T. J., East, P., Tomlinson, I. P. M., erspaget, H. W., Aaltonen, L. A., Kruhøffer, M., Ørntoft, T. F., Andersen, C. L. & Sieber, O. M., 2008, In : Clinical Cancer Research. 14, 24, p. 8061-8069 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  157. Large genomic deletions in AIP in pituitary adenoma predisposition

    Georgitsi, M., Heliövaara, E., Paschke, R., Kumar, A. V. K., Tischkowitz, M., Vierimaa, O., Salmela, P., Sane, T., De Menis, E., Cannavo, S., Gundogdu, S., Lucassen, A., Izatt, L., Aylwin, S., Bano, G., Hodgson, S., Koch, C. A., Karhu, A. & Aaltonen, L. A., 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 10, p. 4146-4151 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  158. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

    Houlston, R. S., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium, Colorectal Cancer Association Study Consortium and International Colorectal Cancer Genetic Association Consortium, 2008, In : Nature Genetics. 40, 12, p. 1426-1435 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  159. Mutation analysis of MYH11 in acute myeloid leukemia

    Sammalkorpi, H., Alhopuro, P., Niittymäki, I., Ørntoft, T. F., Hokland, P., Karhu, A. & Aaltonen, L. A., 2008, In : Leukemia & lymphoma. 49, 9, p. 1829-1831 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  160. Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer

    Koski (Ahvenainen), T. A., Lehtonen, H. J., Lehtonen, R., Vahteristo, P., Aittomäki, K., Baynam, G., Dommering, C., Eng, C., Gruber, S. B., Grönberg, H., Harvima, R., Herva, R., Hietala, M., Kujala, M., Kääriäinen, H., Sunde, L., Vierimaa, O., Pollard, P. J., Tomlinson, I. P., Björck, E. & 2 othersAaltonen, L. A. & Launonen, V., 2008, In : Cancer Genetics and Cytogenetics. 183, 2, p. 83-88 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  161. Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer

    Pittman, A. M., Niittymäki, I., Tuupanen, S., Karhu, A., Aaltonen, L. A. & CORGI Consortium and EPICOLON Consortium, 2008, In : Human Molecular Genetics. 17, 23, p. 3720-3727 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  162. Smad4 haploinsufficiency: a matter of dosage

    Alberici, P., Gaspar, C., Franken, P., Gorski, M. M., de Vries, I., Scott, R. J., Ristimäki, A., Aaltonen, L. A. & Fodde, R., 2008, In : PathoGenetics. 1, 2, 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  163. Somatic mutation analysis of MYH11 in breast and prostate cancer

    Alhopuro, P., Karhu, A., Winqvist, R., Waltering, K., Visakorpi, T. & Aaltonen, L., 2008, In : BMC Cancer. 8, p. 263 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  164. Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

    Petrova, T., Nykänen, A., Norrmen, C., Ivanov, K. I., Andersson, L. C., Haglund, C., Puolakkainen, P., Wempe, F., von Melchner, H., Gradwohl, G., Vanharanta, S., Aaltonen, L. A., Saharinen, J. M. N., Gentile, M., Clarke, A., Taipale, J., Oliver, G. & Alitalo, K., 2008, In : Cancer Cell. 13, 5, p. 407-419 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  165. Unregulated smooth-muscle myosin in human intestinal neoplasia

    Alhopuro, P., Phichith, D., Tuupanen, S., Sammalkorpi, H., Nybondas, M., Saharinen, J., Robinson, J. P., Yang, Z., Chen, L-Q., Ørntoft, T. F., Mecklin, J-P., Järvinen, H., Eng, C., Moeslein, G., Shibata, D., Houlston, R. S., Lucassen, A., Tomlinson, I. P. M., Launonen, V., Ristimäki, A. & 4 othersArango, D., Karhu, A., Sweeney, H. L. & Aaltonen, L. A., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5513-5518 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  166. Dna-tieto liian tulkinnanvaraista jokamiehen huvitukseksi

    Aaltonen, L. A., 3 Jan 2008, In : Helsingin Sanomat.

    Research output: Contribution to journalArticleGeneral public

  167. 2009
  168. Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene

    Jennings, J. E., Georgitsi, M., Holdaway, I., Daly, A. F., Tichomirowa, M., Beckers, A., Aaltonen, L. A., Karhu, A. & Cameron, F. J., 2009, In : European Journal of Endocrinology. 161, 5, p. 799-804 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  169. An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression

    Yuan, Z., Shin, J., Wilson, A., Goel, S., Ling, Y-H., Ahmed, N., Dopeso, H., Jhawer, M., Nasser, S., Montagna, C., Fordyce, K., Augenlicht, L. H., Aaltonen, L. A., Arango, D., Weber, T. K. & Mariadason, J. M., 2009, In : Cancer Research. 69, 29, p. 7811-7818 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  170. Array comparative genomic hybridization identifies a distinct DNA copy number profile in renal cell cancer associated with hereditary leiomyomatosis and renal cell cancer

    Koski, T. A., Lehtonen, H. J., Jee, K. J., Ninomiya, S., Joosse, S. A., Vahteristo, P., Kiuru, M., Karhu, A., Sammalkorpi, H., Vanharanta, S., Lehtonen, R., Edgren, S. H. T., Nederlof, P. M., Hietala, M., Aittomäki, K., Herva, R., Knuutila, S., Aaltonen, L. A. & Launonen, V., 2009, In : Genes, Chromosomes & Cancer. 48, 7, p. 544-551 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  171. Aryl hydrocarbon receptor interacting protein mutations seem not to associate with familial non-medullary thyroid cancer

    Raitila, A., Georgitsi, M., Bonora, E., Vargiolu, M., Tuppurainen, K., Mäkinen, M. J., Vierimaa, O., Salmela, P. I., Launonen, V., Vahteristo, P., Aaltonen, L. A., Romeo, G. & Karhu, A., 2009, In : Journal of Endocrinological Investigation. 32, 5, p. 426-429 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  172. Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas

    Raimundo, N., Vanharanta, S., Aaltonen, L. A., Hovatta, I. & Suomalainen, A., 2009, In : Oncogene. 28, 9, p. 1261-1273 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  173. Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer

    Andersen, C. L., Christensen, L. L., Thorsen, K., Schepeler, T., Sorensen, F. B., Verspaget, H. W., Simon, R., Kruhoffer, M., Aaltonen, L. A., Laurberg, S. & Ørntoft, T. F., 2009, In : British Journal of Cancer. 100, 3, p. 511-523 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  174. Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer

    Jorissen, R. N., Gibbs, P., Christie, M., Prakash, S., Lipton, L., Desai, J., Kerr, D., Aaltonen, L. A., Arango, D., Kruhoffer, M., Orntoft, T. F., Andersen, C. L., Gruidl, M., Kamath, V. P., Eschrich, S., Yeatman, T. J. & Sieber, O. M., 2009, In : Clinical Cancer Research. 15, p. 7642-7651 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  175. Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition

    Vierimaa, O., Villablanca, A., Alimov, A., Georgitsi, M., Raitila, A., Vahteristo, P., Larsson, C., Ruokonen, A., Eloranta, E., Ebeling, T. M. L., Ignatius, J., Aaltonen, L. A., Leisti, J. & Salmela, P. I., 2009, In : Journal of Endocrinological Investigation. 32, 6, p. 512-518 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  176. Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members

    Järvinen, H. J., Renkonen-Sinisalo, L., Aktan-Collan, K., Peltomäki, P., Aaltonen, L. A. & Mecklin, J-P., 2009, In : Journal of Clinical Oncology. 27, 28, p. 4793-4797 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  177. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

    Tuupanen, S., Turunen, M., Lehtonen, R., Hallikas, O., Vanharanta, S., Kivioja, T., Björklund, M., Wei, G., Yan, J., Niittymäki, I., Mecklin, J-P., Järvinen, H., Ristimäki, A., Di-Bernardo, M., East, P., Carvajal-Carmona, L., Houlston, R. S., Tomlinson, I., Palin, K., Ukkonen, E. & 3 othersKarhu, A., Taipale, J. & Aaltonen, L. A., 2009, In : Nature Genetics. 41, 8, p. 885-890 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  178. The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas

    Heliövaara, E., Raitila, A., Launonen, V., Paetau, A., Arola, J., Lehtonen, H., Sane, T., Weil, R. J., Vierimaa, O., Salmela, P., Tuppurainen, K., Mäkinen, M., Aaltonen, L. A. & Karhu, A., 2009, In : The American Journal of Pathology. 175, 6, p. 2501-2507 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  179. 2010
  180. A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants

    Theodoratou, E., Campbell, H., Tenesa, A., Houlston, R., Webb, E., Lubbe, S., Broderick, P., Gallinger, S., Croitoru, E. M., Jenkins, M. A., Win, A. K., Cleary, S. P., Koessler, T., Pharoah, P. D., Kuery, S., Bezieau, S., Buecher, B., Ellis, N. A., Peterlongo, P., Offit, K. & 12 othersAaltonen, L. A., Enholm, S., Lindblom, A., Zhou, X-L., Tomlinson, I. P., Moreno, V., Blanco, I., Capella, G., Barnetson, R., Porteous, M. E., Dunlop, M. G. & Farrington, S. M., 2010, In : British Journal of Cancer. 103, 12, p. 1875-1884 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  181. Allelic Variation at the 8q23.3 Colorectal Cancer Risk Locus Functions as a Cis-Acting Regulator of EIF3H

    Pittman, A. M., Naranjo, S., Jalava, S. E., Twiss, P., Ma, Y., Olver, B., Lloyd, A., Vijayakrishnan, J., Qureshi, M., Broderick, P., van Wezel, T., Morreau, H., Tuupanen, S., Aaltonen, L. A., Eva Alonso, M., Manzanares, M., Gavilan, A., Visakorpi, T., Luis Gomez-Skarmeta, J. & Houlston, R. S., 2010, In : PLoS Genetics. 6, 9 , p. e1001126 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  182. COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer

    Tomlinson, I. P. M., Dunlop, M., Campbell, H., Zanke, B., Gallinger, S., Hudson, T., Koessler, T., Pharoah, P. D., Niittymäki, I., Tuupanen, S., Aaltonen, L. A., Hemminki, K., Lindblom, A., Forsti, A., Sieber, O., Lipton, L., van Wezel, T., Morreau, H., Wijnen, J. T., Devilee, P. & 31 othersMatsuda, K., Nakamura, Y., Castellvi-Bel, S., Ruiz-Ponte, C., Castells, A., Carracedo, A., Ho, J. W. C., Sham, P., Hofstra, R. M. W., Vodicka, P., Brenner, H., Hampe, J., Schafmayer, C., Tepel, J., Schreiber, S., Volzke, H., Lerch, M. M., Schmidt, C. A., Buch, S., Moreno, V., Villanueva, C. M., Peterlongo, P., Radice, P., Echeverry, M. M., Velez, A., Carvajal-Carmona, L., Scott, R., Penegar, S., Broderick, P., Tenesa, A. & Houlston, R. S., 2010, In : British Journal of Cancer. 102, 2, p. 447-454 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  183. Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line AIP Mutations and Pituitary Adenomas: An International Collaborative Study

    Daly, A. F., Tichomirowa, M. A., Petrossians, P., Heliövaara, E., Jaffrain-Rea, M-L., Barlier, A., Naves, L. A., Ebeling, T., Karhu, A., Raappana, A., Cazabat, L., De Menis, E., Fajardo Montanana, C., Raverot, G., Weil, R. J., Sane, T., Maiter, D., Neggers, S., Yaneva, M., Tabarin, A. & 43 othersVerrua, E., Eloranta, E., Murat, A., Vierimaa, O., Salmela, P. I., Emy, P., Toledo, R. A., Isabel Sabate, M., Villa, C., Popelier, M., Salvatori, R., Jennings, J., Ferrandez Longas, A., Labarta Aizpun, J. I., Georgitsi, M., Paschke, R., Ronchi, C., Välimäki, M., Saloranta, C., De Herder, W., Cozzi, R., Guitelman, M., Magri, F., Lagonigro, M. S., Halaby, G., Corman, V., Hagelstein, M-T., Vanbellinghen, J-F., Barra, G. B., Gimenez-Roqueplo, A-P., Cameron, F. J., Borson-Chazot, F., Holdaway, I., Toledo, S. P. A., Stalla, G. K., Spada, A., Zacharieva, S., Bertherat, J., Brue, T., Bours, V., Chanson, P., Aaltonen, L. A. & Beckers, A., 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 11, p. E373-E383 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  184. Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

    Ashrafian, H., O'Flaherty, L., Adam, J., Steeples, V., Chung, Y-L., East, P., Vanharanta, S., Lehtonen, H., Nye, E., Hatipoglu, E., Miranda, M., Howarth, K., Shukla, D., Troy, H., Griffiths, J., Spencer-Dene, B., Yusuf, M., Volpi, E., Maxwell, P. H., Stamp, G. & 11 othersPoulsom, R., Pugh, C. W., Costa, B., Bardella, C., Di Renzo, M. F., Kotlikoff, M. I., Launonen, V., Aaltonen, L., El-Bahrawy, M., Tomlinson, I. & Pollard, P. J., 2010, In : Cancer Research. 70, 22, p. 9153-9165 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  185. Low-Penetrance Susceptibility Variants in Familial Colorectal Cancer

    Niittymaki, I., Kaasinen, E., Tuupanen, S., Karhu, A., Jarvinen, H., Mecklin, J-P., Tomlinson, I. P. M., Di Bernardo, M. C., Houlston, R. S. & Aaltonen, L. A., 2010, In : Cancer Epidemiology, Biomarkers & Prevention. 19, 6, p. 1478-1483 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  186. Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

    Houlston, R. S., Cheadle, J., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., Spain, S. L., Broderick, P., Domingo, E., Farrington, S., Prendergast, J. G. D., Pittman, A. M., Theodoratou, E., Smith, C. G., Olver, B., Walther, A., Barnetson, R. A., Churchman, M., Jaeger, E. E. M., Penegar, S. & 26 othersBarclay, E., Martin, L., Gorman, M., Mager, R., Johnstone, E., Midgley, R., Niittymäki, I., Tuupanen, S., Colley, J., Idziaszczyk, S., Thomas, H. J. W., Lucassen, A. M., Evans, D. G. R., Maher, E. R., Maughan, T., Dimas, A., Dermitzakis, E., Cazier, J-B., Aaltonen, L. A., Pharoah, P., Kerr, D. J., Carvajal-Carmona, L. G., Campbell, H., Dunlop, M. G., Tomlinson, I. P. M. & CORGI Consortium, COGENT Consortium, COINB Collaborative Grp, COIN Collaborative Grp, 2010, In : Nature Genetics. 42, 11, p. 973-U89 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  187. Mice with Inactivation of Aryl Hydrocarbon Receptor-Interacting Protein (Aip) Display Complete Penetrance of Pituitary Adenomas with Aberrant ARNT Expression

    Raitila, A., Lehtonen, H. J., Arola, J., Heliovaara, E., Ahlsten, M., Georgitsi, M., Jalanko, A., Paetau, A., Aaltonen, L. A. & Karhu, A., 2010, In : The American Journal of Pathology. 177, 4, p. 1969-1976 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  188. Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours

    Velho, S., Oliveira, C., Paredes, J., Sousa, S., Leite, M., Matos, P., Milanezi, F., Ribeiro, A. S., Mendes, N., Licastro, D., Karhu, A., Oliveira, M. J., Ligtenberg, M., Hamelin, R., Carneiro, F., Lindblom, A., Peltomaki, P., Castedo, S., Schwartz, S., Jordan, P. & 6 othersAaltonen, L. A., Hofstra, R. M. W., Suriano, G., Stupka, E., Fialho, A. M. & Seruca, R., 2010, In : Human Molecular Genetics. 19, 4, p. 697-706 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  189. Mutations in the Circadian Gene CLOCK in Colorectal Cancer

    Alhopuro, P., Björklund, M., Sammalkorpi, H. P., Turunen, M., Tuupanen, S. J., Bistrom, M., Niittymäki, I., Lehtonen, H., Kivioja, T., Launonen, V., Saharinen, J. M. N., Nousiainen, K. J., Hautaniemi, S., Nuorva, K., Mecklin, J-P., Järvinen, H., Orntoft, T., Arango, D., Lehtonen, R. J., Karhu, A. I. & 2 othersTaipale, J. & Aaltonen, L. A., 2010, In : Molecular Cancer Research. 8, 7, p. 952-960 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  190. No evidence for a genetic modifier for renal cell cancer risk in HLRCC syndrome

    Vahteristo, P., Koski, T. A., Naatsaari, L., Kiuru, M., Karhu, A., Herva, R., Sallinen, S-L., Vierimaa, O., Bjorck, E., Richard, S., Gardie, B., Bessis, D., Van Glabeke, E., Blanco, I., Houlston, R., Senter, L., Hietala, M., Aittomaki, K., Aaltonen, L. A., Launonen, V. & 1 othersLehtonen, R., 2010, In : Familial Cancer. 9, p. 245-251 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  191. Recessively inherited right atrial isomerism caused by mutations in growth/differentiation factor 1 (GDF1)

    Kaasinen, E., Aittomaki, K., Eronen, M., Vahteristo, P., Karhu, A., Mecklin, J-P., Kajantie, E., Aaltonen, L. A. & Lehtonen, R., 2010, In : Human Molecular Genetics. 19, p. 2747-2753 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  192. Somatic mutations and germline sequence variants in patients with familial colorectal cancer

    Gylfe, A. E., Sirkiä, J., Ahlsten, M., Järvinen, H., Mecklin, J-P., Karhu, A. & Aaltonen, L. A., 2010, In : International Journal of Cancer. 127, 12, p. 2974-2980 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  193. 2011
  194. Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

    Bardella, C., El-Bahrawy, M., Frizzell, N., Adam, J., Ternette, N., Hatipoglu, E., Howarth, K., O'Flaherty, L., Roberts, I., Turner, G., Taylor, J., Giaslakiotis, K., Macaulay, V. M., Harris, A. L., Chandra, A., Lehtonen, H. J., Launonen, V., Aaltonen, L. A., Pugh, C. W., Mihai, R. & 6 othersTrudgian, D., Kessler, B., Baynes, J. W., Ratcliffe, P. J., Tomlinson, I. P. & Pollard, P. J., 2011, In : Journal of Pathology. 225, 1, p. 4-11 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  195. Analysis of KLHDC8B in familial nodular lymphocyte predominant Hodgkin lymphoma

    Saarinen, S., Vahteristo, P., Launonen, V., Franssila, K., Kivirikko, S., Lehtonen, R., Bain, B. J., Bauduer, F., Unal, A., Aaltonen, L. A. & Aittomaki, K., 2011, In : British Journal of Haematology. 154, 3, p. 413-415 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  196. Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations

    Stefanius, K., Kantola, T., Tuomisto, A., Vahteristo, P., Karttunen, T. J., Aaltonen, L. A., Makinen, M. J. & Karhu, A., 2011, In : Virchows Archiv. 458, 2, p. 213-219 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  197. Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma

    Saarinen, S., Aavikko, M., Aittomaki, K., Launonen, V., Lehtonen, R., Franssila, K., Lehtonen, H. J., Kaasinen, E., Broderick, P., Tarkkanen, J., Bain, B. J., Bauduer, F., Unal, A., Swerdlow, A. J., Cooke, R., Makinen, M. J., Houlston, R., Vahteristo, P. & Aaltonen, L. A., 2011, In : Blood. 118, 3, p. 493-498 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  198. High frequency of TTK mutations in microsatellite-unstable colorectal cancer and evaluation of their effect on spindle assembly checkpoint

    Niittymaki, I., Gylfe, A., Laine, L., Laakso, M., Lehtonen, H. J., Kondelin, J., Tolvanen, J., Nousiainen, K., Pouwels, J., Jarvinen, H., Nuorva, K., Mecklin, J-P., Makinen, M., Ristimaki, A., Orntoft, T. F., Hautaniemi, S., Karhu, A., Kallio, M. J. & Aaltonen, L. A., 2011, In : Carcinogenesis. 32, 3, p. 305-311 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  199. KSHV-Initiated Notch Activation Leads to Membrane-Type-1 Matrix Metalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition

    Cheng, F., Pekkonen, P., Laurinavicius, S., Sugiyama, N., Henderson, S., Guenther, T., Rantanen, V., Kaivanto, E., Aavikko, M., Sarek, G., Hautaniemi, S., Biberfeld, P., Aaltonen, L., Grundhoff, A., Boshoff, C., Alitalo, K., Lehti, K. & Ojala, P. M., 2011, In : Cell Host & Microbe. 10, 6, p. 577-590 14 p.

    Research output: Contribution to journalArticleScientificpeer-review

  200. KSHV-Initiated Notch Activation Leads to Membrane-Type-1MatrixMetalloproteinase-Dependent Lymphatic Endothelial-to-Mesenchymal Transition

    Cheng, F., Pekkonen, P. M., Laurinavicius, S., Sugiyama, N., Henderson, S., Günther, T., Rantanen, V., Kaivanto, E., Aavikko, M., Sarek, G., Hautaniemi, S., Biberfeld, P., Aaltonen, L. A., Grundhoff, A., Boshoff, C., Alitalo, K., Lehti, K. & Ojala, P., 2011, In : Cell Host & Microbe. 10, 6, p. 577-590 14 p.

    Research output: Contribution to journalArticleScientificpeer-review

  201. MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

    Mäkinen, N., Mehine, M., Tolvanen, J., Kaasinen, E., Li, Y., Lehtonen, H. J., Gentile, M., Yan, J., Enge, M., Taipale, M., Aavikko, M., Katainen, R., Virolainen, E., Böhling, T., Koski, T. A., Launonen, V., Sjöberg, J., Taipale, J., Vahteristo, P. & Aaltonen, L. A., 2011, In : Science Progress. 334, 6053, p. 252-255 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  202. Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer

    Tomlinson, I. P. M., Carvajal-Carmona, L. G., Dobbins, S. E., Tenesa, A., Jones, A. M., Howarth, K., Palles, C., Broderick, P., Jaeger, E. E. M., Farrington, S., Lewis, A., Prendergast, J. G. D., Pittman, A. M., Theodoratou, E., Olver, B., Walker, M., Penegar, S., Barclay, E., Whiffin, N., Martin, L. & 31 othersBallereau, S., Lloyd, A., Gorman, M., Lubbe, S., Howie, B., Marchini, J., Ruiz-Ponte, C., Fernandez-Rozadilla, C., Castells, A., Carracedo, A., Castellvi-Bel, S., Duggan, D., Conti, D., Cazier, J-B., Campbell, H., Sieber, O., Lipton, L., Gibbs, P., Martin, N. G., Montgomery, G. W., Young, J., Baird, P. N., Gallinger, S., Newcomb, P., Hopper, J., Jenkins, M. A., Aaltonen, L. A., Kerr, D. J., Cheadle, J., Pharoah, P. & CORGI Collaborators, COGENT Consortium, EPICOLON Consortium, 2011, In : PLoS Genetics. 7, 6, p. e1002105 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  203. Mutations in BRIP1 confer high risk of ovarian cancer

    Rafnar, T., Gudbjartsson, D. F., Sulem, P., Jonasdottir, A., Sigurdsson, A., Jonasdottir, A., Besenbacher, S., Lundin, P., Stacey, S. N., Gudmundsson, J., Magnusson, O. T., le Roux, L., Orlygsdottir, G., Helgadottir, H. T., Johannsdottir, H., Gylfason, A., Tryggvadottir, L., Jonasson, J. G., de Juan, A., Ortega, E. & 25 othersRamon-Cajal, J. M., Garcia-Prats, M. D., Mayordomo, C., Panadero, A., Rivera, F., Aben, K. K. H., van Altena, A. M., Massuger, L. F. A. G., Aavikko, M., Kujala, P. M., Staff, S., Aaltonen, L. A., Olafsdottir, K., Bjornsson, J., Kong, A., Salvarsdottir, A., Saemundsson, H., Olafsson, K., Benediktsdottir, K. R., Gulcher, J., Masson, G., Kiemeney, L. A., Mayordomo, J. I., Thorsteinsdottir, U. & Stefansson, K., 2011, In : Nature Genetics. 43, 11, p. 1104-U91 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  204. No evidence of RET germline mutations in familial pituitary adenoma

    Heliovaara, E., Tuupanen, S., Ahlsten, M., Hodgson, S., de Menis, E., Kuismin, O., Izatt, L., Gardner, R. J. M., Gundogdu, S., Lucassen, A., Arola, J., Tuomisto, A., Makinen, M., Karhu, A. & Aaltonen, L. A., 2011, In : Journal of Molecular Endocrinology. 46, 1, p. 1-8 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  205. Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci

    Niittymäki, I., Tuupanen, S., Li, Y., Järvinen, H., Mecklin, J-P., Tomlinson, I. P. M., Houlston, R. S., Karhu, A. & Aaltonen, L. A., 2011, In : BMC Medical Genetics. 12, 6 p., 23.

    Research output: Contribution to journalArticleScientificpeer-review

  206. The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians

    Knappskog, S., Bjornslett, M., Myklebust, L. M., Huijts, P. E. A., Vreeswijk, M. P., Edvardsen, H., Guo, Y., Zhang, X., Yang, M., Ylisaukko-oja, S. K., Alhopuro, P., Arola, J., Tollenaar, R. A. E. M., van Asperen, C. J., Seynaeve, C., Staalesen, V., Chrisanthar, R., Lokkevik, E., Salvesen, H. B., Evans, D. G. & 13 othersNewman, W. G., Lin, D., Aaltonen, L. A., Borresen-Dale, A-L., Tell, G. S., Stoltenberg, C., Romundstad, P., Hveem, K., Lillehaug, J. R., Vatten, L., Devilee, P., Dorum, A. & Lonning, P. E., 2011, In : Cancer Cell. 19, 2, p. 273-282 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  207. Variants in the Netrin-1 Receptor UNC5C Prevent Apoptosis and Increase Risk of Familial Colorectal Cancer

    Coissieux, M-M., Tomsic, J., Castets, M., Hampel, H., Tuupanen, S., Andrieu, N., Comeras, I., Drouet, Y., Lasset, C., Liyanarachchi, S., Mazelin, L., Puisieux, A., Saurin, J-C., Scoazec, J-Y., Wang, Q., Aaltonen, L., Tanner, S. M., de la Chapelle, A., Bernet, A. & Mehlen, P., 2011, In : Gastroenterology. 141, 6, p. 2039-2046 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  208. Äyräpään palkinto 2011 Juha Kerelle

    Puolakkainen, P., Aaltonen, L. & Alitalo, K., 2011, In : Duodecim. 127, 1, p. 94-95 2 p.

    Research output: Contribution to journalArticleProfessional

  209. MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

    Mäkinen, N., Heinonen, H-R., Moore, S., Tomlinson, I. P. M., van der Spuy, Z. M. & Aaltonen, L. A., Dec 2011, In : Oncotarget. 2, 12, p. 966-969 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  210. 2012
  211. A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer

    Pelttari, L. M., Kiiski, J., Nurminen, R., Kallioniemi, A., Schleutker, J., Gylfe, A., Aaltonen, L. A., Leminen, A., Heikkilä, P., Blomqvist, C., Butzow, R., Aittomäki, K. & Nevanlinna, H., 2012, In : Journal of Medical Genetics. 49, 7, p. 429-432 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  212. Candidate driver genes in microsatellite-unstable colorectal cancer

    Alhopuro, P. P., Sammalkorpi, H. P., Niittymäki, I., Biström, M., Raitila, A., Saharinen, J. M. N., Nousiainen, K. J., Lehtonen, H., Heliövaara, E., Puhakka, J., Tuupanen, S., Sousa, S., Seruca, R., Ferreira, A. M., Hofstra, R. M. W., Mecklin, J-P., Järvinen, H., Ristimäki, A., Orntoft, T. F., Hautaniemi, S. & 3 othersArango, D., Karhu, A. I. & Aaltonen, L. A., 2012, In : International Journal of Cancer. 130, 7, p. 1558–1566 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  213. Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583

    Tuupanen, S., Yan, J., Turunen, M., Gylfe, A. E., Kaasinen, E., Li, L., Eng, C., Culver, D. A., Kalady, M. F., Pennison, M. J., Pasche, B., Manne, U., de la Chapelle, A., Hampel, H., Henderson, B. E., Le Marchand, L., Hautaniemi, S., Askhtorab, H., Smoot, D., Sandler, R. S. & 6 othersKeku, T., Kupfer, S. S., Ellis, N. A., Haiman, C. A., Taipale, J. & Aaltonen, L. A., 2012, In : Cancer Genetics. 205, 1-2, p. 25-33 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  214. Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

    Dunlop, M. G., Dobbins, S. E., Farrington, S. M., Jones, A. M., Palles, C., Whiffin, N., Tenesa, A., Spain, S., Broderick, P., Ooi, L-Y., Domingo, E., Smillie, C., Henrion, M., Frampton, M., Martin, L., Grimes, G., Gorman, M., Semple, C., Ma, Y. P., Barclay, E. & 31 othersPrendergast, J., Cazier, J-B., Olver, B., Penegar, S., Lubbe, S., Chander, I., Carvajal-Carmona, L. G., Ballereau, S., Lloyd, A., Vijayakrishnan, J., Zgaga, L., Rudan, I., Theodoratou, E., Starr, J. M., Deary, I., Kirac, I., Kovacevic, D., Aaltonen, L. A., Renkonen-Sinisalo, L., Mecklin, J-P., Matsuda, K., Nakamura, Y., Okada, Y., Gallinger, S., Duggan, D. J., Conti, D., Newcomb, P., Hopper, J., Jenkins, M. A., Schumacher, F. & Swedish Low-Risk Colorectal Canc, Coin Collaborative Grp, Colorectal Tumour Gene Identificat, 2012, In : Nature Genetics. 44, 7, p. 770-U197 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  215. Rule-based induction method for haplotype comparison and identification of candidate disease loci

    Karinen, S. H., Saarinen, S., Lehtonen, R. J., Rastas, P., Vahteristo, P. M., Aaltonen, L. A. & Hautaniemi, S., 2012, In : Genome medicine. 4, 3, p. 21

    Research output: Contribution to journalArticleScientificpeer-review

  216. Strong family history of uterine leiomyomatosis warrants fumarate hydratase mutation screening

    Tolvanen, J., Uimari, O., Ryynanen, M., Aaltonen, L. A. & Vahteristo, P., 2012, In : Human Reproduction. 27, 6, p. 1865-1869 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  217. Villin Expression Is Frequently Lost in Poorly Differentiated Colon Cancer

    Arango, D., Al-Obaidi, S., Williams, D. S., Dopeso, H., Mazzolini, R., Corner, G., Byun, D-S., Carr, A. A., Murone, C., Toegel, L., Zeps, N., Aaltonen, L. A., Iacopetta, B. & Mariadason, J. M., 2012, In : The American Journal of Pathology. 180, 4, p. 1509-1521 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  218. Brush border Myosin Ia has tumor suppressor activity in the intestine

    Mazzolini, R., Dopeso, H., Mateo-Lozano, S., Chang, W., Rodrigues, P., Bazzocco, S., Alazzouzi, H., Landolfi, S., Hernandez-Losa, J., Andretta, E., Alhopuro, P., Espin, E., Armengol, M., Tabernero, J., Ramon y Cajal, S., Kloor, M., Gebert, J., Mariadason, J. M., Schwartz, S., Aaltonen, L. A. & 2 othersMooseker, M. S. & Arango, D., 31 Jan 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1530-1535 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  219. Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13

    Spain, S. L., Carvajal-Carmona, L. G., Howarth, K. M., Jones, A. M., Su, Z., Cazier, J-B., Williams, J., Aaltonen, L. A., Pharoah, P., Kerr, D. J., Cheadle, J., Li, L., Casey, G., Vodicka, P., Sieber, O., Lipton, L., Gibbs, P., Martin, N. G., Montgomery, G. W., Young, J. & 11 othersBaird, P. N., Morreau, H., van Wezel, T., Ruiz-Ponte, C., Fernandez-Rozadilla, C., Carracedo, A., Castells, A., Castellvi-Bel, S., Dunlop, M., Houlston, R. S. & Tomlinson, I. P. M., 15 Feb 2012, In : Human Molecular Genetics. 21, 4, p. 934-946 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  220. Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer

    Saarinen, S., Vahteristo, P., Lehtonen, R., Aittomäki, K., Launonen, V., Kiviluoto, T. & Aaltonen, L. A., Sep 2012, In : Familial Cancer. 11, 3, p. 525-528 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  221. Loss of SUFU Function in Familial Multiple Meningioma

    Aavikko, M., Li, S-P., Saarinen, S., Alhopuro, P., Kaasinen, E., Morgunova, E., Li, Y., Vesanen, K., Smith, M. J., Evans, D. G. R., Pöyhönen, M., Kiuru, A., Auvinen, A., Aaltonen, L. A., Taipale, J. & Vahteristo, P., 7 Sep 2012, In : American Journal of Human Genetics. 91, 3, p. 520-526 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  222. MED12 exon 2 mutations in common and histopathological variants of uterine leiomyoma and leiomyosarcoma

    Makinen, N., Arola, J., Vahteristo, P., Lehtonen, H. J., Heinonen, H., Butzow, R. & Aaltonen, L. A., Oct 2012, In : Histopathology. 61, p. 101-101 1 p.

    Research output: Contribution to journalMeeting AbstractResearchpeer-review

  223. Identification of Lynch Syndrome Among Patients With Colorectal Cancer

    EPICOLON Consortium, 17 Oct 2012, In : JAMA : The Journal of the American Medical Association. 308, 15, p. 1555-1565 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  224. Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer

    Kämpjärvi, K., Mäkinen, N., Kilpivaara, O., Arola, J., Heinonen, H-R., Bohm, J., Abdel-Wahab, O., Lehtonen, H. J., Pelttari, L. M., Mehine, M., Schrewe, H., Nevanlinna, H., Levine, R. L., Hokland, P., Bohling, T., Mecklin, J-P., Butzow, R., Aaltonen, L. A. & Vahteristo, P., 6 Nov 2012, In : British Journal of Cancer. 107, 10, p. 1761-1765 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  225. Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients

    Pelttari, L. M., Nurminen, R., Gylfe, A., Aaltonen, L. A., Schleutker, J. & Nevanlinna, H., 23 Nov 2012, In : BMC Cancer. 12, Article Number: 552, 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  226. Segregation of a Missense Variant in Enteric Smooth Muscle Actin gamma-2 With Autosomal Dominant Familial Visceral Myopathy

    Lehtonen, H. J., Sipponen, T., Tojkander, S., Karikoski, R., Jarvinen, H., Laing, N. G., Lappalainen, P., Aaltonen, L. A. & Tuupanen, S., Dec 2012, In : Gastroenterology. 143, 6, p. 1482-+ 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  227. Mice Lacking a Myc Enhancer That Includes Human SNP rs6983267 Are Resistant to Intestinal Tumors

    Sur, I. K., Hallikas, O., Vähärautio, A. V., Yan, J., Turunen, M., Enge, M., Taipale, M., Karhu, A., Aaltonen, L. A. & Taipale, J., 7 Dec 2012, In : Science. 338, 6112, p. 1360-1363 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  228. 2013
  229. Nationwide Registry-Based Analysis of Cancer Clustering Detects Strong Familial Occurrence of Kaposi Sarcoma

    Kaasinen, E., Aavikko, M., Vahteristo, P., Patama, T., Li, Y., Saarinen, S., Kilpivaara, O., Pitkänen, E., Knekt, P., Laaksonen, M., Lehtonen, R., Artama, M., Aaltonen, L. A. & Pukkala, E., 24 Jan 2013, In : PLoS One. 8, 1, p. Article Number: e55209 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  230. HOXB13 G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk

    Laitinen, V. H., Wahlfors, T., Saaristo, L., Rantapero, T., Pelttari, L. M., Kilpivaara, O., Laasanen, S-L., Kallioniemi, A., Nevanlinna, H., Aaltonen, L., Vessella, R. L., Auvinen, A., Visakorpi, T., Tammela, T. L. J. & Schleutker, J., Mar 2013, In : Cancer Epidemiology, Biomarkers & Prevention. 22, 3, p. 452-460 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  231. High Familial Risk in Nodular Lymphocyte-Predominant Hodgkin Lymphoma

    Saarinen, S., Pukkala, E., Vahteristo, P., Makinen, M. J., Franssila, K. & Aaltonen, L. A., 1 Mar 2013, In : Journal of Clinical Oncology. 31, 7, p. 938-943 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  232. Diagnostic Cancer Genome Sequencing and the Contribution of Germline Variants

    Kilpivaara, O. & Aaltonen, L. A., 29 Mar 2013, In : Science. 339, 6127, p. 1559-1562 4 p.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  233. Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene

    Beckers, A., Aaltonen, L. A., Daly, A. F. & Karhu, A., Apr 2013, In : Endocrine Reviews. 34, 2, p. 239-277 39 p.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  234. Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene

    Saarinen, S., Kaasinen, E., Karjalainen-Lindsberg, M., Vesanen, K., Aavikko, M., Katainen, R., Taskinen, M., Kytola, S., Leppä, S. M., Hietala, M., Vahteristo, P. & Aaltonen, L. A., 25 Apr 2013, In : Blood. 121, 17, p. 3428-3430 3 p.

    Research output: Contribution to journalArticleScientificpeer-review

  235. Trilateral Retinoblastoma in a Patient With Peutz-Jeghers Syndrome

    Raizis, A. M., Van Mater, D., Aaltonen, L. A., Lohmann, D., Cheale, M. S., Bickley, V. M., George, P. M., Zhou, Y. & Rosoff, P. M., May 2013, In : American Journal of Medical Genetics. Part A. 161A, 5, p. 1096-1100 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  236. Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals

    Dunlop, M. G., Tenesa, A., Farrington, S. M., Ballereau, S., Brewster, D. H., Koessler, T., Pharoah, P., Schafmayer, C., Hampe, J., Voelzke, H., Chang-Claude, J., Hoffmeister, M., Brenner, H., von Holst, S., Picelli, S., Lindblom, A., Jenkins, M. A., Hopper, J. L., Casey, G., Duggan, D. & 26 othersNewcomb, P. A., Abuli, A., Bessa, X., Ruiz-Ponte, C., Castellvi-Bel, S., Niittymaeki, I., Tuupanen, S., Karhu, A., Aaltonen, L., Zanke, B., Hudson, T., Gallinger, S., Barclay, E., Martin, L., Gorman, M., Carvajal-Carmona, L., Walther, A., Kerr, D., Lubbe, S., Broderick, P., Chandler, I., Pittman, A., Penegar, S., Campbell, H., Tomlinson, I. & Houlston, R. S., Jun 2013, In : Gut. 62, 6, p. 871-881 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  237. Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients

    Tanskanen, T., Gylfe, A. E., Katainen, R., Taipale, M., Renkonen-Sinisalo, L., Mecklin, J-P., Järvinen, H., Tuupanen, S., Kilpivaara, O., Vahteristo, P. & Aaltonen, L. A., Jun 2013, In : Scandinavian Journal of Gastroenterology. 48, 6, p. 672-678 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  238. Prevalence of Germline PTEN, BMPR1A, SMAD4, STK11, and ENG Mutations in Patients With Moderate- Load Colorectal Polyps

    Ngeow, J., Heald, B., Rybicki, L. A., Orloff, M. S., Chen, J. L., Liu, X., Yerian, L., Willis, J., Lehtonen, H. J., Lehtonen, R., Mester, J. L., Moline, J., Burke, C. A., Church, J., Aaltonen, L. A. & Eng, C., Jun 2013, In : Gastroenterology. 144, 7, p. 1402-U149 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  239. Characterization of Uterine Leiomyomas by Whole-Genome Sequencing

    Mehine, M., Kaasinen, E., Mäkinen, N., Katainen, R., Kämpjärvi, K., Pitkänen, E., Heinonen, H-R., Butzow, R., Kilpivaara, O., Kuosmanen, A., Ristolainen, H., Gentile, M., Sjöberg, J., Vahteristo, P. & Aaltonen, L. A., 4 Jul 2013, In : New England Journal of Medicine. 369, 1, p. 43-53 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  240. Lessons from Functional Analysis of Genome-Wide Association Studies

    Sur, I., Tuupanen, S., Whitington, T., Aaltonen, L. A. & Taipale, J., 15 Jul 2013, In : Cancer Research. 73, 14, p. 4180-4184 5 p.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  241. Eleven Candidate Susceptibility Genes for Common Familial Colorectal Cancer

    Gylfe, A. E., Katainen, R., Kondelin, J., Tanskanen, T., Cajuso Pons, T., Hänninen, U., Taipale, J., Taipale, M., Renkonen-Sinisalo, L., Järvinen, H., Mecklin, J-P., Kilpivaara, O., Pitkänen, E., Vahteristo, P., Tuupanen, S., Karhu, A. & Aaltonen, L. A., 18 Oct 2013, In : PLoS Genetics. 9, 10, 8 p., e1003876.

    Research output: Contribution to journalArticleScientificpeer-review

  242. MED12 exon 2 mutations in histopathological uterine leiomyoma variants

    Mäkinen, N., Vahteristo, P., Kämpjärvi, K., Arola, J., Butzow, R. & Aaltonen, L. A., Nov 2013, In : European Journal of Human Genetics. 21, 11, p. 1300-1303 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  243. Chromothripsis in Uterine Leiomyomas Reply

    Mehine, M., Kaasinen, E. & Aaltonen, L. A., 28 Nov 2013, In : New England Journal of Medicine. 369, 22, p. 2160-2161 2 p.

    Research output: Contribution to journalArticleScientific

  244. 2014
  245. Frequent L1 retrotranspositions originating from TTC28 in colorectal cancer

    Pitkanen, E., Cajuso Pons, T., Katainen, R., Kaasinen, E., Valimaki, N., Palin, K., Taipale, J., Aaltonen, L. A. & Kilpivaara, O., 2014, In : Oncotarget. 5, 3, p. 853-859 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  246. Exomic landscape of MED12 mutation-negative and -positive uterine leiomyomas

    Mäkinen, N., Vahteristo, P., Butzow, R., Sjoberg, J. & Aaltonen, L. A., 1 Feb 2014, In : International Journal of Cancer. 134, 4, p. 1008-1012 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  247. Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas

    Mäkinen, N., Heinonen, H-R., Sjoberg, J., Taipale, J., Vahteristo, P. & Aaltonen, L. A., 29 Apr 2014, In : British Journal of Cancer. 110, 9, p. 2246-2249 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  248. Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity

    Turunen, M., Spaeth, J. M., Keskitalo, S., Park, M. J., Kivioja, T., Clark, A. D., Mäkinen, N., Gao, F., Palin, K., Nurkkala, H., Vaharautio, A., Aavikko, M., Kampjarvi, K., Vahteristo, P., Kim, C. A., Aaltonen, L. A., Varjosalo, M., Taipale, J. & Boyer, T. G., May 2014, In : Cell Reports. 7, 3, p. 654-660 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  249. Genomics of uterine leiomyomas: insights from high-throughput sequencing

    Mehine, M., Makinen, N., Heinonen, H-R., Aaltonen, L. A. & Vahteristo, P., Sep 2014, In : Fertility and Sterility : official journal of the American Fertility Society . 102, 3, p. 621-629 9 p.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  250. Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

    Knappskog, S., Gansmo, L. B., Dibirova, K., Metspalu, A., Cybulski, C., Peterlongo, P., Aaltonen, L., Vatten, L., Romundstad, P., Hveem, K., Devilee, P., Evans, G. D., Lin, D., Van Camp, G., Manolopoulos, V. G., Osorio, A., Milani, L., Ozcelik, T., Zalloua, P., Mouzaya, F. & 17 othersBliznetz, E., Balanovska, E., Pocheshkova, E., Kucinskas, V., Atramentova, L., Nymadawa, P., Titov, K., Lavryashina, M., Yusupov, Y., Bogdanova, N., Koshel, S., Zamora, J., Wedge, D. C., Charlesworth, D., Doerk, T., Balanovsky, O. & Lonning, P. E., 30 Sep 2014, In : Oncotarget. 5, 18, p. 8223-8234 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

  251. Clinical characterization, genetic mapping and whole- genome sequence analysis of a novel autosomal recessive intellectual disability syndrome

    Kaasinen, E., Rahikkala, E., Koivunen, P., Miettinen, S., Wamelink, M. M. C., Aavikko, M., Palin, K., Myllyharju, J., Moilanen, J. S., Pajunen, L., Karhu, A. & Aaltonen, L. A., Oct 2014, In : European Journal of Medical Genetics. 57, 10, p. 543-551 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  252. MED12 mutation frequency in unselected sporadic uterine leiomyomas

    Heinonen, H-R., Sarvilinna, N. S., Sjoberg, J., Kampjarvi, K., Pitkanen, E., Vahteristo, P., Makinen, N. & Aaltonen, L. A., Oct 2014, In : Fertility and Sterility : official journal of the American Fertility Society . 102, 4, p. 1137-1142 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  253. Identification of 33 candidate oncogenes by screening for base-specific mutations

    Tuupanen, S., Hanninen, U. A., Kondelin, J., von Nandelstadh, P., Cajuso, T., Gylfe, A. E., Katainen, R., Tanskanen, T., Ristolainen, H., Bohm, J., Mecklin, J-P., Järvinen, H., Renkonen-Sinisalo, L., Andersen, C. L., Taipale, M., Taipale, J., Vahteristo, P., Lehti, K., Pitkanen, E. & Aaltonen, L. A., 14 Oct 2014, In : British Journal of Cancer. 111, 8, p. 1657-1662 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  254. High Frequency of RPL22 Mutations in Microsatellite-Unstable Colorectal and Endometrial Tumors

    Ferreira, A. M., Tuominen, I., van Dijk-Bos, K., Sanjabi, B., van der Sluis, T., van der Zee, A. G., Hollema, H., Zazula, M., Sijmons, R. H., Aaltonen, L. A., Westers, H. & Hofstra, R. M. W., Dec 2014, In : Human Mutation. 35, 12, p. 1442-1445 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  255. New Target Genes in Endometrial Tumors Show a Role for the Estrogen-Receptor Pathway in Microsatellite-Unstable Cancers

    Ferreira, A. M., Tuominen, I., Sousa, S., Gerbens, F., van Dijk-Bos, K., Osinga, J., Kooi, K. A., Sanjabi, B., Esendam, C., Oliveira, C., Terpstra, P., Hardonk, M., van der Sluis, T., Zazula, M., Stachura, J., van der Zee, A. G., Hollema, H., Sijmons, R. H., Aaltonen, L. A., Seruca, R. & 2 othersHofstra, R. M. W. & Westers, H., Dec 2014, In : Human Mutation. 35, 12, p. 1514-1523 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  256. Identification of Novel Germline Variants in Early-Onset Familial Classical Hodgkin Lymphoma with Exome Sequencing

    Kilpivaara, O., Ristolainen, H., Kamper, P., Taskinen, M., Saarinen, S., Leppa, S., d'Amore, F. & Lauri, A. A., 6 Dec 2014, In : Blood. 124, 21, p. 4402 3 p.

    Research output: Contribution to journalMeeting AbstractResearchpeer-review

  257. 2015
  258. Systematic search for rare variants in Finnish early-onset colorectal cancer patients

    Tanskanen, T., Gylfe, A. E., Katainen, R., Taipale, M., Renkonen-Sinisalo, L., Järvinen, H., Mecklin, J-P., Bohm, J., Kilpivaara, O., Pitkanen, E., Palin, K., Vahteristo, P., Tuupanen, S. & Aaltonen, L. A., 2015, In : Cancer Genetics. 208, 1-2, p. 35-U100 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  259. Whole-Genome Sequencing of Growth Hormone (GH) - secreting Pituitary Adenomas

    Välimäki, N., Demir, H., Pitkänen, E. A., Kaasinen, E., Karppinen, A., Kivipelto, L. J., Schalin-Jäntti, C. B. M., Aaltonen, L. A. & Karhu, A. I., 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 10, p. 3918-3927 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  260. Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry

    Nummela, P., Saarinen, L., Thiel, A., Järvinen, P., Lehtonen, R., Lepisto, A., Järvinen, H., Aaltonen, L. A., Hautaniemi, S. & Ristimaki, A., 1 Mar 2015, In : International Journal of Cancer. 136, 5, p. E282-E289 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  261. Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer

    Donner, I., Kiviluoto, T., Ristimaki, A., Aaltonen, L. A. & Vahteristo, P., Jun 2015, In : Familial Cancer. 14, 2, p. 241-246 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  262. Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma

    Aavikko, M., Kaasinen, E., Nieminen, J. K., Byun, M., Donner, I., Mancuso, R., Ferrante, P., Clerici, M., Brambilla, L., Tourlaki, A., Sarid, R., Guttman-Yassky, E., Taipale, M., Morgunova, E., Pekkonen, P., Ojala, P. M., Pukkala, E., Casanova, J-L., Vaarala, O., Vahteristo, P. & 1 othersAaltonen, L. A., 1 Jun 2015, In : Journal of Infectious Diseases. 211, 11, p. 1842-1851 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  263. CTCF/cohesin-binding sites are frequently mutated in cancer

    Katainen, R., Dave, K., Pitkänen, E., Palin, K., Kivioja, T., Valimaki, N., Gylfe, A. E., Ristolainen, H., Hanninen, U. A., Cajuso, T., Kondelin, J., Tanskanen, T., Mecklin, J-P., Järvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Kaasinen, E., Kilpivaara, O., Tuupanen, S., Enge, M. & 2 othersTaipale, J. & Aaltonen, L. A., 1 Jul 2015, In : Nature Genetics. 47, 7, p. 818-+

    Research output: Contribution to journalArticleScientificpeer-review

  264. Identification of homozygous deletion in ACAN and other candidate variants in familial classical Hodgkin lymphoma by exome sequencing

    Ristolainen, H., Kilpivaara, O., Kamper, P., Taskinen, M., Saarinen, S., Leppa, S., d'Amore, F. & Aaltonen, L. A., Aug 2015, In : British Journal of Haematology. 170, 3, p. 428-431 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  265. Clonally related uterine leiomyomas are common and display branched tumor evolution

    Mehine, M., Heinonen, H-R., Sarvilinna, N., Pitkanen, E., Makinen, N., Katainen, R., Tuupanen, S., Butzow, R., Sjoberg, J. & Aaltonen, L. A., 1 Aug 2015, In : Human Molecular Genetics. 24, 15, p. 4407-4416 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  266. 3 '-UTR poly(T/U) repeat of EWSR1 is altered in microsatellite unstable colorectal cancer with nearly perfect sensitivity

    Kondelin, J., Tuupanen, S., Gylfe, A. E., Aavikko, M., Renkonen-Sinisalo, L., Järvinen, H., Bohm, J., Mecklin, J-P., Andersen, C. L., Vahteristo, P., Pitkanen, E. & Aaltonen, L. A., Sep 2015, In : Familial Cancer. 14, 3, p. 449-453 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  267. 2016
  268. Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers

    Mehine, M., Kaasinen, E., Heinonen, H-R., Makinen, N., Kampjarvi, K., Sarvilinna, N., Aavikko, M., Vaharautio, A., Pasanen, A., Butzow, R., Heikinheimo, O., Sjoberg, J., Pitkanen, E., Vahteristo, P. & Aaltonen, L. A., 2 Feb 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. 1315-1320 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  269. Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease

    Orlando, G., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Kaprio, J., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A. & 37 othersJärvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Tenesa, A., Farrington, S., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J., Jenkins, M., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Taipale, J., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P., Aaltonen, L. A. & Houlston, R. S., 1 Jun 2016, In : Human Molecular Genetics. 25, 11, p. 2349-2359 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  270. MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas

    Kampjarvi, K., Makinen, N., Mehine, M., Valipakka, S., Uimari, O., Pitkanen, E., Heinonen, H-R., Heikkinen, T., Tolvanen, J., Ahtikoski, A., Frizzell, N., Sarvilinna, N., Sjoberg, J., Butzow, R., Aaltonen, L. A. & Vahteristo, P., 14 Jun 2016, In : British Journal of Cancer. 114, 12, p. 1405-1411 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  271. Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer

    Jarvis, D., Mitchell, J. S., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Kaprio, J., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S. & 37 othersPalotie, A., Järvinen, H., Renkonen-Sinisalo, L., Lepistö, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Taipale, J., Aaltonen, L. A., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P. & Houlston, R. S., 12 Jul 2016, In : British Journal of Cancer. 115, 2, p. 266-272 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  272. 2017
  273. Multiple components of PKA and TGF-beta pathways are mutated in pseudomyxoma peritonei

    Saarinen, L., Nummela, P., Thiel, A., Lehtonen, R., Järvinen, P., Järvinen, H., Aaltonen, L. A., Lepisto, A., Hautaniemi, S. & Ristimaki, A., 20 Apr 2017, In : PLoS One. 12, 4, 16 p., 0174898.

    Research output: Contribution to journalArticleScientificpeer-review

  274. Whole-exome sequencing identifies novel candidate predisposition genes for familial polycythemia vera

    Hirvonen, E. A. M., Pitkanen, E., Hemminki, K., Aaltonen, L. A. & Kilpivaara, O., 20 Apr 2017, In : Human Genomics. 11, 6 p., 6.

    Research output: Contribution to journalArticleScientificpeer-review

  275. Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas

    Heinonen, H-R., Pasanen, A., Heikinheimo, O., Tanskanen, T., Palin, K., Tolvanen, J., Vahteristo, P., Sjoberg, J., Pitkänen, E., Butzow, R., Makinen, N. & Aaltonen, L. A., 21 Apr 2017, In : Scientific Reports. 7, 7 p., 1015.

    Research output: Contribution to journalArticleScientificpeer-review

  276. Candidate susceptibility variants for esophageal squamous cell carcinoma

    Donner, I., Katainen, R., Tanskanen, T., Kaasinen, E., Aavikko, M., Ovaska, K., Artama, M., Pukkala, E. & Aaltonen, L. A., Jun 2017, In : Genes, Chromosomes & Cancer. 56, 6, p. 453-459 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  277. Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

    Rodriguez-Broadbent, H., Law, P. J., Sud, A., Palin, K., Tuupanen, S., Gylfe, A., Hanninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Ripatti, S., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Palotie, A. & 36 othersRenkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Passarelli, M. N., Figueiredo, J. C., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Aaltonen, L. A., Cheadle, J. P., Tomlinson, I. P., Dunlop, M. G. & Houlston, R. S., 15 Jun 2017, In : International Journal of Cancer. 140, 12, p. 2701-2708 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  278. Comprehensive Evaluation of Protein Coding Mononucleotide Microsatellites in Microsatellite-Unstable Colorectal Cancer

    Kondelin, J., Gylfe, A. E., Lundgren, S., Tanskanen, T., Hamberg, J., Aavikko, M., Palin, K., Ristolainen, H., Katainen, R., Kaasinen, E., Taipale, M., Taipale, J., Renkonen-Sinisalo, L., Jarvinen, H., Bohm, J., Mecklin, J-P., Vahteristo, P., Tuupanen, S., Aaltonen, L. A. & Pitkanen, E., 1 Aug 2017, In : Cancer Research. 77, 15, p. 4078-4088 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  279. Germline MSH6 Mutation in a Patient With Two Independent Primary Glioblastomas

    Forsstrom, L. M., Sumi, K., Makinen, M. J., Oh, J. E., Herva, R., Kleihues, P., Ohgaki, H. & Aaltonen, L. A., Oct 2017, In : Journal of Neuropathology and Experimental Neurology. 76, 10, p. 848-853 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  280. Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis

    May-Wilson, S., Sud, A., Law, P. J., Palin, K., Tuupanen, S., Gylfe, A., Hänninen, U. A., Cajuso, T., Tanskanen, T., Kondelin, J., Kaasinen, E., Sarin, A-P., Eriksson, J. G., Rissanen, H., Knekt, P., Pukkala, E., Jousilahti, P., Salomaa, V., Ripatti, S., Palotie, A. & 34 othersRenkonen-Sinisalo, L., Lepisto, A., Böhm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Fisher, D., Kerr, R., Kerr, D., Passarelli, M. N., Figueiredo, J. C., Buchanan, D. D., Win, A. K., Hopper, J. L., Jenkins, M. A., Lindor, N. M., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F., Casey, G., Aaltonen, L. A., Cheadle, J. P., Tomlinson, I. P., Dunlop, M. G. & Houlston, R. S., Oct 2017, In : European Journal of Cancer. 84, p. 228-238 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  281. Detection of subclonal L1 transductions in colorectal cancer by long-distance inverse-PCR and Nanopore sequencing

    Pradhan, B., Cajuso, T., Katainen, R., Sulo, P., Tanskanen, T., Kilpivaara, O., Pitkanen, E., Aaltonen, L. A., Kauppi, L. & Palin, K., 6 Nov 2017, In : Scientific Reports. 7, 12 p., 14521.

    Research output: Contribution to journalArticleScientificpeer-review

  282. Global metabolomic profiling of uterine leiomyomas

    Heinonen, H-R., Mehine, M., Mäkinen, N., Pasanen, A., Pitkänen, E., Karhu, A., Sarvilinna, N. S., Sjöberg, J., Heikinheimo, O., Bützow, R., Aaltonen, L. A. & Kaasinen, E., 5 Dec 2017, In : British Journal of Cancer. 117, 12, p. 1855-1864 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  283. 2018
  284. Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci

    Tanskanen, T., van den Berg, L., Valimaki, N., Aavikko, M., Ness-Jensen, E., Hveem, K., Wettergren, Y., Lindskog, E. B., Tonisson, N., Metspalu, A., Silander, K., Orlando, G., Law, P. J., Tuupanen, S., Gylfe, A. E., Hanninen, U. A., Cajuso, T., Kondelin, J., Sarin, A-P., Pukkala, E. & 40 othersJousilahti, P., Salomaa, V., Ripatti, S., Palotie, A., Jarvinen, H., Renkonen-Sinisalo, L., Lepisto, A., Bohm, J., Mecklin, J-P., Al-Tassan, N. A., Palles, C., Martin, L., Barclay, E., Tenesa, A., Farrington, S. M., Timofeeva, M. N., Meyer, B. F., Wakil, S. M., Campbell, H., Smith, C. G., Idziaszczyk, S., Maughan, T. S., Kaplan, R., Kerr, R., Kerr, D., Buchanan, D. D., Win, A. K., Hopper, J., Jenkins, M. A., Newcomb, P. A., Gallinger, S., Conti, D., Schumacher, F. R., Casey, G., Cheadle, J. P., Dunlop, M. G., Tomlinson, I. P., Houlston, R. S., Palin, K. & Aaltonen, L. A., 1 Feb 2018, In : International Journal of Cancer. 142, 3, p. 540-546 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  285. Exome-wide somatic mutation characterization of small bowel adenocarcinoma

    Hänninen, U. A., Katainen, R., Tanskanen, T., Plaketti, R-M., Laine, R., Hamberg, J., Ristimäki, A., Pukkala, E., Taipale, M., Mecklin, J-P., Forsström, L. M., Pitkänen, E., Palin, K., Välimäki, N., Mäkinen, N. & Aaltonen, L. A., Mar 2018, In : PLoS Genetics. 14, 3, 23 p., 1007200.

    Research output: Contribution to journalArticleScientificpeer-review

  286. Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

    Park, M. J., Shen, H., Spaeth, J. M., Tolvanen, J. H., Failor, C., Knudtson, J. F., McLaughlin, J., Halder, S. K., Yang, Q., Bulun, S. E., Al-Hendy, A., Schenken, R. S., Aaltonen, L. A. & Boyer, T. G., 30 Mar 2018, In : Journal of Biological Chemistry. 293, 13, p. 4870-4882 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

  287. Germline mutations in young non-smoking women with lung adenocarcinoma

    Donner, I., Katainen, R., Sipilä, L. J., Aavikko, M., Pukkala, E. & Aaltonen, L. A., Aug 2018, In : Lung Cancer. 122, p. 76-82 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  288. Contribution of allelic imbalance to colorectal cancer

    Palin, K., Pitkänen, E., Turunen, M., Sahu, B., Pihlajamaa, P., Kivioja, T., Kaasinen, E., Välimäki, N., Hänninen, U. A., Cajuso, T., Aavikko, M., Tuupanen, S., Kilpivaara, O., van den Berg, L., Kondelin, J., Tanskanen, T., Katainen, R., Grau, M., Rauanheimo, H., Plaketti, R-M. & 20 othersTaira, A., Sulo, P., Hartonen, T., Dave, K., Schmierer, B., Botla, S., Sokolova, M., Vähärautio, A., Gladysz, K., Ongen, H., Dermitzakis, E., Bramsen, J. B., Orntoft, T. F., Andersen, C. L., Ristimäki, A., Lepistö, A., Renkonen-Sinisalo, L., Mecklin, J-P., Taipale, J. & Aaltonen, L. A., 10 Sep 2018, In : Nature Communications. 9, 9 p., 3664.

    Research output: Contribution to journalArticleScientificpeer-review

  289. Discovery of potential causative mutations in human coding and noncoding genome with the interactive software BasePlayer

    Katainen, R., Donner, I., Cajuso, T., Kaasinen, E., Palin, K., Mäkinen, V., Aaltonen, L. A. & Pitkänen, E., Nov 2018, In : Nature Protocols. 13, 11, p. 2580-2600 21 p.

    Research output: Contribution to journalArticleScientificpeer-review

  290. 2019
  291. Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma

    Donner, I., Katainen, R., Kaasinen, E., Aavikko, M., Sipilä, L. J., Pukkala, E. & Aaltonen, L. A., Jan 2019, In : Familial Cancer. 18, 1, p. 113-119 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  292. Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans

    Kaasinen, E., Kuismin, O., Rajamäki, K., Ristolainen, H., Aavikko, M., Kondelin, J., Saarinen, S., Berta, D. G., Katainen, R., Hirvonen, E. A. M., Karhu, A., Taira, A., Tanskanen, T., Alkodsi, A., Taipale, M., Morgunova, E., Franssila, K., Lehtonen, R., Mäkinen, M., Aittomäki, K. & 15 othersPalotie, A., Kurki, M., Pietiläinen, O., Hilpert, M., Saarentaus, E., Niinimäki, J., Junttila, J., Kaikkonen, K., Vahteristo, P., Skoda, R. C., Seppänen, M. R. J., Eklund, K. K., Taipale, J., Kilpivaara, O. & Aaltonen, L. A., 19 Mar 2019, In : Nature Communications. 10, 17 p., 1252.

    Research output: Contribution to journalArticleScientificpeer-review

  293. Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

    Hanninen, U. A., Wirta, E-V., Katainen, R., Tanskanen, T., Hamberg, J., Taipale, M., Böhm, J., Renkonen-Sinisalo, L., Lepistö, A., Forsström, L. M., Pitkänen, E., Palin, K., Seppälä, T. T., Mäkinen, N., Mecklin, J-P. & Aaltonen, L. A., 30 Apr 2019, In : British Journal of Cancer. 120, 9, p. 922-930 9 p.

    Research output: Contribution to journalArticleScientificpeer-review