Matjaz Barboric

Person

    Research areas

  • 118 Biological sciences - gene expression, transcription elongation, P-TEFb, 7SK snRNP, pre-mRNA splicing, HIV-1 gene regulation

Description of research and teaching

Controlling Transcription Elongation by RNA polymerase II: mechanisms, disease and development

We are investigating the fundamental mechanisms of metazoan gene transcription by RNA polymerase II (RNAPII). In particular, we are studying the regulatory factors that modulate RNAPII transcription at the level of elongation, which has been recognized only recently as a major rate-limiting step in gene expression. Our work is focused mainly on the key cyclin-dependent kinases that stimulate RNAPII elongation and phosphorylate the C-terminal domain of the biggest subunit of RNAPII, Rbp1, at serine 2 (Ser2-P CTD). By using biochemistry, genetics and the tools of systems biology, we are aiming to understand mechanisms that enable the function of elongation kinases as well as biological processes that are controlled by them. Because transcription elongation can be intimately connected to pre-mRNA processing in the course of transcription via Ser2-P CTD, we are also studying how elongation kinases affect mRNA maturation events such as alternative splicing. Of note, an important aspect of our work is to uncover how deregulation of RNAPII elongation control contributes to the onset of deadly diseases, including cancer. Finally, revealing the significance of transcription elongation kinases in embryonic development remains a pressing issue in our research group.

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Curriculum Vitae

Latest publications

  1. Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

    Anastasina, M., Le May, N., Bugai, A., Fu, Y., Soderholm, S., Gaelings, L., Ohman, T., Tynell, J., Kyttanen, S., Barboric, M., Nyman, T. A., Matikainen, S., Julkunen, I., Butcher, S. J., Egly, J-M. & Kainov, D. E. Nov 2016 In : Biochimica et Biophysica Acta. Gene Regulatory Mechanisms. 1859, 11, p. 1440-1448 9 p.

    Publication: Contribution to journalA1 Refereed journal article

  2. Cracking the control of RNA polymerase II elongation by 7SK snRNP and P-TEFb

    Christiano Quaresma, A. J., Bugai, A. & Barboric, M. 19 Sep 2016 In : Nucleic Acids Research. 44, 16, p. 7527-7539 13 p.

    Publication: Contribution to journalA1 Refereed journal article

  3. The two sides of Tat

    Barboric, M. & Fujinaga, K. 19 Jan 2016 In : eLife. 5, 3 p., 12686

    Publication: Contribution to journalB1 Unrefereed journal article

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Latest projects

  1. Sigrid Juseliuksen Säätiö/Barboric Matjaz 2011

    Barboric, M.

    Unknown funder

    01/06/201130/04/2014

    Project: Research project

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Education

Muu tai tuntematon koulutus, koulutusaste tuntemat

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