Osamu Shimmi


Description of research and teaching

Research summary: A key issue in biology is to uncover the mechanisms employed by conserved signaling pathways to generate morphological diversity. The Bone Morphogenetic Proteins (BMPs), members of the TGF-beta superfamily, are a family of highly conserved secreted growth factors involved in metazoan developmental processes as diverse as cell proliferation, apoptosis, differentiation and cell-fate determination. Our studies intend to unveil the mechanisms of how spatial distribution of BMP ligands is regulated for pattern formation and how its modifications contribute to morphological variations in Drosophila and other species.

Teaching: Advanced developmental biology, Stem cells and organogenesis, Developmental biology practical course


Latest publications

  1. The molecular and cellular mechanisms coupling epithelial morphogenesis and developmental signalling

    Toddie-Moore, D., Marin-Riera, M., Salazar-Ciudad, I. & Shimmi, O. Jul 2017 In : Mechanisms of Development. 145, p. S94-S94 1 p.

    Research output: Research - peer-reviewMeeting Abstract

  2. Scribbled Optimizes BMP Signaling through its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis

    Gui, J., Huang, Y. & Shimmi, O. 4 Nov 2016 In : PLoS Genetics. 12, 11, 19 p., e1006424

    Research output: Scientific - peer-reviewArticle

  3. Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints

    Tauscher, P., Gui, J. & Shimmi, O. 18 Oct 2016 In : Development. 143, 20, p. 3742-3750 9 p.

    Research output: Scientific - peer-reviewArticle

View all (22) »

Latest activities

  1. Cell shape changes couple wing vein morphogenesis with BMP signalling

    Daniel John Toddie-Moore (Speaker), Shimmi, O. (Speaker)
    23 Sep 2017

    Activity: Talk or presentationOral presentation

  2. Mechanisms of Development (Journal)

    Shimmi, O. (Reviewer)
    11 Sep 201718 Sep 2017

    Activity: Publication peer-review and editorial workPeer review of manuscripts

View all (80) »


Fil. toht., biotieteet, biokemia

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