Osamu Shimmi


Description of research and teaching

Research summary: A key issue in biology is to uncover the mechanisms employed by conserved signaling pathways to generate morphological diversity. The Bone Morphogenetic Proteins (BMPs), members of the TGF-beta superfamily, are a family of highly conserved secreted growth factors involved in metazoan developmental processes as diverse as cell proliferation, apoptosis, differentiation and cell-fate determination. Our studies intend to unveil the mechanisms of how spatial distribution of BMP ligands is regulated for pattern formation and how its modifications contribute to morphological variations in Drosophila and other species.

Teaching: Advanced developmental biology, Stem cells and organogenesis, Developmental biology practical course


Latest publications

  1. Wing vein development in the sawfly Athalia rosae is regulated by spatial transcription of Dpp/BMP signaling components

    Huang, Y., Hatakeyama, M. & Shimmi, O. 2018 In : Arthropod Structure & Development.

    Research output: Contribution to journalArticle

  2. The molecular and cellular mechanisms coupling epithelial morphogenesis and developmental signalling

    Toddie-Moore, D., Marin-Riera, M., Salazar-Ciudad, I. & Shimmi, O. Jul 2017 In : Mechanisms of Development. 145, p. S94-S94 1 p.

    Research output: Contribution to journalMeeting Abstract

  3. Scribbled Optimizes BMP Signaling through its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis

    Gui, J., Huang, Y. & Shimmi, O. 4 Nov 2016 In : PLoS Genetics. 12, 11, 19 p., e1006424

    Research output: Contribution to journalArticle

View all (23) »

Latest activities

  1. Arthropod Structure & Development (Journal)

    Shimmi, O. (Reviewer)
    12 Apr 20182 May 2018

    Activity: Publication peer-review and editorial workPeer review of manuscripts

  2. Dynamic 3D tissue architecture directs BMP morphogen signaling during Drosophila wing morphogenesis

    Kracklauer, M. (Speaker), Shimmi, O. (Speaker)
    11 Apr 201815 Apr 2018

    Activity: Talk or presentationOral presentation

  3. Oncogene (Journal)

    Shimmi, O. (Reviewer)
    11 Feb 201828 Feb 2018

    Activity: Publication peer-review and editorial workPeer review of manuscripts

View all (85) »


Fil. toht., biotieteet, biokemia

ID: 24883