Osamu Shimmi


Description of research and teaching

Research summary: A key issue in biology is to uncover the mechanisms employed by conserved signaling pathways to generate morphological diversity. The Bone Morphogenetic Proteins (BMPs), members of the TGF-beta superfamily, are a family of highly conserved secreted growth factors involved in metazoan developmental processes as diverse as cell proliferation, apoptosis, differentiation and cell-fate determination. Our studies intend to unveil the mechanisms of how spatial distribution of BMP ligands is regulated for pattern formation and how its modifications contribute to morphological variations in Drosophila and other species.

Teaching: Advanced developmental biology, Stem cells and organogenesis, Developmental biology practical course


Latest publications

  1. Scribbled Optimizes BMP Signaling through its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis

    Gui, J., Huang, Y. & Shimmi, O. 4 Nov 2016 In : PLoS Genetics. 12, 11, 19 p., e1006424

    Research output: Scientific - peer-reviewArticle

  2. Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints

    Tauscher, P., Gui, J. & Shimmi, O. 18 Oct 2016 In : Development. 143, 20, p. 3742-3750 9 p.

    Research output: Scientific - peer-reviewArticle

  3. lolal Is an Evolutionarily New Epigenetic Regulator of dpp Transcription during Dorsal-Ventral Axis Formation

    Quijano, J. C., Wisotzkey, R. G., Tran, . N. L., Huang, Y., Stinchfield, M. J., Haerry, . T. E., Shimmi, O. & Newfeld, . S. J. 8 Jul 2016 In : Molecular Biology and Evolution. 33, 10, p. 2621-2632

    Research output: Scientific - peer-reviewArticle

View all (21) »

Latest activities

  1. Mechanisms of Development (Journal)

    Shimmi, O. (Reviewer)
    11 Sep 201718 Sep 2017

    Activity: Publication peer-review and editorial workPeer review of manuscripts

  2. Invited seminar

    Shimmi, O. (Participant)
    18 May 2017

    Activity: OtherTypes for other activities - Other

  3. Invited seminar

    Shimmi, O. (Participant)
    17 May 2017

    Activity: OtherTypes for other activities - Other

View all (77) »


Fil. toht., biotieteet, biokemia

ID: 24883