Sanna Lehtonen


Description of research and teaching

Diabetic nephropathy, the serious renal complication of diabetes, starts with albuminuria and can lead to end stage renal disease. Insulin resistance is associated with an increased risk for the development of diabetic nephropathy. Interestingly, the glomerular epithelial cells or podocytes have recently been shown to be insulin responsive and to increase their glucose uptake upon insulin stimulation. It has also been shown that filamentous actin cytoskeleton is required for the insulin response and further, nephrin, a key structural component of podocytes, is essential for insulin action in these cells. Our group aims to characterize the pathophysiological mechanims involved in the early stages of diabetic nephropathy and the development of albuminuria. Specifically, we are interested in analyzing the role of insulin signaling and glucose transport and the regulation of actin cytoskeleton in podocytes.

Further information on the affiliationMedicum, Department of Pathology

Latest publications

  1. Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

    Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P-H., Wähälä, K., Tienari, J. & Lehtonen, S., Feb 2019, In : FASEB Journal. 33, 2, p. 2858-2869 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

  2. Glucose Transporters in Diabetic Kidney Disease-Friends or Foes?

    Wasik, A. A. & Lehtonen, S., 9 Apr 2018, In : Frontiers in Endocrinology. 9, 12 p., 155.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  3. Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

    Saurus, P., Tolvanen, T. A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E. & Lehtonen, S., 6 Sep 2017, In : Scientific Reports. 7, 14 p., 10731.

    Research output: Contribution to journalArticleScientificpeer-review

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Latest activities

  1. Amr Elseragy's thesis supervisory board member

    Sanna Lehtonen (Supervisor)
    2019 → …

    Activity: Examination typesMember of doctoral thesis committee / follow-up group

  2. The Paulo Foundation (External organisation)

    Sanna Lehtonen (Board member)
    2019 → …

    Activity: Membership typesMembership or other role in national/international committee, council, board

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Latest projects

  1. SHIBNESS: Business from SHIP2 inhibitors TEKES

    Lehtonen, S. & Wähälä, K.


    Project: Research project

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ID: 70682