Tapani Viitala

Person

    Research areas

  • 317 Pharmacy - Pharmaceutical nanotechnology, Cell model membranes, Targeted drug and gene delivery, Physico-Chemical proerties of drugs, In vitro drug discovery and development methods
  • 221 Nano-technology - Organic thin films, Ultrathin organic films, Self-assembled monolayers, Lipid bilayers, Liposomes, Nanoparticles, Langmuir- and Langmuir-Blodgett technologies
  • 116 Chemical sciences - Physical Chemistry, Surface and Colloid Chemistry, Physico-Chemical characterisation, Surface specific analysis methods, Quartz crystal microbalance, Surface plasmon resonance spectroscopy, Spectroscopy, Contact angle, Surface tension, Surface energy, Surface active agents

Description of research and teaching

Adjunct professor in pharmaceutical surface chemistry and biophysics.

I am the co-group leader of the Pharmaceutical Biophysics research group at the Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Finland (UH). The Pharmaceutical Biophysics research group develops and uses powerful new hybrid experimental-computational tools to gain mechanistic understanding of the key intermolecular interactions involved in drug action and delivery. A special interest of mine is to develop novel real-time label-free experimental in vitro platforms as complementary tools for existing static biological assays and animal tests in the field of preclinical drug research and drug discovery. I primarily use the multi-parametric surface plasmon resonance (MP-SPR) and impedance-based quartz crystal microbalance techniques (QCM-Z) as detection platforms in my research. I had a 5 year Academy Research Fellow position in 2010-2015 and have 10 years work experience from surface chemistry instrument manufacturing industry (2000-2010).
My research group is part of the Drug Research Program at the Faculty of Pharmacy at University of Helsinki and I collaborate with departments from several national and international universities (e.g. Åbo Akademi, Aalto University, Tampere University of Technology, Padova University and University of Montreal) and companies (e.g. Bionavis Ltd, Biolin Scientific Oy and Accurion GmbH).
I am lecturing in the basic course in Pharmacokinetics, and advanced courses in Physical Pharmacy and Introduction to Nanosciences. I integrate my research into teaching by supervising master´s and PhD students within my research focus areas.

Description of research and teaching

Adjunct Professor

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Highlighted publications

  1. Real-Time Label-Free Monitoring of Nanoparticle Cell Uptake

    Suutari, T., Silen, T., Sen Karaman, D., Saari, H., Desai, D., Kerkelä, E., Laitinen, S., Hanzlikova, M., Rosenholm, J. M., Yliperttula, M. & Viitala, T. 7 Dec 2016 In : Small. 12, 45, p. 6289-6300 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

  2. Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier

    Baghirov, H., Karaman, D., Viitala, T., Duchanoy, A., Lou, Y-R., Mamaeva, V., Pryazhnikov, E., Khiroug, L., Davies, C. D. L., Sahlgren, C. & Rosenholm, J. M. 22 Aug 2016 In : PLoS One. 11, 8, 22 p., 0160705

    Research output: Contribution to journalArticleScientificpeer-review

  3. Rational design of liposomal drug delivery systems, a review: Combined experimental and computational studies of lipid membranes, liposomes and their PEGylation

    Bunker, A., Magarkar, A. & Viitala, T. Oct 2016 In : Biochimica et Biophysica Acta. Biomembranes. 1858, 10, p. 2334-2352 19 p.

    Research output: Contribution to journalArticleScientificpeer-review

  4. Elucidating the Signal Responses of Multi-Parametric Surface Plasmon Resonance Living Cell Sensing: A Comparison between Optical Modeling and Drug-MDCKII Cell Interaction Measurements

    Viitala, T., Granqvist, N., Hallila, S., Ravina , M. & Yliperttula, M. 27 Aug 2013 In : PLoS One. 8, 8, 13 p., 72192

    Research output: Contribution to journalArticleScientificpeer-review

  5. Printing technologies in fabrication of drug delivery systems

    Kolakovic, R., Viitala, T., Ihalainen, P., Genina, N., Peltonen, J. & Sandler, N. Dec 2013 In : Expert Opinion on Drug Delivery. 10, 12, p. 1711-1723 13 p.

    Research output: Contribution to journalReview ArticleScientificpeer-review

  6. Fluid dynamics modeling for synchronizing surface plasmon resonance and quartz crystal microbalance as tools for biomolecular and targeted drug delivery studies

    Viitala, T., Liang, H., Gupta, M., Zwinger, T., Yliperttula, M. & Bunker, A. 15 Jul 2012 In : Journal of Colloid and Interface Science. 378, 1, p. 251-259 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  7. An impedance QCM study on the partitioning of bioactive compounds in supported phospholipid bilayers

    Kannisto, K., Murtomäki, L. & Viitala, T. 15 Apr 2011 In : Colloids and Surfaces B: Biointerfaces. 86, 2, p. 298-304 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  8. Silymarin loaded liposomes for hepatic targeting: In vitro evaluation and HepG2 drug uptake

    Elmowafy, M., Viitala, T., Ibrahim, H. M., Abu-Elyazid, S. K., Samy, A., Kassem, A. & Yliperttula, M. 9 Oct 2013 In : European Journal of Pharmaceutical Sciences. 50, 2, p. 161-171 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

View all (83) »

Latest activities

  1. Faculty of Science (Organisational unit)

    Viitala, T. (Board member)
    Jan 2018 → …

    Activity: MembershipMembership or other role in national/international committee, council, board

  2. Management Committee of COST action CA16205 UNGAP (External organisation)

    Garcia Horsman, J. A. (Board member), Mikko Koskinen (Board member), Strachan, C. (Expert), Siven, M. (Expert), Viitala, T. (Expert)
    1 Oct 201730 Sep 2021

    Activity: MembershipMembership or other role in national/international committee, council, board

  3. European Journal of Pharmaceutics and Biopharmaceutics (Journal)

    Viitala, T. (Reviewer)
    28 Aug 2017

    Activity: Publication peer-review and editorial workPeer review of manuscripts

View all (174) »

Education

Fil. toht., kemia

ID: 80994