Yan-Ru Lou


Description of research and teaching

Key research interests

Tissue engineering for drug research

My research focuses on developing functional and predictive cell-based tools for drug research and personalized medicine. We use stem cells- and biomaterials-based tissue engineering approach to produce functional cells and tissues. We have developed flexible, dynamic three-dimensional (3D) culture systems for human pluripotent stem cells (human embryonic stem cells and induced pluripotent stem cells) and human cancer cells. The current specific objective is to generate functional hepatocytes with 3D configuration as drug development tools for drug and chemical testing. We apply advanced cell culture technologies and novel biomaterials, along with molecular biology methods. Our research not only develops new cell-based technologies but also advance fundamental understanding of how matrix and biomaterials affect cell behavior and performance.



Cell-biomaterials interactions, pharmaceutical and medical applications (lecture course 590284, 3 credits)

In vitro drug permeability (Advanced biopharmaceutics practicals 590289)


Curriculum Vitae

Short curriculum vitae


BSc in Pharmacy, School of Pharmacy, West China University of Medical Sciences, Chengdu, China, 1996

PhD in Molecular Endocrinology, Faculty of Medicine, University of Tampere, Finland, 2005

Academic posts

Pharmacist, Institute for Drug Control, Xi'An, China, 1996-1999

Researcher, University of Tampere, Tampere, Finland, 1999-2006

Senior researcher, REGEA Institute for Regenerative Medicine, Tampere, Finland, 2006-2007

Research scientist, A*STAR Institute of Bioengineering and Nanotechnology (IBN), Singapore, 2007-2009

Principal investigator, University of Helsinki, Helsinki, Finland, 2009-


Latest publications

  1. A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals

    Smutný, T., Harjumäki, R., Kanninen, L., Yliperttula, M. L., Pávek, P. & Lou, Y-R. 11 Jun 2018 In : Toxicology in Vitro. 52, p. 94-105 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

  2. Differences in definitive endoderm induction approaches using growth factors and small molecules

    Bogacheva, M. S., Khan, S., Kanninen, L. K., Yliperttula, M., Leung, A. W. & Lou, Y-R. Apr 2018 In : Journal of Cellular Physiology. 233, 4, p. 3578-3589 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

  3. Next generation organoids for biomedical research and applications

    Lou, Y-R. & Leung, A. W. 2018 In : Biotechnology Advances. 36, 1, p. 132-149 18 p.

    Research output: Contribution to journalReview ArticleScientificpeer-review

View all (54) »

Latest activities

  1. keynote speaker

    Lou, Y. (Keynote speaker)
    28 Sep 201729 Sep 2017

    Activity: Talk or presentationInvited talk

  2. Scientific Reports (Journal)

    Lou, Y. (Reviewer)
    Aug 2017

    Activity: Publication peer-review and editorial workPeer review of manuscripts

  3. Scientific Reports (Journal)

    Lou, Y. (Reviewer)
    Jun 2017

    Activity: Publication peer-review and editorial workPeer review of manuscripts

View all (89) »

Latest prizes

  1. Award for outstanding overseas PhD student

    Yan-Ru Lou (Recipient), 2004

    Prize: Prizes and awards

  2. Travel grant

    Yan-Ru Lou (Recipient), 2015

    Prize: Prizes and awards

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Latest projects

  1. CIMO Fellowship / Bogacheva

    Lou, Y. & Bogacheva, M.


    Project: Research project

  2. Stem cell-derived, three-dimensional liver: the missing link in drug discovery

    Lou, Y., Harjumäki, R., Kanninen, L., Smutný, T., Bogacheva, M., Salmi, T., Makhdoom, Y. & Taalas, A. P.



    Project: Research project

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Muu tai tuntematon koulutus, koulutusaste tuntemat

ID: 5735