Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr192 and compromises its cardioprotective activity

Research output: Contribution to journalArticleScientificpeer-review

Ilona Kareinen, Marc Baumann, Su Duy Nguyen, Katariina Maaninka, Andrey Anisimov, Minoru Tozuka, Matti Jauhiainen, Miriam Lee-Rueckert, Petri T. Kovanen

LanguageEnglish
JournalJournal of Lipid Research
Volume59
Issue number6
Pages945-957
Number of pages13
ISSN0022-2275
DOIs
Publication statusPublished - Jun 2018
MoE publication typeA1 Journal article-refereed

    Research areas

  • apolipoproteins, carboxyl-terminal truncation, cardiac ischemia, cells and tissues, endothelial cells, diseases/atherosclerosis, high density lipoproteins, reconstituted high density lipoprotein, mass spectrometry, proteolysis, APOLIPOPROTEIN-A-I, HIGH-DENSITY-LIPOPROTEIN, REVERSE CHOLESTEROL TRANSPORT, AORTIC INTIMAL FLUID, MYOCARDIAL ISCHEMIA/REPERFUSION, VASCULAR-PERMEABILITY, ENDOTHELIAL REPAIR, OXIDATIVE STRESS, CORONARY-ARTERY, HEART-DISEASE
  • 1182 Biochemistry, cell and molecular biology
  • 3121 Internal medicine

External organisations

Kareinen, Ilona
  • Wihuri Research Institute
Su Duy Nguyen
  • Wihuri Research Institute
Maaninka, Katariina
  • Wihuri Research Institute
Anisimov, Andrey
  • Wihuri Research Institute
Tozuka, Minoru
  • Tokyo Medical and Dental University
Jauhiainen, Matti
  • Minerva Foundation Institute for Medical Research
  • THL National institute for health and welfare
Lee-Rueckert, Miriam
  • Wihuri Research Institute
Kovanen, Petri T.
  • Wihuri Research Institute

ID: 108674651