Research outputs

  1. Accepted/In press

    School culture, leadership and relationships matter

    General information

    StateAccepted/In press
    Ministry of Education publication typeB1 Journal article
    OrganisationsDepartment of Education
    ContributorsToom, A. H.
    Publication dateJul 2018
    Peer-reviewedNo

    Publication information

    JournalTeachers and Teaching
    Volume24
    Issue number7
    ISSN (Print)1354-0602
    Ratings
    • Scopus rating (2017): SJR 1.497 SNIP 1.66
    • Scopus rating (2016): SJR 1.249 SNIP 1.421
    • Scopus rating (2015): SJR 1.186 SNIP 1.478
    • Scopus rating (2014): SJR 0.735 SNIP 1.076
    • Scopus rating (2013): SJR 0.866 SNIP 0.732
    • Scopus rating (2012): SJR 1.367 SNIP 1.17
    • Scopus rating (2011): SJR 1.242 SNIP 1.159
    • Scopus rating (2010): SJR 0.835 SNIP 0.912
    • Scopus rating (2009): SJR 1.116 SNIP 1.172
    • Scopus rating (2008): SJR 0.753 SNIP 1.091
    • Scopus rating (2007): SJR 0.831 SNIP 0.981
    • Scopus rating (2006): SJR 0.358 SNIP 1.201
    • Scopus rating (2005): SJR 0.467 SNIP 0.998
    • Scopus rating (2004): SJR 0.28 SNIP 0.832
    • Scopus rating (2003): SJR 0.425 SNIP 0.85
    • Scopus rating (2002): SJR 0.266 SNIP 0.679
    • Scopus rating (2001): SJR 0.196 SNIP 0.49
    • Scopus rating (2000): SJR 0.859 SNIP 1.15
    • Scopus rating (1999): SJR 0.794 SNIP 1.076
    Original languageEnglish

    Research output: Contribution to journalArticleScientific

  2. On the sample complexity of finding good search strategies

    General information

    StatePublished
    Ministry of Education publication typeA4 Article in conference proceedings
    OrganisationsUniversity of Toronto, Department of Computer Science
    ContributorsOrponen, P., Greiner, R.
    Number of pages6
    Pages352-358
    Publication date1990

    Host publication information

    Title of host publicationCOLT '90 : Proceedings of the third annual workshop on Computational learning theory
    Volume1990
    Place of publicationRochester, New York
    PublisherMorgan Kaufmann publishers
    ISBN (Print)1-55860-146-5
    Fields of Science113 Computer and information sciences
    Electronic versions

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  3. Presence, extent and location of pancreatic necrosis are independent of aetiology in acute pancreatitis

    Objective The most common aetiologies of acute pancreatitis (AP) are gallstones, alcohol and idiopathic. The impact of the aetiology of AP on the extent and morphology of pancreatic and extrapancreatic necrosis (EXPN) has not been clearly established. The aim of the present study was to assess the influence of aetiology on the presence and location of pancreatic necrosis in patients with AP.

    Patients and methods We carried out a post-hoc analysis of a previously established multicentre cohort of patients with AP in whom a computed tomography was available for review. Clinical data were obtained from the medical records. All computed tomographies were revised by the same expert radiologist. The impact of aetiology on pancreatic and EXPN was calculated.

    Results In total, 159 patients with necrotizing pancreatitis were identified from a cohort of 285 patients. The most frequent aetiologies were biliary (105 patients, 37%), followed by alcohol (102 patients, 36%) and other aetiologies including idiopathic (78 patients, 27%). No relationship was found between the aetiology and the presence of pancreatic necrosis, EXPN, location of pancreatic necrosis or presence of collections.

    Conclusion We found no association between the aetiology of AP and the presence, extent and anatomical location of pancreatic necrosis. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

    General information

    StatePublished
    Ministry of Education publication typeA1 Journal article-refereed
    OrganisationsDepartment of Surgery, Clinicum, St Antonius Hosp, St. Antonius Hospital Utrecht, Dept Gastroenterol & Hepatol, University of Lund, East Tallinn Cent Hosp, Dept Gastroenterol, Hosp del Mar, Hospital del Mar, Dept Gastroenterol, Univ Halle Wittenberg, Martin Luther University Halle Wittenberg, Univ Clin Halle, Dept Internal Med 4, St Antonius Hosp, St. Antonius Hospital Utrecht, Dept Radiol, St Antonius Hospital, Univ Hosp Emergency Med Pirogov, Dept Surg, Lithuanian University of Health Sciences, Kaunas, Lithuania
    ContributorsVerdonk, R. C., Sternby, H., Dimova, A., Ignatavicius, P., Koiva, P., Penttilä, A. K., Ilzarbe, L., Regner, S., Rosendahl, J., Bollen, T. L.
    Number of pages4
    Pages342-345
    Publication dateMar 2018
    Peer-reviewedYes

    Publication information

    JournalEuropean Journal of Gastroenterology and Hepatology
    Volume30
    Issue number3
    ISSN (Print)0954-691X
    Ratings
    • Scopus rating (2017): SJR 0.986 SNIP 0.72
    • Scopus rating (2016): SJR 0.917 SNIP 0.79
    • Scopus rating (2015): SJR 0.92 SNIP 0.872
    • Scopus rating (2014): SJR 0.954 SNIP 0.984
    • Scopus rating (2013): SJR 1.003 SNIP 0.967
    • Scopus rating (2012): SJR 0.825 SNIP 0.841
    • Scopus rating (2011): SJR 0.78 SNIP 0.817
    • Scopus rating (2010): SJR 0.727 SNIP 0.82
    • Scopus rating (2009): SJR 0.786 SNIP 0.924
    • Scopus rating (2008): SJR 0.856 SNIP 0.971
    • Scopus rating (2007): SJR 0.836 SNIP 0.899
    • Scopus rating (2006): SJR 0.773 SNIP 0.95
    • Scopus rating (2005): SJR 0.747 SNIP 0.915
    • Scopus rating (2004): SJR 0.67 SNIP 0.916
    • Scopus rating (2003): SJR 0.613 SNIP 0.906
    • Scopus rating (2002): SJR 0.43 SNIP 0.68
    • Scopus rating (2001): SJR 0.486 SNIP 0.797
    • Scopus rating (2000): SJR 0.383 SNIP 0.657
    • Scopus rating (1999): SJR 0.417 SNIP 0.844
    Original languageEnglish
    Fields of Scienceacute pancreatitis, alcohol, gallstones, necrosis, ATLANTA CLASSIFICATION, GALLSTONE, MULTICENTER, ALCOHOL, 3121 Internal medicine
    DOIs
    SourceWOS
    Source-ID000436015800018

    Research output: Contribution to journalArticleScientificpeer-review

  4. NEULA: a hybrid neural-symbolic expert system shell

    General information

    StatePublished
    Ministry of Education publication typeB1 Journal article
    OrganisationsDepartment of Computer Science, Helsinki Institute for Information Technology, Complex Systems Computation research group / Petri Myllymäki, The Finnish Center of Excellence in Computational Inference Research (COIN) , Department of Computer Science, UH
    ContributorsFloreen, P. B. J., Myllymäki, P. J., Orponen, P., Tirri, H.
    Number of pages7
    Pages11-18
    Publication date1992
    Peer-reviewedNo

    Publication information

    JournalTietojenkäsittelytiede
    Volume1992
    Issue number3
    ISSN (Print)0788-4818
    Original languageEnglish
    Fields of Science113 Computer and information sciences
    Electronic versions

    Research output: Contribution to journalArticleScientific

  5. Accepted/In press

    Digital learning environment mediating students’ funds of knowledge and knowledge creation

    General information

    StateAccepted/In press
    Ministry of Education publication typeA1 Journal article-refereed
    OrganisationsDepartment of Education
    ContributorsKajamaa, A. M., Kumpulainen, P. K., Rajala, A. J.
    Publication date2018
    Peer-reviewedYes

    Publication information

    JournalStudia paedagogica
    Volume23
    Issue number4
    ISSN (Print)1803-7437
    Original languageEnglish

    Research output: Contribution to journalArticleScientificpeer-review

  6. Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits

    Objective: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits.

    Methods: We estimated single-nucleotide polymorphism (SNP)-based heritability and analyzed genetic correlation between depressive symptoms and T2D and glycemic traits with the linkage disequilibrium score regression by combining summary statistics of previously conducted-meta-analyses for depressive symptoms by CHARGE consortium (N = 51,258), T2D by DIAGRAM consortium (N = 34,840 patients and 114,981 controls), fasting glucose, fasting insulin, and homeostatic model assessment of beta-cell function and insulin resistance by MAGIC consortium (N = 58,074). Finally, we investigated pleiotropic loci using a bivariate genome-wide association study approach with summary statistics from genome-wide association study meta-analyses and reported loci with genome-wide significant bivariate association p value (p <5 x 10(-8)). Biological annotation and function of significant pleiotropic SNPs were assessed in several databases.

    Results: The SNP-based heritability ranged from 0.04 to 0.10 in each individual trait. In the linkage disequilibrium score regression analyses, depressive symptoms showed no significant genetic correlation with T2D or glycemic traits (p > 0.37). However, we identified pleiotropic genetic variations for depressive symptoms and T2D (in the IGF2BP2, CDKAL1, CDKN2B-AS, and PLEKHA1 genes), and fasting glucose (in the MADD, CDKN2B-AS, PEX16, and MTNR1B genes).

    Conclusions: We found no significant overall genetic correlations between depressive symptoms, T2D, or glycemic traits suggesting major differences in underlying biology of these traits. However, several potential pleiotropic loci were identified between depressive symptoms, T2D, and fasting glucose, suggesting that previously established phenotypic associations may be partly explained by genetic variation in these specific loci.

    General information

    StatePublished
    Ministry of Education publication typeA1 Journal article-refereed
    OrganisationsMedicum, Department of Psychology and Logopedics, University of Helsinki, Faculty of Medicine, Department of General Practice and Primary Health Care, Clinicum, Centre of Excellence in Complex Disease Genetics, Institute for Molecular Medicine Finland, Helsinki Collegium for Advanced Studies, University of Groningen, Harvard Med Sch, Harvard University, Dept Med, Univ Mississippi, University of Mississippi, University of Mississippi Medical Center, Med Ctr, Dept Med, Univ Pittsburgh, Pennsylvania Commonwealth System of Higher Education (PCSHE), University of Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, NHLBI, National Heart Lung & Blood Institute (NHLBI), National Institutes of Health (NIH) - USA, Framingham Heart Study, Erasmus University Medical Center Rotterdam, NIA, National Institutes of Health (NIH) - USA, NIH National Institute on Aging (NIA), Longitudinal Study Sect, Translat Gerontol Branch, NIH, VU University Amsterdam, Wake Forest Univ, Wake Forest University, Dept Internal Med, Div Geriatr, Univ Exeter, University of Exeter, Sch Med, Rush Univ, Rush University, Med Ctr, Rush Alzheimers Dis Ctr, Florida State University, NIA, National Institutes of Health (NIH) - USA, NIH National Institute on Aging (NIA), Hlth Dispar Res Sect, Lab Epidemiol & Populat Sci, NIH, German Ctr Diabet Res DZD, Northwestern Univ, Feinberg School of Medicine, Northwestern University, Feinberg Sch Med, Dept Prevent Med, Univ Med Greifswald, Greifswald Medical School, Inst Community Med, German Ctr Neurodegenerat Dis DZNE, German Center for Neurodegenerative Diseases (DZNE), Helmholtz Association, University of Michigan, Folkhälsan Research Center, University of Lund
    ContributorsHaljas, K., Amare, A. T., Alizadeh, B. Z., Hsu, Y., Mosley, T., Newman, A., Murabito, J., Tiemeier, H., Tanaka, T., van Duijn, C., Ding, J., Llewellyn, D. J., Bennett, D. A., Terracciano, A., Launer, L., Ladwig, K., Cornelis, M. C., Teumer, A., Grabe, H., Kardia, S. L. R., Ware, E. B., Smith, J. A., Snieder, H., Eriksson, J. G., Groop, L., Räikkönen, K., Lahti, J.
    Number of pages10
    Pages242-251
    Publication dateApr 2018
    Peer-reviewedYes

    Publication information

    JournalPsychosomatic Medicine
    Volume80
    Issue number3
    ISSN (Print)0033-3174
    Ratings
    • Scopus rating (2017): SJR 2.001 SNIP 1.354
    • Scopus rating (2016): SJR 1.944 SNIP 1.39
    • Scopus rating (2015): SJR 1.858 SNIP 1.293
    • Scopus rating (2014): SJR 2.106 SNIP 1.485
    • Scopus rating (2013): SJR 2.165 SNIP 1.589
    • Scopus rating (2012): SJR 2.166 SNIP 1.533
    • Scopus rating (2011): SJR 2.14 SNIP 1.795
    • Scopus rating (2010): SJR 2.107 SNIP 1.648
    • Scopus rating (2009): SJR 2.147 SNIP 1.593
    • Scopus rating (2008): SJR 2.034 SNIP 1.551
    • Scopus rating (2007): SJR 1.958 SNIP 1.674
    • Scopus rating (2006): SJR 2.301 SNIP 1.88
    • Scopus rating (2005): SJR 1.79 SNIP 1.909
    • Scopus rating (2004): SJR 1.719 SNIP 1.83
    • Scopus rating (2003): SJR 1.646 SNIP 1.801
    • Scopus rating (2002): SJR 1.774 SNIP 1.597
    • Scopus rating (2001): SJR 1.742 SNIP 1.799
    • Scopus rating (2000): SJR 1.234 SNIP 1.793
    • Scopus rating (1999): SJR 1.403 SNIP 1.853
    Original languageEnglish
    Fields of Sciencedepression, meta-analysis, Type 2 diabetes, pleiotropy, GWAS, FATIGUE SYNDROME/MYALGIC ENCEPHALOMYELITIS, SINGLE-NUCLEOTIDE POLYMORPHISMS, GENE-EXPRESSION SUBTYPES, MAJOR DEPRESSION, RISK-FACTOR, SUSCEPTIBILITY LOCI, INSULIN-RESISTANCE, BIPOLAR DISORDER, FASTING GLUCOSE, METAANALYSIS, 3124 Neurology and psychiatry, 3121 Internal medicine, 515 Psychology
    DOIs
    SourceWOS
    Source-ID000436027400402

    Research output: Contribution to journalArticleScientificpeer-review

  7. Trends in diagnosis-specific work disability before and after ischaemic heart disease: a nationwide population-based cohort study in Sweden

    Objectives We examined trends of diagnosis-specific work disability before and after ischaemic heart disease (IHD).

    Design Participants were followed 4 years before and 4 years after an IHD event for diagnosis-specific work disability (sickness absence and disability pension).

    Setting and participants A Swedish population-based cohort study using register data on all individuals aged 25-60 years, living in Sweden, and who suffered their first IHD event in 2006-2008 (n=23 971) was conducted.

    Results Before the event, the most common diagnoses of work disability were musculoskeletal disorders (21 annual days for men and 44 for women) and mental disorders (19 men and 31 for women). After multivariable adjustments, we observed a fivefold increase (from 12 to 60 days) in work disability due to diseases of the circulatory system in the first postevent year compared with the last pre-event year among men. Among women, the corresponding increase was fourfold (from 14 to 62 days). By the second postevent year, the number of work disability days decreased significantly compared with the first postevent year among both sexes (to 19 days among men and 23 days among women). Among women, mean days of work disability due to diseases of the circulatory system remained at a higher level than among men during the postevent years. Work disability risk after versus before an IHD event was slightly higher among men (rate ratio (RR) 2.49; 95% CI 2.36 to 2.62) than among women (RR 2.29, 95% CI 2.12 to 2.49). When pre-event long-term work disability was excluded, diseases of the circulatory system were the most prevalent diagnosis for work disability after an IHD event among both men and women.

    Conclusions An IHD event was strongly associated with an increase in work disability due to diseases of the circulatory system, especially among men and particularly in the first postevent year.

    General information

    StatePublished
    Ministry of Education publication typeA1 Journal article-refereed
    OrganisationsClinicum, Faculty of Medicine, Finnish Institute of Occupational Health (TTL), Karolinska Institutet, Uppsala University
    ContributorsErvasti, J., Virtanen, M., Lallukka, T., Friberg, E., Mittendorfer-Rutz, E., Lundström, E., Alexanderson, K.
    Number of pages9
    Publication dateApr 2018
    Peer-reviewedYes

    Publication information

    JournalBMJ Open
    Volume8
    Issue number4
    Article number in E-publication (not DOI)019749
    ISSN (Print)2044-6055
    Ratings
    • Scopus rating (2017): SJR 1.372 SNIP 1.177
    • Scopus rating (2016): SJR 1.474 SNIP 1.239
    • Scopus rating (2015): SJR 1.528 SNIP 1.304
    • Scopus rating (2014): SJR 1.404 SNIP 1.164
    • Scopus rating (2013): SJR 1.137 SNIP 1.163
    • Scopus rating (2012): SJR 0.495 SNIP 0.996
    Original languageEnglish
    Fields of SciencePERCUTANEOUS CORONARY INTERVENTION, CARDIOVASCULAR-DISEASE, RHEUMATOID-ARTHRITIS, RISK-FACTORS, MYOCARDIAL-INFARCTION, PRODUCTIVITY LOSS, SICKNESS ABSENCE, ARTERY-DISEASE, PREMATURE EXIT, PREDICTORS, 3121 Internal medicine
    Electronic versions
    DOIs
    SourceWOS
    Source-ID000435176700091

    Research output: Contribution to journalArticleScientificpeer-review

  8. Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene

    The aim of the study was to explore the parent-of-origin effects (POEs) on a range of human nuclear magnetic resonance metabolites. Materials & methods: We search for POEs in 14,815 unrelated individuals from Estonian and Finnish cohorts using POE method for the genotype data imputed with 1000 G reference panel and 82 nuclear magnetic resonance metabolites. Results: Meta-analysis revealed the evidence of POE for the variant rs1412727 in PTPRD gene for the metabolite: triglycerides in medium very low-density lipoprotein. No POEs were detected for genetic variants that were previously known to have main effect on circulating metabolites. Conclusion: We demonstrated possibility to detect POEs for human metabolites, but the POEs are weak, and therefore it is hard to detect those using currently available sample sizes.

    General information

    StatePublished
    Ministry of Education publication typeA1 Journal article-refereed
    OrganisationsQuantitative Genetics, Institute for Molecular Medicine Finland, University of Helsinki, Imperial College London, University of Tartu, National Institute for Health and Welfare (THL)
    ContributorsPervjakova, N., Kukushkina, V., Haller, T., Kasela, S., Joensuu, A., Kristiansson, K., Annilo, T., Perola, M., Salomaa, V., Jousilahti, P., Metspalu, A., Magi, R.
    Number of pages8
    Pages439-446
    Publication dateMay 2018
    Peer-reviewedYes

    Publication information

    JournalBiomarkers in Medicine
    Volume12
    Issue number5
    ISSN (Print)1752-0363
    Ratings
    • Scopus rating (2017): SJR 0.75 SNIP 0.533
    • Scopus rating (2016): SJR 0.783 SNIP 0.542
    • Scopus rating (2015): SJR 0.859 SNIP 0.636
    • Scopus rating (2014): SJR 1.007 SNIP 0.634
    • Scopus rating (2013): SJR 1.048 SNIP 0.756
    • Scopus rating (2012): SJR 0.826 SNIP 0.636
    • Scopus rating (2011): SJR 0.588 SNIP 0.495
    • Scopus rating (2010): SJR 0.326 SNIP 0.23
    • Scopus rating (2009): SJR 0.187 SNIP 0.2
    Original languageEnglish
    Fields of ScienceEGCUT, FINRISK, NMR metabolites, parent-of-origin effects, PTPRD, VLDL, CARDIOVASCULAR RISK-FACTORS, RICH LIPOPROTEINS, MISSING HERITABILITY, ASSOCIATION, DISEASE, LOCI, ARCHITECTURE, PERSPECTIVE, HOMEOSTASIS, FINLAND, 3111 Biomedicine
    Electronic versions
    DOIs
    SourceWOS
    Source-ID000436264900004

    Research output: Contribution to journalArticleScientificpeer-review

  9. Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants

    Introduction The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis. The aim of the present study is to assess if the CoMiSS can be used as a potential diagnostic tool in infants with suspected CMPA.

    Methods and analysis Exclusively formula-fed infants aged 0-6 months presenting with symptoms suggestive of CMPA will be included in this prospective, multicentre trial which will be conducted in 10 centres in China. All infants will commence a 2-week trial of an amino acid-based formula (AAF) while eliminating all cow milk protein from their diets. After the AAF treatment period, infants will undergo an open OFC in hospital with standard cow's milk formula, followed by an open home challenge for another 2 weeks. Clinical symptoms will be documented on standardised symptom scorecards. The CoMiSS will be determined at study entry (CoMiSS 1, before the start of the AAF), after 2 weeks (CoMiSS 2, before the OFC) and after a further period of 2 weeks or when symptoms suggestive of CMPA reappear (CoMiSS 3). Weight and length will be measured at each visit. The difference between CoMiSS 1 and 2 as a predictor of the OFC outcome will also be assessed. The diagnostic accuracy of the baseline CoMiSS will be calculated.

    Ethics and dissemination The study was approved by the Hunan Children's Hospital Medical Ethics Committee, Hunan, China. The findings of this trial will be submitted for publication in a peer-reviewed journal in paediatric nutrition or gastroenterology. Abstracts will be submitted to the relevant national and international conferences.

    General information

    StatePublished
    Ministry of Education publication typeA1 Journal article-refereed
    OrganisationsClinicum, Children's Hospital, University of Helsinki, Cytel Software Corp, Grp Hop Inst Catholique Lille, Universite Catholique de Lille, Hop St Vincent de Paul, Clin Pediat St Antoine, Univ Hosp Geneva, University of Geneva, Paediat Allergy Unit, Odense Univ Hosp, Odense University Hospital, Hans Christian Andersen Childrens Hosp, Dept Paediat, La Fe Univ Hosp, Paediat Gastroenterol & Hepatol Unit, Katholieke Univ Leuven, KU Leuven, University Hospital Leuven, Univ Hosp Leuven, Leuven Ctr Algol & Pain Management, Med Univ Warsaw, Medical University Warsaw, Dept Paediat, Marien Hosp, St. Marien Hospital, Res Inst, Dept Paediat, Nestle Hlth Sci, Univ Sch Med, Zhejiang University, Childrens Hosp Zhejiang, Vrije Univ Brussel
    ContributorsChinese CoMiSS Investigator Team
    Number of pages9
    Publication dateMay 2018
    Peer-reviewedYes

    Publication information

    JournalBMJ Open
    Volume8
    Issue number5
    Article number in E-publication (not DOI)019968
    ISSN (Print)2044-6055
    Ratings
    • Scopus rating (2017): SJR 1.372 SNIP 1.177
    • Scopus rating (2016): SJR 1.474 SNIP 1.239
    • Scopus rating (2015): SJR 1.528 SNIP 1.304
    • Scopus rating (2014): SJR 1.404 SNIP 1.164
    • Scopus rating (2013): SJR 1.137 SNIP 1.163
    • Scopus rating (2012): SJR 0.495 SNIP 0.996
    Original languageEnglish
    Fields of SciencePROTEIN ALLERGY, DIAGNOSIS, 3121 Internal medicine
    Electronic versions
    DOIs
    SourceWOS
    Source-ID000435567200067

    Research output: Contribution to journalArticleScientificpeer-review

  10. Which anthropometric measures best indicate type 2 diabetes among Russian, Somali and Kurdish origin migrants in Finland? A cross-sectional study

    Objectives To compare the performance of body mass index (BMI), waist-to-height ratio (WHtR), waist circumference (WC) and waist-to-hip ratio (WHR) in detecting type 2 diabetes among Russian, Somali and Kurdish (born in Iraq/Iran) origin migrants and Finns.

    Design and participants Cross-sectional study comparing health examination survey data of Russian, Somali and Kurdish origin migrants (n=917) aged 30-64 years who took part in the Migrant Health and Wellbeing Survey with the general Finnish population in the Health 2011 Survey (n=887). Participants were randomly selected from the National Population Register.

    Setting Six cities in Finland, where a substantial majority of migrants live.

    Outcome measures Anthropometric measures included objectively measured BMI, WHtR, WC and WHR. Type 2 diabetes was defined based on self-report, laboratory measures of glycated haemoglobin and register data. Test performance was assessed using receiver operating characteristics curves, using area under the curve (AUC) as a measure of accuracy.

    Results Among Finns, test performance was highest for WC (AUC=0.81, 95% Cl 0.74 to 0.87) and WHtR (AUC=0.81, 95% CI 0.75 to 0.87). Test performance was similar for BMI (AUC=0.80, 95% CI 0.67 to 0.92), WC (AUC=0.79, 95% CI 0.67 to 0.91) and WHtR (AUC=0.70, 95% CI 0.66 to 0.93) among Russians. WC and WHtR had highest test performance also among Somali (AUC=0.74, 95% CI 0.64 to 0.84 for WC and AUC=0.75, 95% CI 0.65 to 0.85 for WHtR) and Kurds (AUC=0.71, 95% CI 0.61 to 0.81 for WC and AUC=0.70, 95% CI 0.59 to 0.80 for WHtR). Among migrants, WHR had the poorest test performance.

    Conclusion WC and WHtR performed overall the best across all study groups, however, accuracy of detection was lower particularly among Somali and Kurds. Currently used diabetes risk assessment tools assume a strong association between anthropometrics and diabetes. These tools need to be validated among non-Western populations.

    General information

    StatePublished
    Ministry of Education publication typeA1 Journal article-refereed
    OrganisationsClinicum, Public Health, Department of Public Health, University of Helsinki, National Institute for Health and Welfare (THL), University of Eastern Finland, Joint Municipal Author North Karelia Social & Hlt
    ContributorsSkogberg, N., Laatikainen, T., Lundqvist, A., Lilja, E., Härkänen, T., Koponen, P.
    Number of pages9
    Publication dateMay 2018
    Peer-reviewedYes

    Publication information

    JournalBMJ Open
    Volume8
    Issue number5
    Article number in E-publication (not DOI)019166
    ISSN (Print)2044-6055
    Ratings
    • Scopus rating (2017): SJR 1.372 SNIP 1.177
    • Scopus rating (2016): SJR 1.474 SNIP 1.239
    • Scopus rating (2015): SJR 1.528 SNIP 1.304
    • Scopus rating (2014): SJR 1.404 SNIP 1.164
    • Scopus rating (2013): SJR 1.137 SNIP 1.163
    • Scopus rating (2012): SJR 0.495 SNIP 0.996
    Original languageEnglish
    Fields of ScienceSUB-SAHARAN AFRICANS, MIDDLE-EAST, INSULIN-RESISTANCE, METABOLIC SYNDROME, NATIVE SWEDES, ETHNIC-DIFFERENCES, RISK-FACTORS, IMMIGRANTS, PREVALENCE, DISEASE, 3121 Internal medicine, 3142 Public health care science, environmental and occupational health
    Electronic versions
    DOIs
    SourceWOS
    Source-ID000435567200034

    Research output: Contribution to journalArticleScientificpeer-review

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