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Hussein M. Abkallo, Axel Martinelli, Megumi Inoue, Abhinay Ramaprasad, Phonepadith Xangsayarath, Jesse Gitaka, Jianxia Tang, Kazuhide Yahata, Augustin Zoungrana, Hayato Mitaka, Arita Acharjee, Partha P. Datta, Paul Hunt, Richard Carter, Osamu Kaneko, Ville Mustonen, Christopher J. R. Illingworth, Arnab Pain, Richard Culleton
Rapid identification of genes controlling virulence and immunity in malaria parasites
www.plospathogens.org
www.plospathogens.org
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5.074 0 Td
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-33.4259 -1.2983 Td
(ling)Tj
1.7461 0 Td
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(phenotypic)Tj
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4.5638 0 Td
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/F14 1 Tf
3.3278 0 Td
[()4( )4()10()6(\r)4()12()12()12()]TJ
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[()3(\r)4()15( )12()12()]TJ
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1.7347 0 Td
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(1)Tj
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4.9039 0 Td
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1.9105 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
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3.9174 0 Td
(this)Tj
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3.5263 0 Td
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1.7121 0 Td
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2.8573 0 Td
(of)Tj
/F14 1 Tf
1.0148 0 Td
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[()3(\r)4()15( )12()12()]TJ
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(that)Tj
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3.5716 0 Td
(complex)Tj
3.617 0 Td
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4.8019 0 Td
(concomi-)Tj
-32.5415 -1.3039 Td
(tantly)Tj
2.5001 0 Td
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1.9956 0 Td
(high)Tj
2.0069 0 Td
(genomic)Tj
3.6737 0 Td
(resolution)Tj
4.2802 0 Td
(within)Tj
2.812 0 Td
(a)Tj
0.652 0 Td
(short)Tj
2.2903 0 Td
(space)Tj
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(of)Tj
1.0147 0 Td
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ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 311.1874 cm
BT
/F2 1 Tf
1 TL
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0 0 Td
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/F0 1 Tf
0 -1.4976 Td
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7.4079 0 Td
(of)Tj
1.0488 0 Td
(strain)Tj
2.6363 0 Td
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(immunity)Tj
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1.8662 0 Td
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(rate)Tj
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5.0551 0 Td
(between)Tj
3.9496 0 Td
(CU)Tj
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(and)Tj
1.8614 0 Td
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ET
Q
q
1 j
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BT
/F9 1 Tf
1 TL
-0.004 Tc
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1.7801 0 Td
(difference)Tj
4.2066 0 Td
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1.0375 0 Td
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3.0727 0 Td
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1.7518 0 Td
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(the)Tj
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1.7121 0 Td
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/F14 1 Tf
3.651 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()15()3(\r)]TJ
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-35.8183 -1.2982 Td
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(nine)Tj
2.007 0 Td
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(17X1.1pp)Tj
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4.337 0 Td
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3.6056 0 Td
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4.2066 0 Td
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1.7348 0 Td
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1.9956 0 Td
(17X1.1pp,)Tj
4.2633 0 Td
(CU)Tj
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(or)Tj
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(mock)Tj
-32.6435 -1.3039 Td
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(challenge)Tj
3.9572 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
0.6577 0 Td
(mixture)Tj
3.3902 0 Td
(of)Tj
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(clones)Tj
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0.83 0.64 0.02 0 k
(S1)Tj
1.5136 0 Td
(Fig)Tj
0 g
(\).)Tj
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1.7802 0 Td
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(tions)Tj
2.1996 0 Td
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1.0148 0 Td
(the)Tj
1.4684 0 Td
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1.7121 0 Td
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2.126 0 Td
(measured)Tj
4.1045 0 Td
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1.2756 0 Td
(day)Tj
1.6384 0 Td
(four)Tj
1.9162 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(infection)Tj
3.7928 0 Td
(by)Tj
1.1792 0 Td
(real)Tj
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(quantitative)Tj
-31.3623 -1.2983 Td
(PCR)Tj
2.0636 0 Td
(\(Q-RT-PCR\))Tj
5.4254 0 Td
(targeting)Tj
3.7871 0 Td
(the)Tj
1.474 0 Td
(polymorphic)Tj
/F14 1 Tf
5.3745 0 Td
[()10()]TJ
/F9 1 Tf
2.2733 0 Td
(locus)Tj
2.2847 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.075 0 Td
(A)Tj
0.9014 0 Td
(strong,)Tj
2.999 0 Td
(statistically)Tj
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(significant)Tj
-33.2671 -1.3039 Td
(SSI)Tj
1.508 0 Td
(was)Tj
1.7007 0 Td
(induced)Tj
3.464 0 Td
(by)Tj
1.1848 0 Td
(both)Tj
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(parasite)Tj
3.3278 0 Td
(strains)Tj
2.863 0 Td
(in)Tj
1.0318 0 Td
(CBA)Tj
2.1487 0 Td
(mice)Tj
2.1543 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(2B)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
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11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
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1 TL
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5.7591 0 Td
(of)Tj
1.0488 0 Td
(high-confidence)Tj
7.1859 0 Td
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ET
Q
q
1 j
1 J
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BT
/F9 1 Tf
1 TL
-0.004 Tc
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(kinds)Tj
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(this)Tj
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(and)Tj
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