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Guo Luo, Ling Lin, Louis Jacob, Mélodie Bonvalet, Aditya Ambati, Giuseppe Plazzi, Fabio Pizza, Ryan Leib, Christopher M. Adams, Markku Partinen, Emmanuel Jean-Marie Mignot
Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases
www.plosone.org
www.plosone.org
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(MF59C.1)Tj
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(80)Tj
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1 j
1 J
0 w
7.4999 0 0 6.6659 261.5811 633.8267 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
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(1)Tj
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Q
q
1 j
1 J
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(24)Tj
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7.4999 0 0 6.6659 566.5322 633.8267 cm
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1 TL
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(1)Tj
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Q
q
1 j
1 J
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1 TL
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(GSK)Tj
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2.8856 0 Td
(identical)Tj
3.6567 0 Td
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1.0261 0 Td
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 319.8614 607.8614 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
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(1)Tj
ET
Q
q
1 j
1 J
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BT
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1 TL
-0.004 Tc
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 428.6551 594.822 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
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(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 438.2929 590.4 cm
BT
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1 TL
-0.004 Tc
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(vaccination)Tj
4.8302 0 Td
(in)Tj
1.0318 0 Td
(20092010)Tj
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(and)Tj
-34.2365 -1.2982 Td
(DQ0602)Tj
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(positive.)Tj
3.5376 0 Td
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3.2372 0 Td
(narcolepsy)Tj
4.507 0 Td
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 365.5559 568.8566 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
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(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 375.1937 564.3779 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
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(even)Tj
2.0692 0 Td
(in)Tj
1.0375 0 Td
(DQ0602)Tj
3.6056 0 Td
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3.9798 0 Td
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5.8733 0 Td
(and)Tj
1.7291 0 Td
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(isola-)Tj
-34.6333 -1.3039 Td
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(protocol\),)Tj
4.1612 0 Td
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(immune)Tj
3.6283 0 Td
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3.0047 0 Td
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(targeted)Tj
3.4582 0 Td
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0.8561 0 Td
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0.8504 0 Td
(notable)Tj
3.1804 0 Td
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-34.5936 -1.2983 Td
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2.33 0 Td
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4.8245 0 Td
(campaign)Tj
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3.8948 0 Td
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-33.6809 -1.2982 Td
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1.7178 0 Td
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4.8301 0 Td
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1.4683 0 Td
(unfolding)Tj
4.1499 0 Td
(pandemic)Tj
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-34.4406 -1.2983 Td
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3.084 0 Td
(one)Tj
1.7008 0 Td
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(the)Tj
1.4683 0 Td
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2.2054 0 Td
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3.1407 0 Td
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3.4923 0 Td
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1.9275 0 Td
(be)Tj
1.1508 0 Td
(that)Tj
1.7802 0 Td
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 453.8267 477.8645 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 463.4645 473.3858 cm
BT
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1 TL
-0.004 Tc
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(had)Tj
1.7121 0 Td
(strong)Tj
2.7722 0 Td
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(most)Tj
-34.588 -1.2982 Td
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4.1159 0 Td
(countries)Tj
3.9515 0 Td
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(26)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(31)Tj
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3.5433 0 Td
(and)Tj
1.7291 0 Td
(that)Tj
1.7801 0 Td
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ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 392.0314 464.8251 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 399.5149 460.4031 cm
BT
/F8 1 Tf
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-0.004 Tc
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(,)Tj
0.4422 0 Td
(a)Tj
0.6576 0 Td
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2.88 0 Td
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2.9423 0 Td
(vaccine)Tj
3.1975 0 Td
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1.7064 0 Td
(less)Tj
1.6158 0 Td
(or)Tj
1.0941 0 Td
(no)Tj
-34.486 -1.2982 Td
(effects)Tj
2.727 0 Td
(in)Tj
1.0318 0 Td
(Quebec)Tj
3.2711 0 Td
(and)Tj
1.7348 0 Td
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4.3993 0 Td
(that)Tj
1.7802 0 Td
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4.5636 0 Td
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1.0375 0 Td
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3.1918 0 Td
(composition)Tj
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1.4513 0 Td
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-33.9191 -1.3039 Td
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1.0148 0 Td
(suggested)Tj
4.0706 0 Td
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1.1848 0 Td
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3.2032 0 Td
[()8()]TJ
0.907 0 Td
[()11()]TJ
/F8 1 Tf
(.)Tj
1.1679 0 Td
([)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(].)Tj
0.005 Tc
-10.352 -1.2983 Td
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4.3029 0 Td
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1.2926 0 Td
(these)Tj
2.3017 0 Td
(observations,)Tj
5.6013 0 Td
(several)Tj
2.9933 0 Td
(authors)Tj
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3.7814 0 Td
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1.4967 0 Td
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3.0501 0 Td
(pH1N1)Tj
3.2371 0 Td
(monovalent)Tj
5.0967 0 Td
(vaccines,)Tj
3.8608 0 Td
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2.0352 0 Td
(primary)Tj
3.5149 0 Td
(focus)Tj
2.3754 0 Td
(on)Tj
1.2926 0 Td
(Pandemrix)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 489.6 412.8377 cm
BT
/F13 1 Tf
1 TL
0.0067 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 499.3511 408.4157 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(and)Tj
1.7574 0 Td
(Arepanrix)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 558.5952 412.8377 cm
BT
/F13 1 Tf
1 TL
0.0067 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 566.1354 408.4157 cm
BT
/F8 1 Tf
1 TL
0.005 Tc
0 0 Td
(,)Tj
-36.612 -1.3039 Td
(the)Tj
1.4967 0 Td
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1.7348 0 Td
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3.6284 0 Td
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2.0352 0 Td
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4.7112 0 Td
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2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(].)Tj
2.1203 0 Td
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1.8142 0 Td
(creation)Tj
3.5602 0 Td
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1.0375 0 Td
(flu)Tj
1.3096 0 Td
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-33.7604 -1.2982 Td
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0.8674 0 Td
(a)Tj
0.6576 0 Td
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2.024 0 Td
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3.2484 0 Td
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1.8142 0 Td
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3.5546 0 Td
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3.5943 0 Td
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4.5468 0 Td
(engineered)Tj
4.7338 0 Td
(flu)Tj
1.3096 0 Td
(strains)Tj
2.9253 0 Td
(in)Tj
/F14 1 Tf
1.0488 0 Td
[()-4()11()4()12( )-4(\n)]TJ
2.7666 0 Td
[(\r)2()11()4()12( )-4(\n)]TJ
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-33.0914 -1.2983 Td
(\(chicken\))Tj
4.0875 0 Td
(eggs,)Tj
2.2054 0 Td
(and)Tj
1.7574 0 Td
(purifying)Tj
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3.2598 0 Td
(particles)Tj
3.6454 0 Td
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1.7574 0 Td
(antigens)Tj
3.634 0 Td
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1.4173 0 Td
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3.2542 0 Td
(preparation,)Tj
5.244 0 Td
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-34.2706 -1.2983 Td
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3.5149 0 Td
(focus)Tj
2.3755 0 Td
(on)Tj
1.2925 0 Td
(Hemagglutinin)Tj
6.4176 0 Td
(\(HA\))Tj
2.3868 0 Td
(and)Tj
1.7575 0 Td
(Neuraminidase)Tj
6.4743 0 Td
(\(NA\),)Tj
2.5908 0 Td
(two)Tj
1.7405 0 Td
(surface)Tj
3.1124 0 Td
(proteins)Tj
3.583 0 Td
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-35.2458 -1.3039 Td
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1.474 0 Td
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3.5433 0 Td
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3.7247 0 Td
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1.0545 0 Td
(lymphocyte)Tj
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1.3096 0 Td
([)Tj
0.83 0.64 0.02 0 k
(34)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(].)Tj
3.6169 0 Td
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-34.7865 -1.2982 Td
(pH1N1-like)Tj
5.0626 0 Td
(vaccine)Tj
3.2599 0 Td
(strains)Tj
2.9253 0 Td
(X-179A)Tj
3.3845 0 Td
(and)Tj
1.7575 0 Td
(X-181)Tj
2.6986 0 Td
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2.16 0 Td
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3.1804 0 Td
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1.0545 0 Td
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2.092 0 Td
(York)Tj
2.262 0 Td
(Medical)Tj
3.4979 0 Td
(College)Tj
-33.3352 -1.2983 Td
(\(NYMC\))Tj
3.8778 0 Td
(for)Tj
1.4116 0 Td
(the)Tj
1.4967 0 Td
(20092010)Tj
4.6261 0 Td
(swine)Tj
2.5455 0 Td
(flu)Tj
1.3096 0 Td
(campaign,)Tj
4.4334 0 Td
(using)Tj
2.4377 0 Td
(an)Tj
1.2189 0 Td
(old)Tj
1.5307 0 Td
(H1N1-1918-like)Tj
6.8372 0 Td
(strain,)Tj
2.7892 0 Td
(A/)Tj
-34.5144 -1.3039 Td
(Puerto)Tj
2.9593 0 Td
(Rico/8/1934)Tj
5.1761 0 Td
(\(PR8\),)Tj
2.8346 0 Td
(as)Tj
1.0318 0 Td
(a)Tj
0.6633 0 Td
(backbone,)Tj
4.3767 0 Td
(and)Tj
1.7518 0 Td
(reassorted)Tj
4.3937 0 Td
(with)Tj
2.0295 0 Td
(A/California/07/2009)Tj
8.9518 0 Td
([)Tj
0.83 0.64 0.02 0 k
(38)Tj
0 g
(].)Tj
-34.1686 -1.2983 Td
(In)Tj
1.1282 0 Td
(both)Tj
2.0919 0 Td
(X-179A)Tj
3.3902 0 Td
(and)Tj
1.7575 0 Td
(X-181)Tj
2.6929 0 Td
(strains,)Tj
3.1578 0 Td
(HA,)Tj
1.9275 0 Td
(NA)Tj
1.6555 0 Td
(and)Tj
1.7574 0 Td
(polymerase)Tj
4.8699 0 Td
(\(basic\))Tj
2.9537 0 Td
(protein)Tj
3.2145 0 Td
(1)Tj
0.7086 0 Td
(\(PB1\))Tj
2.5569 0 Td
(were)Tj
-33.8625 -1.2983 Td
(derived)Tj
3.2768 0 Td
(from)Tj
2.2451 0 Td
(A)Tj
0.9127 0 Td
(/California/07/2009,)Tj
8.4925 0 Td
(while)Tj
2.4152 0 Td
(other)Tj
2.3924 0 Td
(proteins)Tj
3.5829 0 Td
(were)Tj
2.16 0 Td
(PR8-derived)Tj
5.3235 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(40)Tj
0 g
(].)Tj
1.7744 0 Td
(NYMC)Tj
-34.3443 -1.3039 Td
(X-181,)Tj
2.931 0 Td
(characterized)Tj
5.6749 0 Td
(by)Tj
1.1962 0 Td
(a)Tj
0.6633 0 Td
(mutation)Tj
3.9912 0 Td
(of)Tj
1.0375 0 Td
(HA)Tj
1.6894 0 Td
(146N)Tj
2.4151 0 Td
(to)Tj
1.0432 0 Td
(146D)Tj
2.4207 0 Td
(and)Tj
1.7575 0 Td
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1 TL
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1 TL
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1 TL
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1 TL
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7.4999 0 0 6.6659 417.0897 620.844 cm
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1 j
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7.4999 0 0 6.6659 505.1905 594.822 cm
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 244.1763 568.8566 cm
BT
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1 TL
-0.0053 Tc
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(1)Tj
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Q
q
1 j
1 J
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7.4999 0 0 6.6659 340.7811 555.8173 cm
BT
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1 TL
-0.0053 Tc
0 0 Td
(1)Tj
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Q
q
1 j
1 J
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10 0 0 10 350.4188 551.3952 cm
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1 TL
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(vaccination.)Tj
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 505.9842 536.7118 cm
BT
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1 TL
-0.0053 Tc
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(111-121)Tj
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Q
q
1 j
1 J
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1 TL
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(\(YDKEEIRRIWR\))Tj
7.5911 0 Td
(with)Tj
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(NP)Tj
1.5137 0 Td
(116I)Tj
1.9899 0 Td
(\(underlined\))Tj
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0 w
7.4999 0 0 6.6659 457.0015 510.6897 cm
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1 TL
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(34-45)Tj
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Q
q
1 j
1 J
0 w
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1 j
1 J
0 w
7.4999 0 0 6.6659 384.3212 497.707 cm
BT
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1 TL
-0.0053 Tc
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(111-121)Tj
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Q
q
1 j
1 J
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7.4999 0 0 6.6659 311.811 490.7905 cm
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1 j
1 J
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1 j
1 J
0 w
7.4999 0 0 6.6659 380.6362 464.8251 cm
BT
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1 TL
-0.0053 Tc
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(1)Tj
ET
Q
q
1 j
1 J
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7.4999 0 0 6.6659 340.3842 451.7858 cm
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1 TL
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(1)Tj
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7.4999 0 0 6.6659 342.3685 386.8157 cm
BT
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1 TL
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1 j
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7.4999 0 0 6.6659 395.1496 386.8157 cm
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7.4999 0 0 6.6659 454.6204 386.8157 cm
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1 TL
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(1)Tj
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1 j
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3.0443 0 Td
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q
1 j
1 J
0 w
7.4999 0 0 6.6659 244.1763 543.5149 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 251.6031 539.0362 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(,)Tj
0.4478 0 Td
(Arepanrix)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 296.9007 543.5149 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 306.5952 539.0362 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
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(and)Tj
1.7291 0 Td
(Focetria)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 356.4283 543.5149 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 366.0661 539.0362 cm
BT
/F8 1 Tf
1 TL
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1.7347 0 Td
[()]TJ
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(first)Tj
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[()]TJ
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1.2642 0 Td
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7.4834 0 Td
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(chromatography)Tj
6.8769 0 Td
(\(HPLC\))Tj
3.4299 0 Td
(grade)Tj
2.4434 0 Td
(acetone)Tj
3.2768 0 Td
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0.9525 0 Td
(-80C,)Tj
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0.9524 0 Td
(4C,)Tj
1.9786 0 Td
(12000)Tj
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[()]TJ
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3.1691 0 Td
[(\r)]TJ
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0.6293 0 Td
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1.3889 0 Td
(15)Tj
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4.9833 0 Td
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3.7473 0 Td
(and)Tj
1.7348 0 Td
(protein)Tj
3.152 0 Td
(pellets)Tj
2.7326 0 Td
(dried.)Tj
2.5625 0 Td
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2.7779 0 Td
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(digested)Tj
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(\(1:25)Tj
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1.1848 0 Td
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1.4684 0 Td
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(acid.)Tj
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3.9798 0 Td
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3.5546 0 Td
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2.6077 0 Td
(spin)Tj
1.9162 0 Td
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(\(Cat#)Tj
2.4321 0 Td
(NC9270379,)Tj
5.1703 0 Td
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2.041 0 Td
(group)Tj
2.6078 0 Td
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-34.8998 -1.3039 Td
(and)Tj
1.7291 0 Td
(dried)Tj
2.3358 0 Td
(by)Tj
1.1848 0 Td
(speed-vacuum.)Tj
6.2362 0 Td
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3.4979 0 Td
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2.1202 0 Td
(then)Tj
2.0183 0 Td
(reconstituted)Tj
5.4935 0 Td
(in)Tj
1.0375 0 Td
(20)Tj
/F15 1 Tf
1.1735 0 Td
[()]TJ
/F8 1 Tf
(L)Tj
1.2643 0 Td
(2%)Tj
1.4513 0 Td
(acetonitrile,)Tj
4.9549 0 Td
(0.1%)Tj
-34.4973 -1.2983 Td
(formic)Tj
2.897 0 Td
(acid,)Tj
2.0976 0 Td
(and)Tj
1.7291 0 Td
(97.9%)Tj
2.6306 0 Td
(water,)Tj
2.6532 0 Td
(and)Tj
1.7291 0 Td
(3)Tj
/F15 1 Tf
0.6973 0 Td
[()]TJ
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(L)Tj
1.2643 0 Td
(of)Tj
1.0147 0 Td
(sample)Tj
3.0217 0 Td
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1.7008 0 Td
(injected)Tj
3.3902 0 Td
(onto)Tj
2.0806 0 Td
(a)Tj
0.652 0 Td
(self-packed)Tj
4.7111 0 Td
(15)Tj
1.1735 0 Td
(cm)Tj
1.4627 0 Td
(C18)Tj
-34.9055 -1.2983 Td
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3.0501 0 Td
(phase)Tj
2.4831 0 Td
(column)Tj
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(\(Easy-nLC)Tj
4.4843 0 Td
(II,)Tj
1.1226 0 Td
(ThermoFisher)Tj
5.9582 0 Td
(Scientific\))Tj
4.2406 0 Td
(where)Tj
2.6533 0 Td
(a)Tj
0.6519 0 Td
(linear)Tj
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(gradient)Tj
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(340%)Tj
2.9197 0 Td
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2.9933 0 Td
(phase)Tj
2.4832 0 Td
(B)Tj
0.7993 0 Td
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1.973 0 Td
(2)Tj
0.6973 0 Td
(hours)Tj
2.517 0 Td
(to)Tj
1.0205 0 Td
(elute)Tj
2.143 0 Td
(peptides)Tj
3.5546 0 Td
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1.8425 0 Td
(the)Tj
1.4683 0 Td
(mass)Tj
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(spectrometer.)Tj
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3.1351 0 Td
(ionization)Tj
4.2803 0 Td
(was)Tj
1.6951 0 Td
(done)Tj
2.228 0 Td
(using)Tj
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(a)Tj
0.6576 0 Td
(spray)Tj
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(voltage)Tj
3.0501 0 Td
(of)Tj
1.0148 0 Td
(1.7)Tj
1.3946 0 Td
(kilovoltage)Tj
4.5638 0 Td
(\(kV\).)Tj
2.3187 0 Td
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1.7801 0 Td
(mass)Tj
2.1997 0 Td
(spectrome-)Tj
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1.7008 0 Td
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(LTQ)Tj
2.1146 0 Td
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3.736 0 Td
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2.4491 0 Td
(or)Tj
1.0999 0 Td
(Orbitrap)Tj
3.7359 0 Td
(Fusion)Tj
2.9594 0 Td
(\(ThermoFisher)Tj
6.2985 0 Td
(Scientific\))Tj
4.2406 0 Td
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(acquire)Tj
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(a)Tj
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(data)Tj
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(dependent)Tj
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(acquisition)Tj
4.6318 0 Td
(\(DDA\))Tj
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(mode,)Tj
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1.0374 0 Td
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(12)Tj
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4.0932 0 Td
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(the)Tj
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(trap.)Tj
2.0636 0 Td
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1.7802 0 Td
(target)Tj
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(ion)Tj
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(values)Tj
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(\(AGC)Tj
2.6249 0 Td
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-36.1641 -1.2983 Td
(tings\))Tj
2.5001 0 Td
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2.1203 0 Td
(7.5)Tj
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[()]TJ
/F8 1 Tf
(10)Tj
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Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 273.2031 361.474 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(5)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F8 1 Tf
1 TL
-0.004 Tc
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(and)Tj
1.7291 0 Td
(2.5)Tj
/F15 1 Tf
[()]TJ
/F8 1 Tf
(10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 323.2062 361.474 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
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(4)Tj
ET
Q
q
1 j
1 J
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BT
/F8 1 Tf
1 TL
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(the)Tj
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(trap,)Tj
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q
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1 J
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11.9999 0 0 11.9999 200.0125 328.0251 cm
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q
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1 J
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1 J
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7.4999 0 0 6.6659 227.7921 302.4566 cm
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Q
q
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1 J
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(and)Tj
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(Preview)Tj
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Q
q
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1 J
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7.4999 0 0 6.6659 286.5826 302.4566 cm
BT
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1 TL
-0.0053 Tc
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(1)Tj
ET
Q
q
1 j
1 J
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10 0 0 10 296.2771 298.0346 cm
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1 TL
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(\(version1.4,)Tj
4.8926 0 Td
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(MS)Tj
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(spectra)Tj
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Q
q
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1 J
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7.4999 0 0 6.6659 308.6362 289.474 cm
BT
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1 TL
-0.0053 Tc
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(1)Tj
ET
Q
q
1 j
1 J
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/F8 1 Tf
1 TL
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(analysis)Tj
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2.0013 0 Td
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1 j
1 J
0 w
7.4999 0 0 6.6659 426.8409 289.474 cm
BT
/F13 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(1)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 436.5354 285.0519 cm
BT
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1 TL
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(\(A/California/07/)Tj
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(2009,)Tj
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(NYMC)Tj
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1.026 0 Td
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(X-181\),)Tj
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(NYMC)Tj
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(X-179,)Tj
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(NYMC)Tj
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(X-179A,)Tj
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(A/Puerto)Tj
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(Rico/8/1934\).)Tj
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[()11()]TJ
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([)Tj
0.83 0.64 0.02 0 k
(43)Tj
0 g
(])Tj
1.8538 0 Td
(study\))Tj
2.7269 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
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(1)Tj
0 g
(\))Tj
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(and)Tj
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(AIE5269,)Tj
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(which)Tj
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(2014\))Tj
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(Table)Tj
2.778 0 Td
(1)Tj
0 g
(\).)Tj
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(X-179A)Tj
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(sequences)Tj
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(X-181)Tj
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(2012\))Tj
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(Table)Tj
2.7836 0 Td
(1)Tj
0 g
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(which)Tj
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4.1952 0 Td
(HA)Tj
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(146D)Tj
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(and)Tj
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(NP)Tj
-34.7014 -1.2982 Td
(116M)Tj
2.5398 0 Td
([)Tj
0.83 0.64 0.02 0 k
(33)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(43)Tj
0 g
(].)Tj
1.7348 0 Td
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(statistical)Tj
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(Cochran-Mantel-Haenszel)Tj
10.8566 0 Td
(chi)Tj
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